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Hyperbranched copolymers made from A_2, B_2 and BB'_2 type monomers (iv)——Copolymerization of divinyl sulfone with 4,4'-trimethylenedipiperidine and N-ethylethylenediamine

引用

Science China Chemistry 2001年第2期44卷 207-215页

作者：高超汤为颜德岳王招军竺品芳陶萍 College of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai China Instrumental Analytical Center Shanghai Jiao Tong University Shanghai China

The new approach for synthesis of hyperbranched polymers from commercially available A2 and BB'2 type monomers was extended to synthesize hyperbranched copolymers. In this work, hyperbranched copoly(sulfone-amine) was prepared by copolymerization of divinyl sulfone (A2) with 4,4'-trimethylenedipiperidine (B2) and N-ethylethylenediamine (BB'2). During the reaction,secondary-amino groups of B2 and BB'2 monomers react rapidly with vinyl groups of A2 monomers within 35 s, generating a type of intermediate containing one vinyl group and two reactive hydrogen atoms. Now the intermediates can be regarded as a new BB2 type monomer, whichfurther polymerizes to form hyperbranched copoly(sulfone-amine). The polymerization mechanism was investigated with FTIR and LC-MSD. The degree of branching (DB) of hyperbranched copolymers increased with decreasing the ratio of 4, 4'-trimethylenedipiperidine to N-ethylethylenediamine, so DB can be controlled. When the initial mole ratio of B2 to BB2 was equal to or higher than four, r≥4, resulted copolymers were semi-crystalline, while copolymers with r<3 were amorphous.

关键词： hyperbranched copoly(sulfone-amine), divinyl sulfone, 4,4′-trimethylenedipiperidine, N-ethylethylenediamine, synthesis.

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Study on Chemical Cross-linking Modification of Hyaluronan and the Biocompatibility of its Derivatives

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第4期15卷 139-150页

作者： HU Guo-ying LIU Xin GU Han-qing The Second Hospital of Tianjin Medical University 300211 TianjinChina The Second Hospital of Tianjin Medical University300211 TianjinChina The Second Hospital of Tianjin Medical University300211 TianjinChina

Objective: Prepare cross-linked HA gels with higher mechanical stability, lower degradation velocity and desirable biocompatibility,so as to extend the usage of ***:*** molecular weight of HA (Mr_ HA ) by viscosimetry;*** cross-linked HA gels by DVS, GTA, DEC;*** the cross-linking and degradation procedure;*** the biocompatibility of the best HA gels. Results:The mechanical stability and durability to degradation of HA-DVS gels are superior to those of other gels, and when HA:DVS = 40:1(g/g), at 35℃ and in 0.2 M NaOH solution, the HA-DVS gel shows the best mechanical stability, and its cytotoxicity reaches class I, hemolysis ratio is lower than 5%. Conclusion:Our HA-DVS gel can be used to prepare biologic scaffolds.

关键词： Hyaluronic acid (Hyaluronan) Cross-linking divinyl sulfone Diepoxy compound Glutaraldehyde Biocompatibility In vitro degradation

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