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New Insights in the Skin Protective Activity of a Dexpanthenol Containing Formula (BEPANTHEN<sup>®</sup>) in a diaper rash-Like Model

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第2期10卷 76-84页

作者： Erwan Peltier Karim Mekideche Jean-Eric Branka Sonja Trapp Bayer Consumer Care AG Research & Development Consumer Health Medical Category Dermatology Basel Switzerland Ephyscience Nantes France

Background: Dexpanthenol containing formula (BEPANTHEN®), formulated as a water in oil preparation, is currently widely marketed as a diaper care product aiming to protect baby’s buttocks and repair diaper dermatitis. Dexpanthenol is a well-known moisturizer with barrier-improving properties and the oily phase of the water in oil preparation forms a lipophilic film on the skin surface that isolates the skin from irritants (feces and urine). Prolonged contact with irritants triggers a local inflammation cascade responsible for the cutaneous erythema. To further investigate the protective properties of skin barrier preparations, we took advantage of an ex vivo model of healthy human skin discs especially designed to evaluate protective and/or repairing effects of topical preparations recommended for baby’s buttocks through the measurement of interleukin-1 alpha release (a cytokine considered as the Primum movens of the skin inflammatory reaction), following the application of different irritants. Methods: Healthy human skin discs have been incubated in the absence (control) or in the presence of two irritants, i.e. a “urine like + urease” preparation and sodium dodecyl sulfate, and in the presence of three ointments, one containing dexpanthenol, but not the other two. At the end of the incubation period, interleukin-1 alpha (IL-1α) was quantified in the explants culture media. Results: “Urine like + urease” preparation (ULU) and sodium dodecyl sulfate (SDS) both increased IL-1α production of skin explants by 181.1% (p α release by 67.42% (p α

关键词： Dexpanthenol BEPANTHEN® Human Skin Protection Interleukin-1 diaper-rash

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