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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i>Incorporation of Phospholipids

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Journal of Biophysical Chemistry 2017年第3期8卷 23-38页

作者： Franciane S. Marques Alysson Luiz M. Da Silva Ricardo J. C. Mattoso Roque Aras Rogério Jorge B. De Oliveira Júlio Cézar De Abreu Santos Fabio D. Couto Ricardo D. Couto PGBSMI/Goncalo Moniz Research Center (CPqGM) FIOCRUZ Foundation Center Salvador Brazil Department of Biofunction Health Institute of Science Federal University of Bahia/UFBA Salvador Brazil Clinical Biochemistry Laboratory Department of Clinical and Toxicological Analysis Faculty of Pharmacy Federal University of Bahia/UFBA Salvador Brazil Ana Neri Hospital SESAB and Federal University of Bahia/UFBA Salvador Brazil Naval Hospital of Salvador Brazilian Marine Forces Salvador Brazil Laboratory of Molecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences (CCAAB-UFRB) Cruz das Almas Brazil

End stage-renal-disease (ESRD) is associated with dyslipidemia and premature atherosclerosis. The study evaluates the effect of hemodialysis (HD) on HDL-remodeling between pre- and post-HD. Was conducted a cross-sectional study with 50 ESRD male patients, undergoing HD at Ana Neri Hospital, Salvador, Brazil. All individuals were on HD for at least 3 months, into a three sessions protocol for 3 - 4 hours per week, with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin. HDL Phospholipid-incorporation was measured by 14C-PL-scintillation-counting, expressed as %14C-PL/mL/hour. Paraoxonase (PON-1) activity was measured by spectrophotometry using paraoxon as substrate. Cardiovascular risk ratios and atherogenic index of plasma were calculated. Total cholesterol, HDL-C and non-HDL-C increased at post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased in 30 - 39 and 40 - 49 year (y) at post-HD (p 0.05). LDL-C/apoB increased in >60 y, after HD (p 60 (p 0.01). On the other hand, non-HDL-C/HDL-C reduced in 40 - 49 and >60 y, at post-HD (p 0.05). The linear-correlation between %14C-PL-incorporation and non-HDL-C/HDL-C was negative in 30 - 39 y, both at pre-HD (r = -0.90;p = 0.002) and post-HD (r = -0.78;p = 0.022). Linear-correlation between PON-1 and %14C-PL-incorporation was positive in >60 y, both at pre- (r = 0.63;p = 0.029) and post-HD (r = 0.65;p = 0.022). PON-1 activity increased at pre- (59 ± 30) and post-HD (73 ± 38) in 50 - 59 y (p 0.05). The %14C-PL-incorporation was reduced in >60 y (p 0.05), when compared to pre- and post-HD. ESRD patients undergoing HD shows important changes on lipid-profile, PON-1-activity, cardiac risk ratios and HDL-remodeling. These results demonstrate the influence of HD with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin on lipoprotein metabolism.

关键词： Hemodialysis Dyslipidemia Cardiovascular Risk Bioindices PLTP PON-1 HDL-Remodeling Low-Flow Polysulfone dialyzing-membrane

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