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Population density modulates insect progenitive plasticity through the regulation of dopamine biosynthesis

Insect Science 2022年第6期29卷 1773-1789页

作者： Kai Liu Longyu Yuan Lei Yue Weiwen Chen Kui Kang Jun Lv Wenqing Zhang Rui Pang State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Microbial Safety and Health State Key Laboratory of Applied Microbiology Southern ChinaInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhouChina Innovative Institute for Plant Health College of Agriculture and BiologyZhongkai Universityof Agriculture and EngineeringGuangzhouChina

Insect fecundity is a quantitative phenotype strongly affected by genotypes and the ***,interactions between genotypes and environmental factors in modulating insect fecundity remain largely *** study investigated the im-pact of population density on the fecundity of Nilaparvata lugens(brown planthopper;BPH)carrying homozygous high-(HFG)or low-(LFG)fecundity homozygous *** low population densities,the fecundity and population growth rate of both genotypes showed similar increasing trends across generations,while the trends between HFG and LFG under high population densities were *** a combination of temporal analysis and weighted gene co-expression network analyses on RNA-seq data of HFG and LFG under low and high population densities in the lst,3rd,and 5th gener-ations,we identified 2 gene modules that were associated with these density-dependent progenitive *** pathways related to the neural system were simultaneously enriched by the 2 gene ***,Nlpale,which encodes a tyrosine hydroxy-lase,was identified as a key *** RNA interference of this gene and manipulation of its downstream product dopamine significantly affected the basic and density-dependent progenitive phenotypes of *** findings indicated that dopamine biosynthesis is the key regulatory factor that determines fecundity in response to density changes in dif-ferent BPH ***,this study provides insights into the interaction of a typical environmental factor and insect genotype during the process of population regulation.

关键词： dopamine biosynthesis fecundity genotype Nilaparvata lugens popula-tiondensity

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Regulatory mechanisms of dopamine metabolism in a marine Meyerozyma guilliermondii GXDK6 under NaCl stress as revealed by integrative multi-omics analysis

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Synthetic and Systems Biotechnology 2024年第1期9卷 115-126页

作者： Huijie Sun Huashan Bai Yonghong Hu Sheng He Ruihang Wei Duotao Meng Qiong Jiang Hongping Pan Peihong Shen Qian Ou Chengjian Jiang State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Science and TechnologyGuangxi UniversityNanning530004China Guangxi Key Laboratory for Green Processing of Sugar Resources College of Biological and Chemical EngineeringGuangxi University of Science and TechnologyLiuzhou545006China Guangxi Key Laboratory of Birth Defects Research and Prevention Guangxi Key Laboratory of Reproductive Health and Birth Defect PreventionGuangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning530033China College of Food Science and Light Industry Nanjing Tech UniversityNo.30South Puzhu RoadNanjing211816China

dopamine can be used to treat depression,myocardial infarction,and other ***,few reports are available on the de novo microbial synthesis of dopamine from low-cost *** this study,integrated omics technology was used to explore the dopamine metabolism of a novel marine multi-stress-tolerant aromatic yeast Meyerozyma guilliermondii ***6 was found to have the ability to biosynthesize dopamine when using glucose as the substrate.14 key genes for the biosynthesis of dopamine were identified by whole genome-wide *** and proteomic data showed that the expression levels of gene AAT2 encoding aspartate aminotransferase(regulating dopamine anabolism)were upregulated,while gene AO-I encoding copper amine oxidase(involved in dopamine catabolism)were downregulated under 10%NaCl stress compared with non-NaCl stress,thereby contributing to biosynthesis of ***,the amount of dopamine under 10%NaCl stress was 2.51-fold higher than that of zero NaCl,which was consistent with the multi-omics ***-time fluorescence quantitative PCR(RT-qPCR)and high-performance liquid chromatography(HPLC)results confirmed the metabolic model of ***,by overexpressing AAT2,AST enzyme activity was increased by 24.89%,the expression of genes related to dopamine metabolism was enhanced,and dopamine production was increased by 56.36%in recombinant *** conclusion,Meyerozyma guilliermondii GXDK6 could utilize low-cost carbon source to synthesize dopamine,and NaCl stress promoted the biosynthesis of dopamine.

关键词： dopamine biosynthesis Multi-omics analysis NaCl stress Meyerozyma guilliermondii

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