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Targeting chaperone-mediated autophagy for Parkinson's disease.therapy

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Neural Regeneration Research 2023年第8期18卷 1723-1724页

作者： Yi-Ting Wang Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao Special Administrative RegionChina

Parkinson's disease.(PD) is the second most prevalent neu rodegenerative *** projections for the global incidence of PD indicate that the number of people with PD might approach 12 million by 2040(Adrissi and Fleisher... 详细信息

关键词： therapy degenerative disease.

Enhanced late blight resistance of transgenic potato expressing glucose oxidase under the control of pathogen-inducible promoter

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Chinese Science Bulletin 2000年第21期45卷 1982-1986,2018页

作者： Wei Zhen Xi Chen Haobo Liang Yuanlei Hu Yin Gao Zhongping Lin Beijing Univ Natl Lab Prot Engn & Plant Genet Engn Beijing 100871 Peoples R China

To engineer crop disease.resistance by utilizing natural defense mechanism that was expressed in the incompatible host-pathogen interactions is expected to result in a durable and broad-spectrum resistance. In order to prove this viewpoint, we amplified the coding region of the glucose oxidase (GO) gene from Aspergillus nigervia PCR and fused it to the pathogen-inducible promoter, Prp1-1. The chimeric gene was cloned into a plant expression vector and conjugated into Agrobacterium. Twenty-three transgenic potato plants were obtained by Agrobacterium-mediated transformation. The integration of GO gene was confirmed by Southern hybridization and the GO gene expression was identified with Kl-starch color reaction. Phytophthora infestans inoculation revealed that the expression of the chimeric transgene was induced by pathogen infection. Most of the transgenic plants exhibited various degrees of enhanced disease.resistance. Four of them had lesion sizes reduced to less than half of the non-transgenic

关键词： glucose oxidase (GO) pathogen-inducible promoter transgenic potato late blight disease.

Construction of chimeric inducible promoters by elicitors of rice fungal blast pathogen and their expression in transgenic rice

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Chinese Science Bulletin 2000年第3期45卷 242-246页

作者： LU Huafei MING Xiaotian QU Lijia LIU Meihua LI Jing GU Hongya CHEN Zhangliang State Key Laboratory of Protein Engineering and Plant Genetic Engineering Peking UniversityBeijing 100871China Demontfort University The GatewaysLeicester LEI 9BHUK

The promoter fragments of wheat GstA1 and potato Gst1 have been amplified by PCR, cloned and fused respectively to the minimal promoter sequence of rice actin gene (Act1)) and its 5’ untranslated leader sequence together with GUS. The constructs with 2 chimeric promoters (WGA and PGA) have been transferred into rice in order to analyze their inducibility patterns in transgenic rice plants. The results show that: WGA and PGA are both inducible by elicitors of Pyricularia oryzae in transgenic rice cells; the intron I of rice Act1 gene is important for the heterogenic expression of monocot and dicot promoter elements in rice; and the Act1 minimal promoter and its 5’untranslated leader sequence produced low level background expression in rice.

关键词： pathogen-inducible chimeric promoter gene expression and regulation transgenic rice rice fungal blast disease.

A Prepandemic Warning!

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China CDC weekly 2020年第29期2卷 551-552页

作者： Robert G.Webster Department of Infectious disease. St.Jude Children’s Research Hospital

The goal of scientists is to provide knowledge that will benefit *** scientific paper(1)published in the Proceedings of the National Academy of Sciences(online on June 29,2020)has the potential of warning the global community of a future pandemic of *** the current focus on the coronavirus disease.2019(COVID-19)pandemic caused by the COVID-19 virus is fully merited because of its catastrophic impact on public health and global economics,it is important not to forget that an influenza pandemic can be even more debilitating.

关键词： forget demic disease.

Forty and Twenty Years Ago and Now--Virus Elimination Successes and New Challenges

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China CDC weekly 2020年第50期2卷 953-954页

作者： Lance E.Rodewald National Immunization Program China CDC Immunization Services Division US CDC(2000-2012) WHO China Country Office(2012-2017)

Forty years ago,smallpox was declared eradicated by the World Health Organization(WHO).As ***,Director of the Smallpox Eradication Programme at the WHO quoted from the 33^(rd) World Health Assembly(1980)(1),“...the world and all its peoples have won freedom from smallpox...a most devastating disease...since earliest time,leaving death,blindness,and disfigurement in its wake and which only a decade ago was rampant in Africa,Asia and South America.”

关键词： death Director disease.

Essentials of Pathophysiology: Concepts of Altered Health States (Point (Lippincott Williams & Wilkins)) 2nd ed.

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2007年

作者： Carol Porth

来源：畅想之星图书光盘版（南... 评论

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Bread and Health

Journal of Pharmacy and Pharmacology 2017年第11期5卷 821-826页

作者： Kourkouta, L. Koukourikos, K. Iliadis, C. Ouzounakis, p. Monios, A. Tsaloglidou, A. Nursing Department Alexander Technological Educational lnstitute of Thessaloniki Thessaloniki 57400 Greece Nursing Department Technological Educationallnstitute of Thessaloniki Thessaloniki 57400 Greece Private Diagnostic Health Center of Thessaloniki Thessaloniki 54623 Greece General Hospital of Alexandroupoli Alexandroupoli 68100 Greece 7th High School of Athens Athens 11634 Greece Nursing Department Technological Educationallnstitute of Thessaloniki Thessaloniki 574 00 Greece

Introduction： Bread is a food full of flavors and nutrients and continues to be the basis of our daily diet. Aim： The aim of this review was the investigation of bread＇s usefulness in our daily dietary chain and health in general. Material-Method： Extensive review of the recent literature was conducted in electronic databases （Medline, Scopus, and Google Scholar） through the Association of Hellenic Academic Libraries （HEAL-Link） using the appropriate key words： bread, health, disease.as well as a combination of them. Results： Bread is an excellent source of complex carbohydrates that provide the body with the energy needed. Although bread is a basic food of everyday human nutrition, it is implicated in a variety of situations that burden the human body, such as obesity. However, this happens only when it is consumed in very large quantities and when it is part of an unbalanced diet. Conclusions： Bread, when is consumed in balanced quantities can give the body plenty of nutrients essential for its good function.

关键词： Bread health disease.

Failingto Get Its Act Together

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Beijing Review 2020年第13期63卷 18-19页

作者： Sherry Qin 不详

As the novel coronavirus situation in the ***,President Donald Trump's March 16 tweet calling the virus"Chinese virus"inflamed an already rampant xenophobic sentiment in the *** racist tweet put the large Asian community in a dangerous position,and experts warned that racism could hamper the global efforts to curb the spread of the disease.

关键词： Together dangerous disease.

Interaction between fulvic acids of different origins and active oxygen radicals

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Science China(Life Sciences) 1996年第3期39卷 267-275页

作者：王春霞王子健彭安侯京武忻文娟 State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China) Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Using the spin trapping technique, the interaction between fulvic acids (FAs) of different origins and the active oxygen radicals was studied. The active oxygen radicals under study included superoxide anion (O2 · -) produced by xanthine oxidase (XOD) and stimulated polymorphonuclear leukocytes (PMN) of human being and hydroxyl radical ( ·OH) produced from Fenton’s reaction. It has been found that the FAs from both Kaschin-Beck disease.(KBD) region and non-KBD region can accelerate the production of ·OH and scavenge O2 ·- . FA from peat can scavenge both O2·- and ·OH. The results show that the behavior of KBD and non-KBD FAs differs clearly from peat FA. It has been concluded that the superoxidation damage of KBD induced by FA is mainly due to hydroxyl radical reaction initiated in biological system.

关键词： fulvic acids active oxygen radicals spin trapping Kaschin-Beck disease.