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Current Status and Challenge of Pseudorabies Virus Infection in China

Virologica Sinica 2021年第4期36卷 588-607页

作者： Lei Tan Jun Yao Yadi Yang Wei Luo Xiaomin Yuan Lingchen Yang Aibing Wang Laboratory of Animal Disease Prevention and Control and Animal Model Hunan Provincial Key Laboratory of Protein Engineering in Animal VaccinesCollege of Veterinary MedicineHunan Agricultural University(HUNAU)Changsha410128China PCB Biotechnology LLC RockvilleMD20852USA Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory Yunnan Animal Science and Veterinary InstituteKunming650224China Department of Animal Science and Technology Huaihua Vocational and Technical CollegeHuaihua418000China

Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,etc.,thereby causing severe clinical symptoms and acute *** was firstly reported in China in 1950s,while outbreaks of emerging PRV variants have been documented in partial regions since 2011,leading to significant economic losses in swine *** scientists have been devoting to the design of diagnostic approaches and the development of vaccines during the past years,PR remains a vital infectious disease widely prevalent in Chinese pig ***,its potential threat to human health has also attracted the worldwide *** this review,we will provide a summary of current understanding of PRV in China,mainly focusing on PRV history,the existing diagnosis methods,PRV prevalence in pig population and other susceptible mammals,molecular characteristics,and the available vaccines against its ***,promising agents including traditional Chinese herbal medicines and novel inhibitors that may be employed to treat this viral infection,are also discussed.

关键词： Pseudorabies virus(PRV) diagnosis methods Prevalence Multiple-species infection Prevention and control measures

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American tegumentary leishmaniasis mimicking myiasis and granulomatous vasculitis:A case report

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 473-476,I0001,I0002页

作者： Victoria J Arrieta Gastón Morea Leticia M Tennerini María VSanchez Esteban S Lozano Diego E Cargnelutti Instituto de Medicina y Biología Experimental de Cuyo(IMBECU) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Universidad Nacional de Cuyo(UNCuyo)MendozaArgentina Hospital Luis C.Lagomaggiore MendozaArgentina Facultad de Ciencias Médicas(FCM) Universidad Nacional de Cuyo(UNCuyo)MendozaArgentina

Rationale:American tegumentary leishmaniasis comprises cutaneous and mucocutaneous manifestations caused by parasitic infections by various Leishmania *** report details the clinical interventions for a patient with American tegumentary leishmaniasis in Mendoza,Argentina,a non-endemic *** concerns:A 43-year-old male was admitted to a tertiary care hospital in Mendoza,Argentina Republic with a history of progressive nasal discharge,septal perforation,facial pain,and *** treatment for presumed nasal myiasis and vasculitis with granulomatosis,symptoms ***:American tegumentary ***:Intravenous liposomal amphotericin ***:Follow-up at 30 days showed no recurrence of symptoms with a remarkable clinical improvement of the nasal ***:This case sheds light on the necessity of accurate identification for timely intervention and the need to recognize the diverse manifestations of American tegumentary leishmaniasis to avoid misdiagnosis.

关键词： Leishmania American tegumentary leishmaniasis diagnosis methods Myasis Vasculitis and granulomatosis Case report

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Comparison of Four Diagnostic Tests methods for the Detection of Dengue Virus Non-Structural-1 Antigen and IgM/IgG Antibodies

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Journal of Biosciences and Medicines 2022年第5期10卷 179-190页

作者： Moses N. Ikegbunam Ifeyinwa T.O. Onochie-Igbinedion Nzube F. Ekpunobi Abone Harrison Enyi Emmanuel Simon Nkpeh Ushie Micheal U. Adiukwu Charles O. Esimone Department of Pharmaceutical Microbiology and Biotechnology Nnamdi Azikiwe University Awka Nigeria Molecular Research Foundation for Students and Scientists Nnamdi Azikiwe University Awka Nigeria Department of Medical Microbiology Nnamdi Azikiwe University Awka Nigeria Department of Pharmaceutics University of Nigeria Nsukka (UNN) Nsukka Nigeria

Objectives: Dengue virus (DENV) infection is a mosquito-borne disease that stands out as one of the major public health issues and has a wide-ranging geographical distribution throughout the tropics and subtropics. The general alarming increase in the number of cases over the last two decades can be attributed to an extent by the change in national practices to keeping records and reporting dengue to the Ministries of Health, and WHO. Dengue diagnosis is routinely carried out by detection of dengue virus (DENV) antigen NS1 (Non-structural Antigen 1) and/or anti-DENV IgM/IgG antibodies using enzyme-linked immunosorbent assays (ELISAs) and rapid diagnostic tests (RDTs). This study compared the performance of three RDTs and one ELISA used for dengue diagnosis in southeastern, Nigeria. Design: This study adopted a cross-sectional design that included prospective hospital-based surveillance of cases among febrile participants attending two major health facilities within the southeastern region of Nigeria. In this study, 338 HIV-infected participants from two teaching hospitals in Nigeria’s southeast were systematically tested for Dengue with four methods: NS1 RDT, IgG RDT, IgM RDT, and NS1 ELISA. Their specificities and sensitivities were compared, as well as their level of concordance. Their respective performances were also evaluated using the Receivers Operational curve (ROC). Results: Out of the 338 patients, the dengue prevalence from the four dengue diagnostic methods Dengue virus NS1 ELISA, NS1 RDT, IgM and IgG seropositivity were 8.9%, 0.6%, 5.6%, and 8.0%, respectively. The Dengue IgM RDT test indicated 36.8% sensitivity, 92.8% specificity, the IgG anti-dengue specific test indicated 29.6% sensitivity, 92.9% specificity and the dengue NS1 RDT test indicated 3.3% sensitivity, 99.4% specificity when compared with the Dengue NSI Elisa test method as a reference method. Conclusion: The use of NSI ELISA for DENV diagnosis showed good performance and the RDTs showed,

关键词： Dengue Virus diagnosis methods Comparison Performance Southeastern Nigeria

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Advances in Animal Toxoplasmosis

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Agricultural Biotechnology 2014年第3期3卷 33-35页

作者： Yan JIA Yuesheng LIU Haihong WU Agricultural and Environmental Branch Jiaxing Vocational Technical College

Toxoplasmosis is a worldwide intracellular parasite disease of natural focus caused by Toxoplasma gondii,which has become one of the most important zoonoses seriously endangering the livestock industry development and socio-economic development in the *** this paper,advances in the epidemiological characteristics of toxoplasmosis,detection and diagnosis of toxoplasmosis,development of *** vaccines were summarized,which provided scientific basis for the control and treatment of *** infection.

关键词： Toxoplasmosis Epidemiology Detection methods diagnosis methods Advances

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