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A Systematic Review of the Efficacy and Safety of didroxyprogesterone Combined with Progesterone in the Treatment of Luteal Insufficiency-Induced Abortion

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Journal of Clinical and Nursing Research 2021年第4期5卷 58-63页

作者： Yanjing Yang Hongli Zhu Shaanxi University of traditional Chinese medicine Xianyang 712046Shaanxi ProvinceChina Affiliated Hospital of Shaanxi University of traditional Chinese medicine Xianyang 712046Shaanxi ProvinceChina

Objective:To systematically evaluate the efficacy and safety of didroxyprogesterone combined with progesterone in the treatment of luteal insufficiency ***:We searched CNKI database,VIP database,Wanfang database,PubMed database,EMBASE database and Cochrane library database for literatures on the treatment of luteal insufficiency-induced abortion with didroxyprogesterone and ***-analysis was performed using Revman 5.3 software after literature extraction and further quality ***:Ten randomized controlled trial-related articles that describe studies on a total of 1145 patients,570 in the combination group and 575 in the control group,were *** results of meta-analysis showed that combination therapy could improve the effective rate of fetal protection(OR=0.14,95%CI[0.07,0.27],P<0.00001).The safety of the combination group was significantly higher than that of the control group(OR=3.09,95%CI[1.13,8.48],P=0.03).Conclusion:To sum up,compared with the control group,the combination of progesterone and progesterone is more effective and safer in the treatment of luteal insufficiency ***,the sample size of the data is relatively small and the quality of the literature is *** conclusion still needs to be further verified in high-quality randomized controlled trials that involve large samples.

关键词： Luteal insufficiency-induced abortion didroxyprogesterone Progesterone Meta-analysis

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