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Changes in muscular strength and electromyogram in rats with muscular disuse atrophy following electrical stimulation

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Neural Regeneration Research 2006年第9期1卷 809-812页

作者： Xiaoyu Lü1, Xuanming Hao2 1Department of Rehabilitation and Physiotherapy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China 2College of Sports Science, South China Normal University, Guangzhou 510631, Guangdong Province, China Department of Rehabilitation and Physiotherapy Guangzhou General Hospital Guangzhou Military Area Command Guangzhou 510010 Guangdong Province China College of Sports Science South China Normal University Guangzhou 510631 Guangdong Province China

BACKGROUND: atrophy of skeletal muscle is found under the condition of muscular disuse or in the process of fixation. It is affected by fixation, and electromyogram (EMG) discharge and muscular strength levels will be significantly decreased with accelerating tendency. Electrical stimulation (ES) therapy can release the velocity of muscular disuse atrophy effectively, so it is an effective method for preventing and treating muscular disuse atrophy and accelerating rehabilitation velocity following removal of fixation. OBJECTIVE: To observe the effect of ES therapy at different time points following the fixation of rat models of muscular disuse atrophy on muscular strength and EMG of quadriceps femoris. DESIGN: A randomized and controlled animal experiment. SETTING: Department of Rehabilitation and Physiotherapy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA; College of Sports Science, South China Normal University. MATERIALS: Male SD rats, of clean grade, aged 4 months old, weighing (230±10) g, were provided by the Animal Experimental Center of Sun Yat-sen University. EMG measurement and analysis system (NEC Company, Japan) and four-channel recorder (NEC Company, Japan) were used in this experiment. METHODS: This experiment was carried out in the Laboratory of Human Sports Science, South China Normal University between September 2003 and March 2004. Totally 125 successful SD rat models of muscular disuse atrophy were randomly divided into 5 groups with 25 rats in each by a lot: normal control group, in which, the rats were untouched; ES 24 hours, 1, 2 and 3 weeks groups: the knees of rats in these four groups were fixed. Rats in four groups underwent ES therapy at 24 hours, 1, 2 and 3 weeks after fixation. T90-Ⅱ computer ES muscular strength training instrument was used in ES therapy every other day. The instrument was set as square wave, 5 mA current intensity and 10 minutes a day. Muscular strength of quadriceps femoris and data of E

关键词： electrical stimulation disuse atrophy velocity of strength training animal experiment skeletal muscle used in strength of SD rat

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Apoptosis in skeletal muscle and its relevance to atrophy

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World Journal of Gastroenterology 2006年第46期12卷 7463-7466页

作者： Esther E Dupont-Versteegden University of Arkansas for Medical Sciences Departments of Geriatrics and Physiology and Biophysics 4301 West Markham #807 Little Rock AR 72205 and University of Kentucky Department of Rehabilitation Sciences Division of Physical Therapy 900 S Limestone Lexington KY 40536-0200 United States

Apoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal system. The role of apoptosis in post mitotic tissues, such as skeletal muscle, is less well defined. Apoptosis during muscle atrophy occurs in both myonuclei and other muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as -independent pathways have been implicated and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required for different causes of skeletal muscle loss.

关键词： Skeletal muscle Apoptosis disuse atrophy Aging

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EFFECT OF ANGELICA SINENSIS ON AFFERENT DISCHARGE OF SINGLE MUSCLE SPINDLE IN TO ADS

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Journal of Pharmaceutical Analysis 2004年第2期16卷 178-180页

作者：高云芳樊小力 Department of Physiology Medical School of Xi'an Jiaotong Universi ty Xi'an 710061 ChinaCollege of Life SciencesNorthwest UniversityXian710069China College of Life Sciences Northwest UniversityXian710069China

Objective In drugs for i nvigorating blood circulation, to find a herb that can stimulate afferent discha rge of muscle spindle. Methods A single muscle spindle was isolated from sartorial mus cle of toad. Using air-gap technique, afferent discharge of the muscle spindle was recorded. Effects of Angelica Sinensis, Salvia Miltiorrhiza, and Safflower o n afferent discharge of the muscle spindle were observed. Results Angelica Sinensis could distinctly increase afferent di scharge frequency of the muscle spindle, and this increase was dose-dependent. But Salvia Miltiorrhiza and Safflower had no this excitatory effect. Conclusion It is known that Angelica Sinensis can invigorate bl ood circulation, and we have found its excitatory effect on muscle spindle which makes it possible to serve people with muscle atrophy if more evidences from cl inical experiments are available.

关键词： Angelica Sinensis muscle spindle air-gap techni que disuse atrophy

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