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Delayed diagnosis in inflammatory bowel disease:Time to consider solutions

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World Journal of Gastroenterology 2024年第35期30卷 3954-3958页

作者： Hao Lv Hao-Yu Li Hao-Nan Zhang Yang Liu Department of General Surgery Xi'an Jiaotong University Second Affiliated HospitalXi'an 710004Shaanxi ProvinceChina

In this editorial,we discuss a recently published manuscript by Blüthner et al in the World Journal of Gastroenterology,with a specific focus on the delayed diagnosis of inflammatory bowel disease(IBD).IBD,which includes Crohn's disease and ulcerative colitis,is a chronic intestinal disorder.A time lag may exist between the onset of inflammation and the appearance of signs and symptoms,potentially leading to an incorrect or delayed diagnosis,a situation referred to as the delayed diagnosis of *** diagnosis is crucial for effective patient treatment and prognosis,yet delayed diagnosis remains *** reasons for delayed diagnosis of IBD are numerous and not yet fully *** key factor is the nonspecific nature of IBD symptoms,which can easily be mistaken for other ***,the lack of specific diagnostic methods for IBD contributes to these *** diagnosis of IBD can result in numerous adverse consequences,including increased intestinal damage,fibrosis,a higher risk of colorectal cancer,and a decrease in the quality of life of the ***,it is essential to diagnose IBD promptly by raising physician awareness,enhancing patient education,and developing new diagnostic methods.

关键词： Inflammatory bowel disease Delayed diagnosis diagnostic methods Early diagnosis Consequences of inflammatory bowel disease

Development and refinement of diagnostic and therapeutic strategies for managing patients with cardiogenic stroke:An arduous journey

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World Journal of Clinical Cases 2023年第4期11卷 719-724页

作者： Ze-Xin Fan Ri-Xia Liu Guang-Zhi Liu Department of Neurology Beijing Anzhen HospitalBeijing 100029China

Cardioembolic stroke,referred to as cardiogenic stroke,is a clinical syndrome in which emboli from the heart pass through the circulatory system and cause cerebral artery embolism and corresponding brain *** to other subtypes of ischemic stroke,cardiogenic stroke presents with more etiologies,greater severity,worse prognosis,and a higher recurrence *** this minireview,we provide new insights into the etiological classification,diagnostic methods,and interventions of cardiogenic stroke.

关键词： Cardiogenic stroke diagnostic methods Therapeutic strategies

Present status of aquaculture and the challenge of bacterial diseases in freshwater farmed fish in Tanzania;A call for sustainable strategies

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Aquaculture and Fisheries 2021年第3期6卷 247-253页

作者： Alexanda Mzula Philemon N.Wambura Robinson H.Mdegela Gabriel M.Shirima Department of Global Health and Biomedical Sciences School of Life Science and BioengineeringNelson Mandela African Institution of Science and TechnologyArushaTanzania College of Veterinary Medicine and Biomedical Sciences Sokoine University of AgricultureMorogoroTanzania

Aquaculture provides significant contributions to household food security,as the capture of wild fish from lakes,dams,and oceans do not meet the current demand for animal protein in *** aquaculture requires well-established regulatory systems and extension services for good pond management practices and maintaining fish health by fish *** farming is practiced widely in Tanzania,from small-to large-scale ponds and these farming systems are moving from extensive normal operations(low input demand)to intensive farming(high input demand).However,the industry is largely still operating at a subsistence level with low *** infections have been occurring in these fish farms and will continue to be an issue of concern into the *** review highlights the current challenges,successes,and prospects towards a sustainable aquaculture industry in Tanzania,including:limited extension services mirroring the limited knowledge by farmers regarding pond management practices;the inadequacy of funds to carry out fish disease research or implement a surveillance system;little expertise in fish disease diagnosis and treatment;and poor management *** minimize disease outbreaks and optimize production in the future,we suggest a strengthening of extension services,augmented with on-farm knowledge *** should be on pond management practices and fish disease management;the creation of a well-functioning fish disease surveillance system;and strengthening collaborative research on aquaculture between the government research institutions and *** small cooperative fish farmer groups within the Aquaculture Association of Tanzania(AAT)for easy access to information is also recommended.

关键词： Bacterial diseases diagnostic methods Freshwater Farmed fish Challenges Surveillance

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment

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Chinese Medical Journal 2020年第14期133卷 1655-1661页

作者： Yan-Bo He Ying-Ying Su Gary BRajah Ying-Bo Zhang Un-Lin Fan Gang Liu Hong-Bo Chen Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology The Beijing Moslem People's HospitalBeijing 100054China Department of Neurosurgery Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNY 14201USA Department of Neurosurgery Gates Vascular Institute at Kaleida HealthBuffaloNY 14201USA.

Background:Early neurologic deterioration(END)may occur in patients with anterior circulation ischemic stroke(ACIS)after receiving endovascular treatment(EVT).Hemodynamic insufficiency,re-occlusion,and post-re-canalization hyper-perfusion are likely to play a critical role in *** hypothesized that hemodynamic changes can predict END in patients with ACIS postsuccessful EVT using trans-cranial Doppler(TCD).methods:We utilized a prospectively maintained database of ACIS patients treated with EVT between September 2016 and June 2018 in the Xuanwu Hospital,Capital Medical *** parameters including peak systolic velocity(PSV),bilateral mean flow velocity(MFV),and pulse index(PI)were determined via the middle cerebral arteries within 72 h post-EVT.A logistic regression model was applied to detect independent predictors for ***:Totally,112 EVT patients were included in this study and 80/112 patients experienced successful re-canalization with<50%residual stenosis,while 17/80(21.3%)patients suffered END,for which vasogenic cerebral edema(11/17)was considered as a leading role and followed by symptomatic intra-cranial hemorrhage(4/17)and ischemia progression(2/17).For the 80 patients,the PSV(median:127 cm/s vs.116 cm/s,P=0.039),the ratio of ipsilateral-MFV/contra-lateral-MFV(iMFV/cMFV)(median:1.29 vs.1.02,P=0.036)and iMFV/mean blood pressure(MBP)(median:0.97 vs.0.79,P=0.008)in END patients were higher than those of *** the receiver-operating characteristic curve to obtain cut-off values for PSV,PI,iMFV/cMFV,and iMFV/MBP for END,we found that PI≥0.85(odds ratio:11.03,95%confidence interval:1.92–63.46,P=0.007)and iMFV/MBP≥0.84(odds ratio:9.20,95%confidence interval:2.07–40.84,P=0.004)were independent predictors of END in a multivariate logistic regression model,with a sensitivity of 82.4%and 76.5%and a specificity of 42.9%and 66.7%,respectively,and had the positive predictive values of 29.0%and 38.2%,and negative predictive values of 90.0%and 91.

关键词： Cerebrovascular disease/acute ischemic stroke Endovascular treatment Thrombectomy diagnostic methods Transcranial Doppler

Traditio,nal East Asian Medicine:How to Understand and Approach diagnostic Findings and Patterns in A Modern Scientific Framework?

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Chinese Journal of Integrative Medicine 2014年第5期20卷 336-340页

作者： Stephen Birch Terje Alraek University College of Health Sciences-Campus Kristiania OsloNorway National Research Centre in Complementary and Alternative Medicine UiT The Arctic University of NorwayTromsoNorway

Research into the diagnostic methods and patterns of traditional East Asian medical （TEAM） systems of practice such as acupuncture and herbal medicine face certain challenges due to the nature of thinking in TEAM and the subjective basis of judgments made in practice. The TEAM-based diagnosis can take into account various findings and signs such as the appearance of the tongue, palpable qualities of the radial pulses, palpable qualities and findings on the abdomen, the complexion of the patient and so on. Both diagnostic findings and the patterns of diagnosis cannot be assumed to have objective bases or to be causally related to the complaints of the patient. However, the diagnoses of TEAM based acupuncture and herbal medicine have tended to look at pictures of the whole patient and rather than focus on a particular symptom, they have looked across a myriad of signs and symptoms to decide or identify the ＇pattern＇ of diagnosis according to the theory in question. Although open for selective and subjective biases each diagnosis pattern always comes with a prescribed treatment tailored to the pattern. Further, the same research requirements needed for the validation of the diagnoses are needed also for these clinical observations and judgments. Hence, it is necessary, albeit challenging for research on TEAM diagnoses to first address these issues before proceeding to more complex investigations such as the development of instruments for making diagnostic observations, instruments for forming diagnostic conclusions or studies investigating the physiological bases of the diagnostic patterns. Preliminary work has started and instruments have been made, but we suggest that any instrumentation must necessarily be first validated by matching of the calibrated or scaled observations or judgments to observations made and agreed upon by relevant experts. Reliability of all observations and judgments are needed before any other tool, technology or more advanced approach can pro

关键词： research diagnosis diagnostic methods pattern identification reliability traditional East Asian medical systems

Pivotal role of exosomes in diagnosis and treatment of esophageal cancer in a new era of precision medicine

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World Journal of Methodology 2024年第1期14卷 1-5页

作者： Grigorios Christodoulidis Konstantinos Eleftherios Koumarelas Marina Nektaria Kouliou Department of General Surgery University Hospital of LarissaLarissa 41110Greece

In this editorial we comment on the article published by Ning et al,“Role of exosomes in metastasis and therapeutic resistance in esophageal cancer”.Esophageal cancer(EC)represents a significant global health concern,being the seventh most common and sixth in terms of mortality *** the advances in therapeutic modalities,the management of patients with EC remains challenging,with a 5-year survival rate of only 25%and a limited eligibility for curative surgery due to its late *** screening methods are impractical for the early detection of EC,given their either invasive or insensitive *** advent of liquid biopsy,with a focus on circulating tumor cells,circulating tumor DNA,and exosomes,heralds a non-invasive avenue for cancer ***,small vesicles involved in intercellular communication,are highlighted as potential biomarkers for EC diagnosis and *** with a diverse cargo encompassing various types of RNA,DNA molecules,proteins,and metabolites,exosomes emerge as key players in tumorigenesis,tumor development,and *** significance extends to carrying distinctive biomarkers,including microRNAs(miRNAs),long non-coding RNAs,and circular RNAs,underscoring their potential diagnostic and prognostic ***,exosomes may be utilized for therapeutic purposes in the context of EC treatment,serving as efficient delivery vehicles for therapeutic agents such as chemotherapeutic medicines and *** this editorial we delve into the applications of exosomes for the early detection and treatment of EC,as well as the future perspectives.

关键词： Exosomes Esophageal cancer diagnostic methods Novel therapies

Diagnosis and Prevention of Duck Virus Enteritis

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Animal Husbandry and Feed Science 2019年第5期11卷 153-156页

作者： Pan Xiaocheng Zhao Ruihong Shen Xuehuai Yin Lei Zhang Danjun Da Yin Institute of Animal and Veterinary Science Anhui Academy of Agricultural SciencesHefei 230031China Livestock and Poultry Epidemic Disease Research Center of Anhui Province Hefei 230031China

The characteristics of duck virus enteritis(DVE)are introduced from the aspects of pathogen,epidemiology,clinical symptoms,autopsy pathological changes,etc.,and clinical comprehensive diagnosis and laboratory diagnosis methods are *** disease is distinguished from similar diseases including duck necrotic enteritis,duck candidiasis,duck hemorrhage,duck coccidiosis and duck vitamin A ***,the prevention and treatment measures of the disease are put forward.

关键词： Duck virus enteritis Pathogen Epidemiology Clinical symptoms Necropsy diagnostic methods Prevention and control measures

Diagnosis and Prevention of Colibacillosis in Chickens

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Animal Husbandry and Feed Science 2019年第5期11卷 149-152页

作者： Shen Xuehuai Zhang Danjun Zhao Ruihong Pan Xiaocheng Yin Lei Hu Xiaomiao Institute of Animal and Veterinary Science Anhui Academy of Agricultural SciencesHefei 230031China Livestock and Poultry Epidemic Disease Research Center of Anhui Province Hefei 230031China

The characteristics of chicken colibacillosis are introduced from the aspects of pathogen,epidemiology,clinical symptoms and necropsy,and clinical comprehensive diagnosis and laboratory diagnosis methods are *** disease is distinguished from diseases with similar symptoms such as chicken chlamydia,chicken streptococcus,chicken necrotic enteritis,broiler ascites syndrome and chicken paratyphoid ***,the preventive and therapeutic measures against the disease are put forward.

关键词： Chicken colibacillosis Pathogen Epidemiology Clinical symptoms Necropsy diagnostic methods Prevention and control measures

Comparisons of methods for Pregnancy Diagnosis in Female Poodles

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Agricultural Biotechnology 2015年第6期4卷 43-45页

作者： Heshuang DI Shanshan JIANG Aifeng CHEN Lihua WANG Jundong LIU Jiangsu Agri-animal Husbandry Vocational College

In this study, five 2 -4 years old healthy female poodles were selected and mated after spontaneous estrus for pregnancy diagnosis with external observa- tion, human chorionic gonadotropin colloidal gold rapid test strips （human early pregnancy test strips）, ultrasonic diagnosis and blood routine examination. Accord- ing to the results, female dogs showed abdominal circumference increment and mammogenesis from a month post-mating to parturition and lactated before parturi- tion. At 5, 6, 7, 15, 25 and 35 d post-mating, pregnancy diagnosis with human chorionic gonadotropin colloidal gold rapid test strips showed negative results. Hu- man early pregnancy test strips can not be used for pregnancy diagnosis in female dogs. Currently, ultrasonic method is the most accurate method to diagnose preg- nancy in female dogs, and the optimal diagnosis time is the 30th d post-mating. External observation and blood routine examination can be used as auxiliary methods to diagnose pregnancy in female dogs.

关键词： Poodle Pregnancy Ultrasound diagnostic methods