检索结果-南通市图书馆

diwu yanggan Modulates the Wnt/β-catenin Pathway and Inhibits Liver Carcinogenesis Signaling in 2-AAF/PH Model Rats

Current Medical Science 2019年第6期39卷 913-919页

作者： Bin-bin ZHAO Zhi-hua YE Xiang GAO Han-min LI Basic Medicine College Hubei University of Traditional Chinese MedicineWuhan 430065China Hepatology Institute Hubei Provincial Hospital of Traditional Chinese Medicine&Affiliated Hospital to Hubei University of Traditional Chinese MedicineHubei Institute of Traditional Chinese MedicineWuhan 430061China

The activation of the Wnt/β-catenin signaling pathway in oval cells after liver injury is implicated in *** yanggan capsule is a Chinese herbal medicine that has been used for treating liver *** present study aimed to examine the mechanism by which diwu yanggan inhibits liver carcinogenesis,and the involvement of the Wnt/β-catenin signaling *** yanggan capsule was administered to 2-acetaminofluorene/partial hepatectomy(2-AAF/PH)rats,a murine model of liver *** biomarkers of oval cells and key proteins in the Wnt/p-catenin signaling pathway were assessed on postoperative day 8,10,14,17,19 and *** results showed that treatment with diwu yanggan was associated with reduced expression of oval cell and stem cell biomarkers in the 2-AAF/PH *** expression pattern of key proteins in the Wnt/β-catenin pathway was altered in diwu yanggan-treated animals,indicating that the diwu yanggan treatment accelerated the activation of the Wnt/β-catenin pathway in the initial stage and contributed to its deactivation in the later *** findings indicated that hepatocyte proliferation was suppressed in diwu yanggan-treated animals,compared with untreated 2-AAF/PH *** together,diwu yanggan capsule may reduce the risk of hepatocarcinogenesis by modulating the Wnt/β-catenin signaling pathway.

关键词： diwu yanggan 2-acetam inofluorene/partial hepatectomy(2-AAF/PH) liver regeneration hepatocarcinogenesis Wnt/β-catenin pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：