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A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing

引用

Chinese Chemical Letters 2024年第12期35卷 249-255页

作者： Haijun Shen Yi Qiao Chun Zhang Yane Ma Jialing Chen Yingying Cao Wenna Zheng Department of Preventive Medicine and Public Health Laboratory Science School of Medicine Jiangsu University

diabetic pressure ulcers(DPU) are non-healing due to vascular dysfunction and bacterial infection. Early intervention can delay ulcer progression, such as preventing the formation of full-thickness skin *** administration of deferoxamine(DFO) at wound sites has been shown to promote neovascularization and enhance wound healing. However, since DPU skin wounds are not full-thickness defects and DFO is hydrophilic, enhancing its transdermal delivery is crucial for effective treatment. Photothermal ablation of stratum corneum, generated by copper sulfide nanoparticles(Cu S NPs) under near-infrared(NIR) light irradiation, is a promising method to improve transdermal drug delivery. Meanwhile, Cu S NPs-induced photothermal therapy offers excellent antibacterial performance. In this study, DFO and Cu S NPs were incorporated into a matrix metalloproteinase(MMPs)-sensitive hydrogel. This hydrogel promotes cell adhesion and is degraded by cell-secreted MMPs, a process crucial for the controlled release of encapsulated DFO and Cu S NPs. Under NIR irradiation, the stratum corneum is disrupted, facilitating transdermal DFO delivery and simultaneously eliminating infected bacteria. As a result, the essential requirements for DPU treatment, “facilitating transdermal DFO delivery, promoting angiogenesis, and inhibiting bacterial infection”, were achieved simultaneously.

关键词： diabetic pressure ulcer Transdermal drug delivery Matrix metalloproteinase-sensitive hydrogel Antibacterial Angiogenesis

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