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Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage Ⅱ/Ⅲ colorectal cancer:Cancer progression and prognosis

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World Journal of Gastroenterology 2020年第43期26卷 6853-6866页

作者： Xue-Ling Kang Li-Rui He Yao-Li Chen Shu-Bin Wang Department of Oncology Peking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036Guangdong ProvinceChina Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Pathology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Oncology Peking University Shenzhen HospitalShenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchChina Cancer Institute of Shenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036Guangdong ProvinceChina

BACKGROUND Cancer stem cells(CSCs)are a subpopulation of cancer cells with the potential of self-renewal and *** play critical roles in tumorigenesis,recurrence,metastasis,radiation tolerance and *** To assess the expression patterns and clinical potential of doublecortin-like kinase 1(DCLK1)and leucine-rich repeat-containing G-protein-coupled receptor 5(Lgr5),as prognostic CSC markers of colorectal cancer(CRC).METHODS The expression of DCLK1 and Lgr5 in CRC tissue sections from 92 patients was determined by *** case was evaluated using a combined scoring method based on signal intensity staining(scored 0-3)and the proportion of positively stained cancer cells(scored 0-3).The final staining score was calculated as the intensity score multiplied by the proportion *** expression of DCLK1 and Lgr5 was defined as a score of 0-3;high expression of DCLK1 and Lgr5 was defined as a score of≥*** were categorized as either high or low expression,and the correlation between the expression of DCLK1 or Lgr5 and clinicopathological factors was *** DCLK1 and Lgr5 expression levels were significantly positively *** patients with high DCLK1,Lgr5 and DCLK1/Lgr5 expressions had poorer progression-free survival and overall ***,high expression of DCLK1 was an independent prognostic factor for recurrence and overall survival in patients with CRC by multivariate analysis(P=0.026 and P=0.049,respectively).CONCLUSION DCLK1 may be a potential CSC marker for the recurrence and survival of CRC patients.

关键词： Colorectal cancer Cancer stem cells doublecortin-like kinase 1 Leucine-rich repeat-containing G-protein-coupled receptor 5 Cancer prognosis Cancer progression

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