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浙江省生理科学会2006年学术年会

作者： LiyanCheng Zhejiang Academy of Medical Sciences , HangZhou

The aim of this study was to estimate the inhibitory effects of the flavonoid glycosides on the four pathways in diabetic complication, and find a new and effective extract of Chinese herbs for treatment of diabetic *** used vitro selecting model to investigate the inhibitory effects of the tested *** was shown, *** and Breviscapine have different degrees of inhibitory effects on aldose reductase, protein kinase C, advanced glycation end-products and malondialdehyde (MDA). It hinted that the two Chinese herbal extracts may prevent diabetic complication by inhibiting four pathways.2Silybin has different degrees of inhibitory effects on protein kinase C, advanced glycation end products and MDA. It hinted that Silybin may be effectively to prevencet diabetic complication.3. Puerarin has different degrees of inhibitory effects on aldose redactase and advanced glycation end-products.

关键词： flavonoid glycosides diabetic complication protein kinase C malondialdehyde advanced glycation end-products aldose reductase

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Efficacy of epalrestat plus α-lipoic acid combination therapy versus monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials

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Neural Regeneration Research 2018年第6期13卷 1087-1095页

作者： Ming Zhao Jia-Yi Chen Yu-Dong Chu Ya-Bin Zhu Lin Luo Shi-Zhong Bu Runliang Diabetes Laboratory Diabetes Research Center Ningbo University Department of Public Health Longsai Hospital Department of Nephrology Ningbo Medical Center Lihuili Eastern Hospital Medical School Ningbo University

OBJECTIVE： To evaluate the efficacy of α-lipoic acid（ALA） plus epalrestat combination therapy in the treatment of diabetic peripheral neuropathy（DPN）. DATA SOURCES： The electronic databases of Pub Med, Medline, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, the Wanfang Database and the Chinese Biomedical Database were used to retrieve relevant studies without language restrictions. The search was conducted from the inception of each database to 7 October 2016. The key terms were（diabetic peripheral neuropathy or diabetic neuropathy or DPN） AND（α-lipoic acid or lipoic acid or thioctic acid） AND epalrestat. DATA SELECTION： All of the eligible studies met the following inclusion criteria：（1） Randomized controlled trials that compared efficacy and safety of epalrestat plus ALA combination therapy versus epalrestat or ALA monotherapy in patients with DPN.（2） The minimum duration of treatment was 2 weeks.（3） The DPN patients were diagnosed using the World Health Organization standardized type 2 diabetes mellitus and DPN criteria.（4） Studies contained at least one measure that could reflect the efficacy of the drug and nerve conduction velocities. Studies in which the control group used epalrestat or ALA combined with other drugs were excluded. Statistical analyses were performed using STATA software for meta-analysis. OUTCOME MEASURES： The primary outcomes were the therapeutic efficacy, median motor nerve conduction velocity（MNCV）, median sensory nerve conduction velocity（SNCV）, peroneal MNCV and peroneal ***： Twenty studies with 1894 DPN patients were included, including 864 patients in the ALA plus epalrestat group, 473 in the ALA group and 557 in the epalrestat group. The efficacy of ALA plus epalrestat combination therapy was superior to ALA and epalrestat monotherapies（RR = 1.29, 95% CI： 1.21–1.38; RR = 1.43, 95% CI： 1.34–1.54, respectively）. ALA plus epalrestat combination therapy also significantly improved median MNCV（WMD = 5

关键词： nerve regeneration antioxidant aldose reductase inhibitor diabetic complication diabetes combination therapy nerve conduction velocity nerve electrophysiology peripheral nerve injury neural regeneration

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Antiglycating effects of citrus flavonoids and associated mechanisms

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Food Science and Human Wellness 2024年第5期13卷 2363-2372页

作者： Yunli Xiao Junfeng Shen Jianfeng Zhan Limin Guo Chi-Tang Ho Shiming Li College of Biology and Agricultural Resources Huanggang Normal UniversityHuanggang 438000China Institute of Agro-Products Storage and Processing Xinjiang Academy of Agricultural SciencesUrumqi 830091China Department of Food Science Rutgers UniversityNew Brunswick 08901USA

Glycation of proteins and DNA forms advanced glycation end products(AGEs)causing cell and tissue dysfunction and subsequent various chronic diseases,in particular,metabolic and age-related *** AGE inhibition includes scavengers of reactive carbonyl species(RCS)such as methylglyoxal(MG),glyoxalase-1 enhancers,Nrf2/ARE pathway activators,AGE/RAGE formation inhibitors and other antiglycatng *** flavonoids have demonstrated antioxidant and anti-inflammatory effects and are also found to be effective antiglycating ***,we reviewed the up to date progress of the antiglycation effects of citrus flavonoids and associated *** citrus flavonoids,hesperedin and its aglycone,hesperetin,inhibited glycation by scavenging MG forming mono-or di-flavonoid adducts with MG,enhanced the activity of glyoxase-1,activated Akt/Nrf2 signal pathway while inhibiting AGE/RAGE/NF-κB pathway,reduced the formation of Nε-(carboxylmethyl)lysine(CML)and pentosidine,inhibited aldol reductase activity and decreased the levels of *** antiglycating activity and mechanisms of other flavonoids was also summarized in this *** conclusion,citrus flavonoids possess effective antiglycating activity via different mechanisms,yet there are many challenging questions remaining to be studied in the near future such as in vivo testing and human study of citrus flavonoids for efficacy,effectiveness and adverse effects of citrus flavonoids as a functional food in managing high levels of AGEs and controlling AGE-induced chronic diseases,diabetic complications in particular.

关键词： Citrus flavonoids Hesperedin Advanced glycation end products Antiglycation diabetic complication

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Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)

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Burns & Trauma 2020年第1期8卷 217-268页

作者： Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu diabetic Foot Centre The Air Force Hospital From Eastern Theater of PLANanjing210002China Department of Burn and Plastic Surgery Affiliated Hospital of Jiangnan UniversityWuxi214062China Department of endocrinology the First Affiliated Hospital of Suzhou UniversitySuzhou215006China Department of endocrinology Jiangsu Province HospitalNanjing210029China Vascular Surgery Gulou HospitalNanjing210008China Department of orthopedics Nanjing First HospitalNanjing210006China Department of endocrinology The Second Affiliated Hospital of Suzhou UniversitySuzhou215004China Department of endocrinology Xuzhou Central HospitalXuzhou221009China Department of endocrinology Jiangsu Province Hospital on Traditional of Chinese and Western Medicine210028China Operating department Jiangsu Medical AssociationNanjing210008China diabetic Foot Centre The National University Hospital119077Singapore Department of Chronic Non-Communicable Diseases Chinese Center for Disease Control and PreventionBeijing102206China

In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been *** these complications,diabetic foot disease is one of the main causes of disability and death in diabetic *** to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary *** multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this *** 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and *** lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in *** paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of *** manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot.

关键词： diabetic foot disease diabetic peripheral neuropathy Peripheral arterial disease diabetic foot osteomyelitis diabetic foot infection diabetic complication Ankle-brachial index Transcutaneous oxygen pressure Recommendation Randomized controlled trials

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