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Red meat intake and the risk of endometrial cancer:Metaanalysis of observational studies

World Journal of Meta-Analysis 2015年第2期3卷 125-132页

作者： Woong Ju Na Na Keum Dong Hoon Lee Yun Hwan Kim Seung Cheol Kim Eric L Ding Eunyoung Cho Department of Obstetrics and Gynecology Medical Research InstituteCollege of MedicineEwha Womans University Department of Epidemiology Harvard School of Public Health Department of Nutritron Harvard School of Public Health Department of Dermatology the Warren Alpert Medical School of Brown University

AIM:To evaluate whether red meat intake is related to the risk of endometrial cancer(EC) using ***:We searched Pub Med,EMBASE,and the Cochrane Library up to June 2013,using common keywords related to red meat and ***-control studies and cohort studies comparing the risk of endometrial cancer among categories by the amount of intake were *** case-control studies and five cohort studies met our *** performed a conventional and a dose-response meta-analysis of case-control studies using the Der Simonian-Laird method for *** cohort studies we performed a conventional *** bias was evaluated using Egger's ***:In the meta-analysis of 11 case-control studies including 5419 cases and 12654 controls,higher red meat consumption was associated with an increased risk of EC [summary relative risk(SRR) = 1.43,95%CI:1.15-1.79;I2 = 73.3% comparing extreme intake categories).In a dose-response analysis,for red meat intake of 100 g/d,SRR was 1.84(95%CI:1.64-2.05).In contrast,in the meta-analysis of five prospective studies including a total of 2549 cases among 247746 participants,no significant association between red meat intake and EC risk(SRR = 0.97,95%CI:0.85-1.11;I2 = 4.9% comparing extreme intake categories) was ***:Our meta-analysis found a significantlinear association between red meat intake and EC risk based on case-control studies but this was not confirmed in prospective studies.

关键词： Red meat Endometrial cancer doseresponse Meta-analysis Observational studies

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Systematic review with meta-analysis of the epidemiological evidence relating smoking to type 2 diabetes

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World Journal of Meta-Analysis 2020年第2期8卷 119-152页

作者： Peter N Lee Katharine J Coombs Department of Statistics P.N.Lee Statistics and Computing Ltd.Sutton SM25DASurreyUnited Kingdom

BACKGROUND Evidence relating tobacco smoking to type 2 diabetes has accumulated rapidly in the last few years,rendering earlier reviews considerably *** To review and meta-analyse evidence from prospective studies of the relationship between smoking and the onset of type 2 *** Prospective studies were selected if the population was free of type 2 diabetes at baseline and evidence was available relating smoking to onset of the *** were identified from previous reviews,searches on Medline and Embase and reference *** were extracted on a range of study characteristics and relative risks(RRs)were extracted comparing current,ever or former smokers with never smokers,and current smokers with non-current smokers,as well as by amount currently smoked and duration of ***-and random-effects estimates summarized RRs for each index of smoking overall and by various subdivisions of the data:Sex;continent;publication year;method of diagnosis;nature of the baseline population(inclusion/exclusion of pre-diabetes);number of adjustment factors;cohort size;number of type 2 diabetes cases;age;length of follow-up;definition of smoking;and whether or not various factors were adjusted *** of heterogeneity and publication bias were also *** The literature searches identified 157 relevant publications providing results from 145 ***-three studies were conducted in Asia and 53 in Europe,with 32 in North America,and seven ***-four were in males,10 in females and the rest in both *** diagnosed type 2 diabetes from selfreport by the individuals,79 on medical records,and 51 on *** varied widely in size of the cohort,number of cases,length of follow-up,and ***,random-effects estimates of the RR were 1.33[95%confidence interval(CI):1.28-1.38]for current vs never smoking,1.28(95%CI:1.24-1.32)for current vs non-smoking,1.13(95%CI:1.11-1.16)for former vs never smoking,and 1.25(95%

关键词： Smoking Type 2 diabetes Prospective studies Meta-analyses doseresponse Review

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