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Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma

World Journal of Gastroenterology 2008年第7期14卷 1097-1101页

作者： Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz Department of Internal Medicine Ⅱ Technical University of Munich Munich 81675 Germany Department of Pathology Technical University of Munich Munich 81675 Germany

AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar ***: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between ***: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings.

关键词： Brush cytology Forceps biopsy Cholangiocarcinoma Klatskin tumor Endoscopy diagnostic approaches

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