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Embryonic skeleton development and neonatal learning and memory ability of rats anesthetized with pentobarbital sodium: differences of administration occasion and time

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Neural Regeneration Research 2006年第9期1卷 844-846页

作者： Changling Peng Yuhua Zhu Ankang Hu Xiaorong Zhu Experimental Animal Center Xuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China

BACKGROUND: Generally speaking, anesthesia is often used in gravid body and it has been already proved that many kind of medicine can result in malformation. OBJECTIVE: To explore embryonic skeleton development and neonatal learning and memory of rats anesthetized with pentobarbital sodium in gravid rats. DESIGN: A randomized control trial. SETTING: Laboratory Animal Center of Xuzhou Medical College. MATERIALS: A total of 80 adult female SD rats, of clean grade and weighing 220-240 g, were selected in this study. The main reagents were detailed as follows: pentobarbital sodium (Shanghai Xingzhi Chemical Plant, batch number: 921019); MG-2 maze test apparatus (Zhangjiagang Biomedical Instrument Factory); somatotype microscope (Beijing Taike Instrument Co., Ltd.). METHODS: ① A total of 160 SD rats of half males and females were selected in this study. All rats were copulated. The day that the plug was checked out in the vagina next day was looked as the first day of pregnancy. Gravid rats were divided randomly into four groups, including early anesthesia group, second anesthesia group, late anesthesia group and control group with 20 in each group. Rats in the early anesthesia group were injected with 25 mg/kg soluble pentobarbitone on the 7th day of pregnancy for once; rats in the second anesthesia group were anesthetized with 25 mg/kg soluble pentobarbitone on the 7th and the 14th days of pregnancy for once; rats in the late anesthesia group were anesthetized with 25 mg/kg soluble pentobarbitone on the 14th day of pregnancy for once; rats in the control group did not treat with anything. The time of anesthetizing was controlled in 3 to 4 hours and ether was absorbed while the time was not enough. ② Half of each group was sacrificed on day 20th of pregnancy and the fetus was taken out to be stained with alizarin red S. After stained, the fetal skeleton was examined. The learning and memorizing of one-month rats that were given birth by the rest gravid rats were tested

关键词： Embryonic skeleton development and neonatal learning and memory ability of rats anesthetized with pentobarbital sodium differences of administration occasion and time

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