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DEC1 nuclear expression:A marker of differentiation grade in hepatocellular carcinoma

World Journal of Gastroenterology 2011年第15期17卷 2037-2043页

作者： Xiao-Hong Shi Yan Zheng Qing Sun Jing Cui Qing-Hua Liu Fei Qü Yun-Shan Wang Department of Laboratory Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan 250014 Shandong Province China Shandong Province Key Lab of Tumor Target Molecule Jinan Central Hospital Affiliated to Shandong University Jinan 250013 Shandong Province China Central Laboratory Jinan Central Hospital Affiliated to Shandong University Jinan 250013 Shandong Province China Department of Pathology Shandong Provincial Qianfoshan Hospital Shandong University Jinan 250014 Shandong Province China Department of Respiratory Provincial Hospital Affiliated to Shandong University Jinan 250021 Shandong Province China Department of Pathology Jinan Central Hospital Affiliated to Shandong University Jinan 250013 Shandong Province China Medical Research and Laboratory Diagnostic Center Jinan Central Hospital Affiliated to Shandong University Jinan 250013 Shandong Province China

AIM: To investigate the expression patterns of human differentiated embryo chondrocyte 1 (DEC1) in hepatocellular carcinoma (HCC) and corresponding adjacent non-tumor and the normal liver tissues, the association between DEC1 expression and histopathological variables and the role of DEC1 in hepatocarcinogenesis. METHODS: The expression of DEC1 was detected immunohistochemically in 176 paraffin-embedded sections from 63 patients with HCC and 50 subjects with normal liver tissues. RESULTS: DEC1 protein was persistently expressed in the cytoplasm of hepatocytes in normal liver and HCC tissues. Compared with adjacent non-tumor liver tissues, HCC tissues showed high nuclear expression of DEC1 protein. However, high DEC1 nuclear expression was more frequently detected in well-differentiated (83.3%) than in moderately (27.3%) and poorly differentiated HCC (16.7%). Low DEC1 expression was associated with poor histological differentiation and malignancy progression. A correlation was found between the nuclear expression of DEC1 protein and histological differentiation (r = 0.376, P = 0.024). CONCLUSION: DEC1 is expressed in the cytoplasm of hepatocytes and because nuclear DEC1 expression is decreased with decreasing differentiation status of HCC, nuclear DEC1 might be a marker of HCC differentiation.

关键词： differentiated embryo chondrocyte 1 Hepatocellular carcinoma Differentiation Immunohistochemistry

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