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diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction

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Neural Regeneration Research 2012年第12期7卷 900-905页

作者： Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu Department of Neurology and Gerontology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Radiology Huashan Hospital Fudan University Shanghai 200040 China

To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction. The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days. The diffusion coefficient remained unchanged. Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction.

关键词： corticospinal tracts Wallerian degeneration fractional anisotropy diffusion tensor imaging neuroimaging neural regeneration

diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第4期17卷 838-844页

作者： Wen-Zhu Wang Xu Liu Zheng-Yi Yang Yi-Zheng Wang Hai-Tao Lu China Rehabilitation Science Institute School of Rehabilitation MedicineCapital Medical UniversityBeijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina Department of Rehabilitation Medicine Beijing Friendship HospitalCapital Medical UniversityBeijingChina Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijingChina

At present,predicting the severity of brain injury caused by global cerebral ischemia/reperfusion injury(GCI/RI)is a clinical *** such an injury,clinical indicators that can directly reflect neurological dysfunction are *** change in hippocampal microstructure is the key to memory formation and *** tensor imaging is a highly sensitive tool for visualizing injury to hippocampal *** hippocampal microstructure,brain-derived neurotrophic factor(BDNF),and tropomyosin-related kinase B(Trk B)levels are closely related to nerve injury and the repair process after GCI/RI,whether these indicators can reflect the severity of such hippocampal injury remains *** address this issue,we established rat models of GCI/RI using the four-vessel occlusion *** tensor imaging parameters,BDNF,and Trk B levels were correlated with modified neurological severity *** results revealed that after GCI/RI,while neurological function was not related to BDNF and Trk B levels,it was related to hippocampal fractional *** findings suggest that hippocampal fractional anisotropy can reflect the severity of hippocampal injury after global GCI/*** study was approved by the Institutional Animal Care and Use Committee of Capital Medical University,China(approval ***-2015-139)on November 9,2015.

关键词： brain-derived neurotrophic factor diffusion tensor imaging fractional anisotropy value global cerebral ischemia/reperfusion injury hippocampus Trk B

diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury

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Neural Regeneration Research 2023年第1期18卷 176-182页

作者： Chang-Bin Liu De-Gang Yang Jun Li Chuan Qin Xin Zhang Jun Liu Da-Peng Li Jian-Jun Li Department of Rehabilitation Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Spinal and Neural Function Reconstruction China Rehabilitation Research CenterBeijingChina China Rehabilitation Science Institute BeijingChina Department of Neurosurgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Based on the Wallerian degeneration in the spinal cord pathways,the changes in synaptic connections,and the spinal cord-related cellular responses that alter the cellular structure of the brain,we presumed that brain diffusion tensor imaging(DTI)parameters may change after spinal cord ***,the dynamic changes in DTI parameters remain *** established a Beagle dog model of T10 spinal cord contusion and performed DTI of the injured spinal *** found dynamic changes in DTI parameters in the cerebral peduncle,posterior limb of the internal capsule,pre-and postcentral gyri of the brain within 12 weeks after spinal cord *** then performed immunohistochemistry to detect the expression of neurofilament heavy polypeptide(axonal marker),glial fibrillary acidic protein(glial cell marker),and NeuN(neuronal marker).We found that these pathological changes were consistent with DTI parameter *** findings suggest that DTI can display brain structure changes after spinal cord injury.

关键词： spinal cord injury diffusion tensor imaging canines pathophysiology cerebrospinal structures corticospinal tract magnetic resonance imaging anisotropic fraction apparent dispersion coefficient

diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy

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Neural Regeneration Research 2017年第4期12卷 603-609页

作者： Hong-xin Li Xing Feng Qian Wang Xuan Dong Min Yu Wen-juan Tu Department of Neonatology Children's Hospital of Soochow University Suzhou Jiangsu Province China Department of Neonatology Changzhou Children's Hospital Changzhou Jiangsu Province China School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China Department of Children's Health Research Center Changzhou Children's Hospital Changzhou Jiangsu Province China Nantong University Nantong Jiangsu Province China

With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy （14 moderate cases and 8 severe cases） underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy.

关键词： nerve regeneration fractional anisotropy diffusion tensor imaging apparent diffusion coefficient voxel volume neonatal behavioralneurological assessment brain injury white matter neuroimaging neural regeneration

diffusion tensor imaging with multiple diffusion-weighted gradient directions

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Neural Regeneration Research 2011年第1期6卷 66-71页

作者： Shan Jiang Meixia Liu Tong Han Weihua Liu School of Mechanical Engineering Tianjin University Tianjin 300072 China Medical Image Evaluation Center Tianjin Huanhu Hospital Tianjin 300060 China

diffusion tensor MRI （DT-MRI or DTI） is emerging as an important non-invasive technology for elucidating intemal brain structures. It has recently been utilized to diagnose a series of diseases that affect the integrity of neural systems to provide a basis for neuroregenerative studies. Results from the present study suggested that neural tissue is reconstructed with multiple diffusion-weighted gradient directions DTI, which varies from traditional imaging methods that utilize 6 gradient directions. Simultaneously, the diffusion tensor matrix is obtained by multiple linear regressions from an equation of echo signal intensity. The condition number value and standard deviation of fractional anisotropy for each scheme can be used to evaluate image quality. Results demonstrated that increasing gradient direction to some extent resulted in improved effects. Therefore, the traditional 6 and 15 directions should not be considered optimal scan protocols for clinical DTI application. In a scheme with 20 directions, the condition number and standard deviation of fractional anisotropy of the encoding gradients matrix were significantly reduced, and resulted in more clearly and accurately displayed neural tissue. Results demonstrated that the scheme with 20 diffusion gradient directions provided better accuracy of structural renderings and could be an optimal scan protocol for clinical DTI application.

关键词： diffusion tensor imaging neural tissue tensor matrix multiple linear regression condition number

diffusion tensor imaging of spinal microstructure in healthy adults： improved resolution with the readout segmentation of long variable echo-trains

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Neural Regeneration Research 2017年第12期12卷 2067-2070页

作者： Bu-tian Zhang Meng Li Li-li Yu Yi-meng Dai Shao-nan Yu Jin-lan Jiang China-Japan Union Hospital of Jilin University Changchun Jilin Province China

diffusion tensor imaging plays an important role in the accurate diagnosis and prognosis of spinal cord diseases. However, because of technical limitations, the imaging sequences used in this technique cannot reveal the fine structure of the spinal cord with precision. We used the readout segmentation of long variable echo-trains（RESOLVE） sequence in this cross-sectional study of 45 healthy volunteers aged 20 to 63 years. We found that the RESOLVE sequence significantly increased the resolution of the diffusion images and improved the median signal-to-noise ratio of the middle（C4–6） and lower（C7–T1） cervical segments to the level of the upper cervical segment. In addition, the values of fractional anisotropy and radial diffusivity were significantly higher in white matter than in gray matter. Our study verified that the RESOLVE sequence could improve resolution of diffusion tensor imaging in clinical applications and provide accurate baseline data for the diagnosis and treatment of cervical spinal cord diseases.

关键词： nerve regeneration diffusion tensor imaging cervical spinal cord microstructure gray matter white matter readout segmentationof long variable echo-train sequence signal-to-noise ratio fractional anisotropy neural regeneration

diffusion tensor imaging reveals brain abnormality patterns in a patient with semantic dementia

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Neural Regeneration Research 2010年第2期5卷 142-145页

作者： Qiang Yuan Qin Chen Hehan Tang Xintong Wu Qiyong Gong Dong Zhou Ling Zou Department of Neurology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China Huaxi Magnetic Resonance Research Center Department of Radiology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China Division of Medical imaging Faculty of Medicine University of Liverpool Liverpool L69 3GB UK

BACKGROUND： Previous studies regarding primary progressive aphasia （PPA） have focused on progressive, non-fluent aphasia. Little information is available with regard to the use of diffusion tensor imaging compared with conventional magnetic resonance imaging for the detection of subtle structural abnormalities. OBJECTIVE： To investigate and localize brain abnormalities in a Chinese patient with semantic dementia. DESIGN, TIME AND SETTING： A concurrent, non-randomized, case-controlled, neuroimaging, clinical trial was performed at the Department of Radiology, West China Hospital of Sichuan University in March 2009. PARTICIPANTS： One 75-year-old male patient, who was diagnosed with semantic dementia, and 21 age- and gender-matched healthy volunteers were recruited for the study. METHODS： diffusion tensor imaging was used to determine mean diffusion （MD） and fractional anisotropy （FA） in the brains of the patient and the 21 healthy subjects. Voxel-based analysis of MD and FA values was performed using statistical parametric mapping. MAIN OUTCOME MEASURES： MD and FA value maps differences between patient and controls. RESULTS： MD was significantly increased in both cerebra, but was predominant on the left side and expanded to outside of the language-related region. Reduced MD was not detected in any of the brains. FA was shown to be decreased in the corpus callosum, but was increased in the basal ganglia. CONCLUSION： The present study provided clear in vivo magnetic imaging evidence of diffuse brain involvement in semantic dementia. Increases in MD were greater than in FA when brain diffusion alterations were detected, which suggested that MD could be a better marker of disease progression.

关键词： semantic dementia primary progressive aphasia diffusion tensor imaging mean diffusion fractional anisotropy voxel-based analysis

diffusion tensor imaging study of fractional anisotropy values and the area of both cerebral peduncles in healthy adults

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Neural Regeneration Research 2011年第10期6卷 797-800页

作者： Zhibin Song Suyue Pan Yanling Zhou Yanjiang Dong Haimao Liang Zhengfeng Zhu Department of Neurology Xiaolan Hospital of Southern Medical University Zhongshan 528415 Guangdong Province China Department of Neurology Nanfang Hospital of Southern Medical University Guangzhou 510515 Guangdong Province China

diffusion tensor imaging was performed in 105 volunteers free of central nervous system *** differences were found in fractional anisotropy between the left and right cerebral peduncles among subjects（P 0.05）.The lower limit value of fractional anisotropy was 0.36,and the asymmetry ratio was *** area and lower limit value of the cerebral peduncles were 0.90 cm2 and 0.83,*** results will be useful in evaluating the diagnosis of Wallerian degeneration following cerebral infarction.

关键词： healthy Chinese people cerebral peduncle fractional anisotropy area diffusion tensor imaging

diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects

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World Journal of Clinical Cases 2022年第24期10卷 8450-8462页

作者： Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia Department of Radiology School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia School of Computer Sciences Universiti Sains Malaysia11800 USMPenangMalaysia Department of Neurosciences Hospital Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia

Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of *** a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain *** relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in *** tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter ***,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical *** this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals.

关键词： diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing Tractography