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Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/Sirt1 axis

BIOCELL 2022年第4期46卷 989-998页

作者： LONGJU QI XIAOYING XU BIN LI BO CHANG SHENGCUN WANG CHUN LIU LIUCHENG WU XIAODI ZHOU QINGHUA WANG Affiliated Nantong Hospital 3 of Nantong University Nantong UniversityNantong226001China Comparative Medicine Institution of Nantong University Nantong UniversityNantong226001China Department of Gynecology and Obstetrics Hai’an Hospital Affiliated to Nantong UniversityNantong UniversityNantong226001China Department of Paediatric Affiliated Hospital of Nantong UniversityNantong UniversityNantong226001China Department of Internal Cardiovascular Medicine the 6th People’s Hospital of Nantong CityNantong226001China

Excessive fat ectopically deposited in the non-adipose tissues is considered as one of the leading causes of *** aim of this study was to investigate the role of Dihydroartemisinin(DHA)in palmitate(PAL)-incubated H9c2 cells(lipotoxicity-induced cell injury model).Cell viability of PAL-treated cells was determined by MTT assay,and apoptotic regulators were examined by qRT-PCR and western blot analysis,in the absence or in the presence of DHA,*** levels of miR-133b and Sirt1 were also evaluated by qRT-PCR and western blotting *** decreased the viability of H9c2 cells and enhanced the expression of apoptotic *** reversed the effect of PAL on cell viability and lowed the level of Caspase3 and *** also lowered the expression of miR-133b,while enhanced the expression of ***1 was revealed as target of miR-133b through transcriptional regulation and the process was affected by *** partially protected against the PAL-induced lipotoxicity by influencing the expression of miR-133b that hindered the activity of *** may be used as a potential treatment in clinical management for lipotoxicity induced heart complications.

关键词： microRNA-133b Palmitate acid Cardiomyocytes Sirt1 dihydroaretemisinin

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