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Rare peptide anchors of HLA class I alleles contribute to the COVID-19 Disease severity and T cell memory

Biosafety and Health 2023年第6期5卷 355-362页

作者： Xin Wang Jie Zhang Peipei Guo Yuanyuan Guo Xiaonan Yang Maoshun Liu Danni Zhang Yaxin Guo Jianbo Zhan Kun Cai Jikin Zhou Shaobo Dong Jun Liu Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Laboratory of Biosafety Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Beijing Key Laboratory of Emerging Infectious diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Institute of Infectious diseases Beijing 100015China National Center for Infectious diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China Hubei Provincial Center for disease Control and Prevention Wuhan 430079China Shijiazhuang Fifth Hospital Shijiazhuang 050011China Macheng Center for disease Control and Prevention Huanggang 438300China

Understanding how human leukocyte antigen(HLA)polymorphism affects both the susceptibility and severity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection will help to identify individuals at higher risk to better manage and prioritize vaccination at the clinical level and explain the differences in epidemic trends in different regions at the epidemiological level.This study compared the frequencies of HLA class I alleles(HLA-A,B)in 214 coronavirus disease 2019(COVID-19)patients with different Disease severity and 35 healthy controls and analyzed the correlations between specific HLA alleles and Disease severity and T cell memory.The results showed no significant difference in HLA allele frequencies between COVID-19 patients and healthy controls(P>0.05).The allele HLA-B*13:02 was significantly correlated with the Disease severity of COVID-19 patients(P=0.006).After adjustment for age and Disease severity,the T cell responses of COVID-19 convalescents with the allele HLA-B*40:01 may be lower at six months(P=0.044)and 12 months(P=0.069).Moreover,these results may be due to their rare peptide anchors by analyzing the binding peptide motifs of these HLA alleles.The study may be valuable for investigating the potential association of specific HLA alleles with SARS-CoV-2 infection.

关键词： SARS-CoV-2 COVID-19 HLA Susceptibility Disease severity

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Chinese Medical Journal 2021年第6期134卷 690-698页

作者： Jun-Yu Lin Ling-Yu Zhang Bei Cao Qian-Qian Wei Ru-Wei Ou Yan-Bing Hou Kun-Cheng Liu Xin-Ran Xu Zheng Jiang Xiao-Jing Gu Jiao Liu Hui-Fang Shang Department of Neurology West China HospitalSichuan UniversityChengduSichuan 610041China

Background: Sleep disorders are common but under-researched symptoms in patients with multiple system atrophy (MSA). We investigated the frequency and factors associated with sleep-related symptoms in patients with MSA and the impact of sleep disturbances on Disease severity.Methods: This cross-sectional study involved 165 patients with MSA. Three sleep-related symptoms, namely Parkinson’s disease (PD)-related sleep problems (PD-SP), excessive daytime sleepiness (EDS), and rapid eye movement sleep behavior disorder (RBD), were evaluated using the PD Sleep Scale-2 (PDSS-2), Epworth Sleepiness Scale (ESS), and RBD Screening Questionnaire (RBDSQ), respectively. Disease severity was evaluated using the Unified MSA Rating Scale (UMSARS).Results: The frequency of PD-SP (PDSS-2 score of ≥18), EDS (ESS score of ≥10), and RBD (RBDSQ score of ≥5) in patients with MSA was 18.8%, 27.3%, and 49.7%, respectively. The frequency of coexistence of all three sleep-related symptoms was 7.3%. Compared with the cerebellar subtype of MSA (MSA-C), the parkinsonism subtype of MSA (MSA-P) was associated with a higher frequency of PD-SP and EDS, but not of RBD. Binary logistic regression revealed that the MSA-P subtype, a higher total UMSARS score, and anxiety were associated with PD-SP;that male sex, a higher total UMSARS score, the MSA-P subtype, and fatigue were associated with EDS;and that male sex, a higher total UMSARS score, and autonomic onset were associated with RBD in patients with MSA. Stepwise linear regression showed that the number of sleep-related symptoms (PD-SP, EDS, and RBD), disease duration, depression, fatigue, and total Montreal Cognitive Assessment score were predictors of Disease severity in patients with MSA.Conclusions: Sleep-related disorders were associated with both MSA subtypes and the severity of disease in patients with MSA, indicating that sleep disorders may reflect the distribution and degree of dopaminergic/non-dopaminergic neuron degeneration in MSA.

关键词： Multiple system atrophy Sleep disorders Disease severity Subtype

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Treatment satisfaction with rheumatoid arthritis in patients with different Disease severity and financial burden:A subgroup analysis of a nationwide survey in China

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Chinese Medical Journal 2020年第8期133卷 892-898页

作者： Hong-Bin Li Li-Jun Wu Nan Jiang Ping-Ting Yang Sheng-Yun Liu Xiao-Fei Shi Yong-Fei Fang Yi Zhao Jian Xu Zhen-Yu Jiang Zhen-Biao Wu Xin-Wang Duan Qian Wang Meng-Tao Li Xin-Ping Tian Xiao-Feng Zeng Department of Rheumatology Affiliated Hospital of Inner Mongolia Medical CollegeHohhotInner Mongolia 010050China Department of Rheumatology&Immunology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Rheumatology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Rheumatology and Immunology First Affiliated HospitalChina Medical UniversityShenyangLiaoning 110001China Department of Rheumatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Rheumatology and Immunology The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyangHenan 471003China Department of Rheumatology Southwest HospitalThird Military Medical UniversityChongqing 400038China Department of Rheumatology and Immunology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Rheumatology The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Clinical Immunology and Rheumatology Xijing Hospital Affiliated to Air ForceMedical UniversityXi’anShaanxi 710032China Department of Rheumatology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Background:Despite the recent advances in treatments for rheumatoid arthritis (RA), there are still unmet needs in disease outcomes. This study aimed to analyze the satisfaction with drug therapies for RA according to the levels of Disease severity (patientassessed) and proportions of treatment cost to household income.Methods:This was a subgroup study of a cross-sectional study in patients with RA and their physicians. The patients were subdivided into different subgroups based on their self-assessed severity of RA and on the proportions of treatment cost to household income (50%). The Treatment Satisfaction Questionnaire for Medication version II was used to assess patients’ treatment satisfaction.Results:When considering all medications, effectiveness, convenience, and global satisfaction scores were lower in the severe and moderate RA subgroups than those in the mild and extremely mild RA subgroups (all P 50% subgroup (all P diseasemodifying anti-rheumatic drugs, effectiveness and convenience scores were lower in the severe RA subgroup than those in the extremely mild RA subgroup (both P 50% subgroups ( F = 12.646, P = 0.005). Global satisfaction score was higher in the Disease severity and higher financial burden were associated with lower patient satisfaction.

关键词： Disease severity Rheumatoid arthritis Treatment cost Treatment satisfaction

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Quantification of Tc-99m-ethyl cysteinate dimer brain single photon emission computed tomography images using statistical probabilistic brain atlas in depressive end-stage renal disease patients:Correlation with Disease severity and symptom factors

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Neural Regeneration Research 2012年第27期7卷 2151-2159页

作者： Heeyoung Kim In Joo Kim Seong-Jang Kim Sang Heon Song Kyoungjune Pak Keunyoung Kim Department of Nuclear Medicine Pusan National University HospitalBusanRepublic of Korea Biomedical Research Institute Pusan NationalBusanRepublic of Korea Department of Internal Medicine Pusan National University HospitalBusanRepublic of Korea

This study adapted a statistical probabilistic anatomical map of the brain for single photon emission computed tomography images of depressive end-stage renal disease patients. This research aimed to investigate the relationship between symptom clusters, Disease severity, and cerebral blood flow. Twenty-seven patients （16 males, 11 females） with stages 4 and 5 end-stage renal disease were enrolled, along with 25 healthy controls. All patients underwent depressive mood assessment and brain single photon emission computed tomography. The statistical probabilistic anatomical map images were used to calculate the brain single photon emission computed tomography counts. Asymmetric index was acquired and Pearson correlation analysis was performed to analyze the correlation between symptom factors, severity, and regional cerebral blood flow. The depression factors of the Hamilton Depression Rating Scale showed a negative correlation with cerebral blood flow in the left amygdale. The insomnia factor showed negative correlations with cerebral blood flow in the left amygdala, right superior frontal gyrus, right middle frontal gyrus, and left middle frontal gyrus. The anxiety factor showed a positive correlation with cerebral glucose metabolism in the cerebellar vermis and a negative correlation with cerebral glucose metabolism in the left globus pailidus, right inferior frontal gyrus, both temporal poles, and left parahippocampus. The overall depression severity （total scores of Hamilton Depression Rating Scale） was negatively correlated with the statistical probabilistic anatomical map results in the left amygdala and right inferior frontal gyrus. In conclusion, our results demonstrated that the Disease severity and extent of cerebral blood flow quantified by a probabilistic brain atlas was related to various brain areas in terms of the overall severity and symptom factors in end-stage renal disease patients.

关键词： single photon emission computed tomography end-stage renal disease depression statisticalprobabilistic brain atlas Disease severity cerebral blood flow symptom brain neural regeneration

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Significance of low serum vitamin D for infection risk, Disease severity and mortality in critically ill patients

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Chinese Medical Journal 2013年第14期126卷 2725-2730页

作者： SU Long-xiang JIANG Zhao-xu CAO Li-chao XIAO Kun SONG Jia-ping LI Hua ZHANG Xin YAN Peng FENG Dan LIU Chang-ting LI Xin XIE Li-xin Department of Respiratory Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China Clinical Division of Internal Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Medical StatisticsChinese People'sLiberation Army General Hospital Beijing 100853 China Nanlou Department of Espiratory diseases Chinese People's Liberation Army General Hospital Beijing 100853 China Medical College of Nankai University Tianjin 300071 China Department of Respiratory Medicine Tianjin Chest Hospital Tianjin 300051 China Shenzhen Proteome Engineering Laboratory BGI Shenzhen Shenzhen 518001 China

Background Hospitalized patients often have higher rate of vitamin D deficiency than healthy people. Vitamin D levels below normal are associated with hospital stay, increased incidence of adverse prognosis and increased mortality of a number of diseases. Whether there is a relationship between vitamin D levels and infection or sepsis in the critically ill is still unclear. This study will explore the relationship between vitamin D levels and risk of infection, assessment for Disease severity, and predictor of mortality. Methods To evaluate the value of vitamin D in intensive care unit （ICU） cases to sepsis, severity and prognosis assessment, high performance liquid chromatography and tandem mass spectrometry were used to measure the concentrations of vitamin D in sera of critically ill patients. The serum samples were drawn within the first 24 hours of ICU admission. Results The study included 206 people, 50 healthy controls, 51 ICU control patients and 105 ICU diagnosed with sepsis. Critically ill ICU patients （ICU sepsis and ICU control group） had lower vitamin D concentration than normal people, but septic patients showed no significant reduction of vitamin D concentration when compared with critically ill patients with no positive etiological evidence. For assessment of Disease severity, there were very low negative correlations between APACHE II, SAPS II and SOFA scores and vitamin D level. Additionally, patients of different 25-（OH）D levels showed no difference whether in terms of 28-day survival （χ2=1.78, P=0.776） or 90-day survival （χ2=4.12, P=0.369）. Multivariate Logistic regression demonstrated that APECHE II and SAPS II scores were independent risk factors to deaths caused by sepsis. Conclusion Clinically, serum concentration of vitamin D is not an indicator for diagnosis and assessment in critically ill patients （ClinicalTrial.gov identifier NCT01636232）.

关键词： 25-hydroxy vitamin D infection Disease severity mortality critically ill sepsis

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Predictors of Disease severity in ulcerative colitis patients from Southwestern Ontario

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World Journal of Gastroenterology 2010年第2期16卷 232-236页

作者： Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor Division of Gastroenterology London Health Sciences Centre Victoria Hospital800 Commissioner’s Road EastLondon OntarioN6A 5W9Canada Operational Stress Injury Clinic Parkwood HospitalLondonOntarioN6C 5J1Canada

AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict Disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of Disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,PDisease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators.

关键词： Demographic Disease severity Prognosis Ulcerative colitis

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Characterizing and Estimating Fungal Disease severity of Rice Brown Spot with Hyperspectral Reflectance Data

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Rice science 2008年第3期15卷 232-242页

作者： LIU Zhan-yu HUANG Jing-feng TAO Rong-xiang Institute of Agricultural Remote Sensing ＆ Information System Application Zhejiang University Hangzhou 310029 China Institute of Plant Protection and Microbiology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

Large-scale farming of agriculture crops requires real-time detection of disease for field pest management. Hyperspectral remote sensing data generally have high spectral resolution, which could be very useful for detecting disease stress in green vegetation at the leaf and canopy levels. In this study, hyperspectral reflectances of rice in the laboratory and field were measured to characterize the spectral regions and wavebands, which were the most sensitive to rice brown spot infected by Bipolaris oryzae （Helminthosporium oryzae Breda. de Hann）. Leaf reflectance increased at the ranges of 450 to 500 nm and 630 to 680 nm with the increasing percentage of infected leaf surface, and decreased at the ranges of 520 to 580 nm, 760 to 790 nm, 1550 to 1750 nm, and 2080 to 2350 nm with the increasing percentage of infected leaf surface respectively. The sensitivity analysis and derivative technique were used to select the sensitive wavebands for the detection of rice brown spot infected by B. oryzae. Ratios of rice leaf reflectance were evaluated as indicators of brown spot. R669/R746 （the reflectance at 669 nm divided by the reflectance at 746 nm, the following ratios may be deduced by analogy）, R702/R718, R692/R530, R692/R732, R535/R746, R521/R718, and R569/R718 increased significantly as the incidence of rice brown spot increased regardless of whether it＇s at the leaf or canopy level. R702/R718, R692/R530, R692/R732 were the best three ratios for estimating the Disease severity of rice brown spot at the leaf and canopy levels. This result not only confirms the capability of hyperspectral remote sensing data in characterizing crop disease for precision pest management in the real world, but also testifies that the ratios of crop reflectance is a useful method to estimate crop Disease severity.

关键词： derivative spectrum hyperspectral reflectance ratio of spectral reflectance rice brown spot Disease severity Bipolaris oryzae （ Helminthosporium oryzae） sensitivity analysis remote sensing

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Progressive changes in intestinal bacterial communities are associated with shrimp Disease severity

Progressive changes in intestinal bacterial communities are ...

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全国第九届海洋生物技术与创新药物学术会议

作者： Jinfeng Wu Jinbo Xiong Xin Wang Linglin Qiuqian Kunjie Yang Yunxia Qian Kai Wang Jianlin Zhu Demin Zhang School of Marine Sciences Ningbo University Medical School Ningbo University Faculty of Architectural Civil Engineering and EnvironmentNingbo University

Increasing evidence has revealed a close association between intestinal bacterial communities and health in humans.However,given that host phytogeny shapes the composition of intestinal microbiota,it is unclear whether this pattern generalizes across phyla.Here,we collected shrimp and water samples from ponds with healthy and diseased shrimp to understand variations in bacteria between habitats(i.e.,water and intestine)and/or health states.The results showed that bacterial communities were clustered according to their original habitats and health states,and a-diversity dramatically decreased in the presence of disease in both habitats.Habitat and health state constrained 14.6%and 7.7%of the variation in bacterial communities,respectively.Changes in shrimp intestinal bacterial communities occurred in parallel with changes in Disease severity,reflecting the transition from a healthy to a diseased state.This pattern was further evidenced by 38 bacterial families that were particularly sensitive to changes in their environment and differed significantly between healthy and diseased shrimp;moderate changes were noted in shrimp with sub-optimal health.In addition,within a given bacterial family,the patterns of enrichment or decrease were consistent with the family’s known functions,enabling us to propose a conceptual model that links imbalances in intestinal microbiota with the emergence of shrimp disease.Additionally,119 indicator species were identified,which yielded a discriminative pattern similar to that based on the whole community.Collectively,this study implies that progressive changes in intestinal bacterial communities are closely associated with shrimp Disease severity and that indicator species could be used to evaluate shrimp health states.

关键词： intestinal microbiota health states Disease severity indicator species

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SARS-CoV-2 viral load in the upper respiratory tract and Disease severity in COVID-19 patients

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World Journal of Meta-Analysis 2022年第4期10卷 195-205页

作者： Wattana Leowattana Tawithep Leowattana Pathomthep Leowattana Department of Clinical Tropical Medicine Faculty of Tropical MedicineMahidol UniversityBangkok 10400Thailand Department of Medicine Faculty of MedicineSrinakharinwirot UniversityBangkok 10110Thailand

Due to the disease's broad clinical spectrum,it is currently unclear how to predict the future prognosis of patients at the time of diagnosis of coronavirus disease 2019(COVID-19).Real-time reverse transcription-polymerase chain reaction(RTPCR)is the gold standard molecular technique for diagnosing COVID-19.The number of amplification cycles necessary for the target genes to surpass a threshold level is represented by the RT-PCR cycle threshold(Ct)values.Ct values were thought to be an adequate proxy for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral load.A body of evidence suggests that SARS-CoV-2 viral load is a possible predictor of COVID-19 severity.The link between SARS-CoV-2 viral load and the likelihood of severe disease development in COVID-19 patients is not clearly elucidated.In this review,we describe the scientific data as well as the important findings from many clinical studies globally,emphasizing how viral load may be related to Disease severity in COVID-19 patients.Most of the evidence points to the association of SARS-CoV-2 viral load and Disease severity in these patients,and early anti-viral treatment will reduce the severe clinical outcomes.

关键词： Severe acute respiratory syndrome coronavirus-2 Viral load Upper respiratory tract Coronavirus disease 2019 patients Disease severity Clinical outcome

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Early Hyperglycemia in Diabetics as a Predictor of Disease severity in COVID-19

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International Journal of Clinical Medicine 2021年第12期12卷 543-550页

作者： Niaz Ahmed Shaikh Arshee Khan Asnin Shah Rubina Inamdar Rania Abosalama Rafeh Jamal Dubai Health Authority Rashid Hospital Dubai UAE

Background: Hyperglycemia is an important predictor of prolonged hospitalization and mortality. The objective of this study was to analyze the role of early hyperglycemia in predicting the severity of COVID-19 illness and mortality. Method: Retrospective study on 259 patients with COVID-19 with measurement of average glucose during 24 hours of admission. Association of Early Hyperglycemia categorized as 180 mg/dl;was studied with mortality, requirement of ICU stay and prognostic markers. Results: Early hyperglycemia (>180 mg/dl) revealed a higher median value for CRP (109 mg/l [IQR;48 - 199]) in comparison to 180 mg/dl group;24 (15.9%) vs 14 patients (13%) [p = 0.51] in the 180 mg/dl was 8 (5.3%) while Conclusion: Hyperglycemia in the first 24 hours may anticipate an increased risk of ICU stay and a higher mortality rate. It may be a possible predictor of Disease severity.

关键词： Admission Hyperglycemia COVID-19 Diabetes Disease severity

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