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Insights into the history and tendency of glycosylation and digestive system tumor:A bibliometric-based visual analysis

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1059-1075页

作者： Jie Jiang Zai Luo Ren-Chao Zhang Yue-Ling Wang Jun Zhang Ming-Yu Duan Zheng-Jun Qiu Chen Huang Department of Gastrointestinal Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Jiangnan University Wuxi School of Medicine Wuxi 214122Jiangsu ProvinceChina Department of Education Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological *** the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years,bibliometric analysis of this field remains *** present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system *** To find and identify the developmental trends and research hotspots of glycosylation in digestive system *** We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace(version 6.1.R6)to perform bibliometric *** A total of 2042 documents spanning from 1978 to the present were analyzed,with the research process divided into three phases:the period of obscurity(1978-1990),continuous development period(1991-2006),and the rapid outbreak period(2007-2023).These documents were authored by researchers from 66 countries or regions,with the United States and China leading in terms of publication *** Celso A had the highest number of publications,while Pinho SS was the most cited ***-occurrence analysis revealed the most popular keywords in this field are glycosylation,expression,cancer,colorectal cancer,and pancreatic ***,the Journal of Proteome Research was the most prolific journal in terms of publications,while the Journal of Biological Chemistry had the most *** The bibliometric analysis shows current research focus is primarily on basic research in this ***,future research should aim to utilize glycosylation as a target for treating tumor patients.

关键词： Glycosylation Cancer digestive system Bibliometric analysis CiteSpace VOS viewer

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Blastomas of the digestive system in adults:A review

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1030-1042页

作者： Yu Liu Tony El Jabbour Jonathan Somma Yukihiro Nakanishi Saverio Ligato Hwajeong Lee Zhi-Yan Fu Department of Pathology LSU Health Sciences Center School of MedicineNew OrleansLA 70112United States Department of Pathology Hartford HealthCareHartfordCT 06102United States Department of Pathology Moffitt Cancer CenterTampaFL 33612United States Department of Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States

Blastomas,characterized by a mixture of mesenchymal,epithelial,and undifferentiated blastematous components,are rare malignant neoplasms originating from precursor blast *** review focuses on digestive system blastomas in adult patients,including gastroblastoma,hepatoblastoma,and *** is a biphasic,epitheliomesenchymal tumor,with only sixteen cases reported to *** addition to the characteristic histology,metastasisassociated lung adenocarcinoma transcript 1-glioma-associated oncogene homolog 1 gene fusion is typical,although recently novel ewing sarcoma breakpoint region 1-c-terminal binding protein 1 and patched 1-glioma-associated oncogene homolog 2 fusions have been *** is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic ***,primarily a pediatric tumor,displays acinar differentiation and squamoid nests with other lines of differentiation also present,especially *** approaches for these blastomas include a combination of imaging modalities,histopathological examination,and molecular *** treatment generally involves surgical resection,which may be supplemented by chemotherapy or radiotherapy in some *** vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes,particularly in the setting of *** review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.

关键词： Adult blastomas Gastroblastoma Hepatoblastoma Pancreatoblastoma digestive system

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Molecular physiology of vesicular glutamate transporters in the digestive system

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World Journal of Gastroenterology 2005年第12期11卷 1731-1736页

作者： Fayez K.Ghishan Departments of Pediatrics and Medicine

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Packaging and storage of glutamate into glutamatergic neuronal vesicles require ATP-dependent vesicular glutamate uptake systems, which utilize the electrochemical proton gradient as a driving force. Three vesicular glutamate transporters (VGLUT1-3) have been recently identified from neuronal tissue where they play a key role to maintain the vesicular glutamate level. Recently, it has been demonstrated that glutamate signaling is also functional in peripheral neuronal and non-neuronal tissues, and occurs in sites of pituitary, adrenal, pineal glands, bone, GI tract, pancreas,skin, and testis. The glutamate receptors and VGLUTs in digestivesystem have been found in both neuronal and endocrinal cells. The glutamate signaling in the digestive system may have significant relevance to diabetes and GI tract motility disorders. This review will focus on the most recent update of molecular physiology of digestive VGLUTs.

关键词： Glutamate Vesicular glutamate transporters digestive system

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Excretion and detection of SARS coronavirus and its nucleic acid from digestive system

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World Journal of Gastroenterology 2005年第28期11卷 4390-4395页

作者： Xin-Wei Wang Qing-Xin Kong Zhong Li Nong Song Min Jin Chang-Qing Gu Jing Yin Guo-Rong Ou Fu-Huan Chao Jun-Wen Li Jin-Song Li Bei Zhen Xiao-Ming Wu Wen-Jun Xiao Wei Wei Min-Nian Wang Gui-Jie Wang Ting-Kai Guo Xiu-Mei Zhu Wei Yao Jian-Feng Li Yao-Hui Qiu Huai-Huan Wu Chao Liu Tong-Yu Fang Tianjin Institute of Environment and Health Tianjin 300050 China Institute of Microbiology and Epidemiology Beijing 100072 China Xiao Tang Shan Hospital Beijing 102211 China Bin Yi 309 Hospital of PLA Beijing 100091 China Beijing Institute of Pharmacology and Toxicology Beijing 100850 China Beijing Institute of Basic Medicine Beijing 100850 China

AIM： To study whether severe acute respiratory syndrome coronavirus （SARS-CoV） could be excreted from digestive system.METHODS： Cell culture and semi-nested RT-PCR were used to detect SARS-CoV and its RNA from 21 stool and urine samples, and a kind of electropositive filter media particles was used to concentrate the virus in 10 sewage samples from two hospitals receiving SAILS patients in Beijing in China. RESULTS： It was demonstrated that there was no live SARS-CoV in all samples collected, but the RNA of SARS-CoV could be detected in seven stool samples from SARS patients with any one of the symptoms of fever, malaise, cough, or dyspnea, in 10 sewage samples before disinfection and 3 samples after disinfection from the two hospitals. The RNA could not be detected in urine and stool samples from patients recovered from SARS.CONCLUSION： Nucleic acid of SARS-CoV can be excreted through the stool of patients into sewage system, and the possibility of SARS-CoV transmitting through digestive system cannot be excluded.

关键词： Severe acute respiratory syndrome Nucleic acid digestive system

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Advancements in AI Research for digestive system Diseases

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Journal of Biosciences and Medicines 2023年第12期11卷 173-202页

作者： Qigang Feng Jie Li Xiaoping Tan Qing Zhang Department of Gastroenterology The First People’s Hospital of Yangtze University Jingzhou China digestive Disease Research Institution of Yangtze University Jingzhou China College of Clinical Medical Yangtze University Jingzhou China

With the “boom” of AI, researchers have made significant progress in assisting clinical disease diagnosis, prediction, and treatment. This article provides an overview of models built using both traditional machine learning methods and deep learning methods, as well as research progress on robotics in digestive system diseases, aiming to provide references for further studies. An application has been developed by domestic and foreign scholars that allows users to upload images of stool samples, which are then analyzed using big data to provide a score for bowel preparation, thereby improving the quality of bowel preparation. In some gastrointestinal diseases, such as Hp infection, Barrett’s esophagus and esophageal cancer, chronic atrophic gastritis and gastric cancer, IBD, etc., artificial intelligence possesses diagnostic capabilities comparable to those of professional endoscopists, and some applications can achieve real-time diagnosis. In the field of liver, gallbladder, and pancreatic diseases, artificial intelligence can assist in preoperative diagnosis using imaging or pathology, and robotic remote operations can be performed during surgery, predicting postoperative risk levels, and more. Different scholars have compared and analyzed various algorithm networks for different diseases to find the best-performing models. On this basis, methods such as the MCA attention mechanism, feature selection, gradient descent, and ensemble models can be introduced to further improve the diagnostic performance of the models. In the future, AI can not only help patients self-manage single or multiple diseases, monitor and manage their own diseases in a standardized and reasonable manner, but also predict and treat digestive system diseases at the genetic level.

关键词： AI Deep Learning digestive system Bowel Preparation Medical Imaging Robotics

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Clinical analysis of multiple primary malignancies in the digestive system: A hospital-based study

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World Journal of Gastroenterology 2005年第27期11卷 4215-4219页

作者： Hui-Yun Cheng Cheng-Hsin Chu Wen-Hsiung Chang Tzu-Chi Hsu Shee-Chan Lin Chuan-Chuan Liu An-Ming Yang Shou-Chuan Shih Shih Health Evaluation Center Mackay Memorial hospital TaipeiTaiwan China Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Surgery Mackay Memorial HospitalTaipei Taiwan China Mackay Medicine Nursing and Management College Taipei Taiwan China

AIM： To analyze the characteristics of multiple primary malignancies （MPMs） of digestive system; including incidence, types of tumor combinations, time intervals between development of multiple tumors, clinical course,and prognostic factors affecting survival and ***： Data from a total of 129 patients treated from January 1991 to December 2000 for pathologically proved MPMs, including at least one originating from the digestive system, were reviewed ***： Among 129 patients, 120 （93.02%） had two primary cancers and 9 （6.98%） had three primary cancers. The major sites of MPMs of the digestive system were large intestine, stomach, and liver. Associated nondigestive cancers included 40 cases of gynecological cancers, of which 31 were carcinoma of cervix and 10 cases of genitourinary cancers, of which 5 were bladder cancers. Other cancers originated from the lung, breast,nasopharynx, larynx, thyroid, brain, muscle, and *** tract cancers, especially cervical, ovarian,bladder, and prostate cancers were the most commonlyassociated non-G! cancers, followed by cancer of the lung and breasts. Forty-three cases were synchronous, while the rest （86 cases） were metachronous cancers. Staging of MPMs and treatment regimes correlated with the prognosis between survival and non-survival ***： As advances in cancer therapy bring about a progressively larger percentage of long-term survivors, the proportion of patients with subsequent primary lesions will increase. Early diagnosis of these lesions, based on an awareness of the possibility of second and third cancers, and multidiscipiinary treatment strategies will substantially increase the survival of these patients.

关键词： Multiple primary malignancies digestive system

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COVID-19 and its effects on the digestive system

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World Journal of Gastroenterology 2021年第24期27卷 3502-3515页

作者： Ting-Ting Cao Gu-Qin Zhang Emily Pellegrini Qiu Zhao Jin Li Lin-jie Luo Hua-Qin Pan Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Respiratory and Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Dascena Inc. HoustonTX 77080United States Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina Department of Experimental Radiation Oncology and Surgical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Clinical Research Center of Hubei Critical Care Medicine Wuhan 430071Hubei ProvinceChina

Coronavirus disease 2019(COVID-19)is caused by infection of the coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with typical respiratory ***-CoV-2 invades not only the respiratory system,but also other organs expressing the cell surface receptor angiotensin converting enzyme *** particular,the digestive system is a susceptible target of *** symptoms of COVID-19 include anorexia,nausea,vomiting,diarrhea,abdominal pain,and liver *** with digestive damage have a greater chance of progressing to severe or critical illness,a poorer prognosis,and a higher risk of *** paper aims to summarize the digestive system symptoms of COVID-19 and discuss fecal-oral contagion of *** also describes the characteristics of inflammatory bowel disease patients with SARSCoV-2 infection and discusses precautions for preventing SARS-CoV-2 infection during gastrointestinal endoscopy *** attention to digestive system abnormalities and gastrointestinal symptoms of COVID-19 patients may aid health care providers in the process of clinical diagnosis,treatment,and epidemic prevention and control.

关键词： COVID-19 digestive system Liver function Mechanisms Inflammatory bowel disease Endoscopy

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Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system

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Chinese Journal of Cancer Research 2018年第5期30卷 553-563页

作者： Yanjie Wang Yan Li Kun Yan Lin Shen Wei Yang Jifang Gong Ke Ding Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Ultrasound Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute

Objective： To explore the safety of ultrasound and microbubbles for enhancing the chemotherapeutic sensitivity of malignant tumors in the digestive system in a clinical trial, as well as its ***： From October 2014 to June 2016, twelve patients volunteered to participate in this study. Eleven patients had hepatic metastases from tumors of the digestive system, and one patient had pancreatic carcinoma. According to the mechanical index （MI） in the ultrasound field, patients were classified into four groups with MIs of 0.4, 0.6, 0.8 and 1.0. Within half an hour after chemotherapy, patients underwent ultrasound scanning with ultrasound microbubbles （SonoVue） to enhance the efficacy of chemotherapy. All adverse reactions were recorded and were classified in 4 grades according to the Common Terminology Criteria for Adverse Events version 4.03 （CTCAE V4.03）. Tumor responses were evaluated by the Response Evaluation Criteria in Solid Tumors version 1.1 criteria. All the patients were followed up until ***： All the adverse reactions recorded were level 1 or level 2. No local pain occurred in any of the patients. Among all the adverse reactions, fever might be related to the treatment with ultrasound combined with microbubbles. Six patients had stable disease （SD）, and one patient had a partial response （PR） after the first cycle of treatment. At the end of follow-up, tumor progression was restricted to the original sites, and no new lesions had ***： Our preliminary data showed the potential role of a combined treatment with ultrasound and microbubbles in enhancing the chemotherapeutic sensitivity of malignant tumors of the digestive system. This technique is safe when the MI is no greater than 1.0.

关键词： Clinical study sonoporation microbubbles chemotherapy digestive system

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The regulatory roles of aquaporins in the digestive system

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Genes & Diseases 2021年第3期8卷 250-258页

作者： Shengtao Liao Li Gan Lin Lv Zhechuan Mei Department of Gastroenterology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Teaching and Research Section of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing400016PR China

Aquaporins(AQPs)are highly conserved small transmembrane proteins,which are responsible for the water transport across the cell *** are abundantly expressed in numerous types of cells such as epithelial and endothelial *** expression of AQP-1,-3,-4,-5,-8 and-9 were found in the digestive system,where these six AQP isoforms serve essen-tial roles including mediating the transmembrane water transport and regulating the secretion of gastrointestinal(GI)fluids,consequently facilitating the digestion and absorption of GI *** addition,the expression levels of AQPs are controlled by various factors,and AQPs can stimulate numerous signaling pathways;however,aberrant expression of AQPs in the GI tracts are associated with the initiation and development of numerous ***,this re-view provides an overview of the expression and functions of AQPs in the digestive system.

关键词： Aquaporins digestive system Distribution Function Water transfer

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Nanomedicine strategies for sustained,controlled,and targeted treatment of cancer stem cells of the digestive system

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World Journal of Gastrointestinal Oncology 2016年第10期8卷 735-744页

作者： Fang-Yuan Xie Wei-Heng Xu Chuan Yin Guo-Qing Zhang Yan-Qiang Zhong Jie Gao Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery Hospital Department of Pharmaceutical Sciences School of Pharmacythe Second Military Medical University Department of Biochemical Pharmacy School of Pharmacythe Second Military Medical University Department of Gastroenterology Changzheng HospitalSecond Military Medical University

Cancer stem cells(CSCs) constitute a small proportion of the cancer cells that have self-renewal capacity and tumor-initiating *** have been identified in a variety of tumors,including tumors of the digestive *** exhibit some unique characteristics,which are responsible for cancer metastasis and ***,the development of effective therapeutic strategies against CSCs plays a key role in increasing the efficacy of cancer *** potential approaches to target CSCs of the digestive system have been explored,including targeting CSC surface markers and signaling pathways,inducing the differentiation of CSCs,altering the tumor microenvironment or niche,and inhibiting ATP-driven efflux ***,conventional therapies may not successfully eradicate CSCs owing to various problems,including poor solubility,stability,rapid clearance,poor cellular uptake,and unacceptable *** strategies,which include drug,gene,targeted,and combinational delivery,could solve these problems and significantly improve the therapeutic *** review briefly summarizes the ongoing development of strategies and nanomedicine-based therapies against CSCs of the digestive system.

关键词： Nanomedicine Cancer stem cells digestive system Drug delivery Gene delivery

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