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Large-Scale Proteomics Data Reveal Integrated Prognosis-Related protein Signatures and Role of SMAD4 and rad50 in Prognosis and Immune Infiltrations of Prostate Cancer Microenvironment

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Phenomics 2022年第6期2卷 404-418页

作者： Aihetaimujiang Anwaier Shu-Xuan Zhu Xi Tian Wen-Hao Xu Yue Wang Maierdan Palihati Wei-Yue Wang Guo-Hai Shi Yuan-Yuan Qu Hai-Liang Zhang Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer CenterNo.270 Dong’an RoadShanghai 200032People’s Republic of China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 20032People’s Republic of China Department of Endocrine and Breast Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016People’s Republic of China

As prostate cancer(PCa)is one of the most commonly diagnosed cancer worldwide,identifying potential prognostic bio-markers is *** this study,the survival information,gene expression,and protein expression data of 344 PCa cases were collected from the Cancer Proteome Atlas(TCPA)and the Cancer Genome Atlas(TCGA)to investigate the potential prognostic *** integrated prognosis-related proteins(IPRPs)model was constructed based on the risk score of each patients using machine-learning *** model suggested that Elevated rad50 expression(p=0.016)and down-regulated SMAD4 expression(p=0.017)were significantly correlated with unfavorable outcomes for PCa ***(IHC)staining and western blot(WB)analysis revealed significant differential expression of SMAD4 and rad50 protein between tumor and normal tissues in validation *** to the overall IHC score,patients with low SMAD4(prad50 expression(p=0.0001)were significantly correlated with poor ***,expression of SMAD4 showed significantly negative correlation with most immune checkpoint molecules,and the low SMAD4 expression group exhibited significantly high levels of LAG3(pproteins were mainly involved in antigen processing and presentation,stem cell differentiation,and type I interferon pathways.

关键词： Prostate cancer Proteomics Prognosis SMAD family member 4 double-strand break repair protein rad50

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