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World Journal of Clinical Cases 2023年第31期11卷 7570-7582页

作者： Da Woon Lee Yong Seon Hwang Je Yeon Byeon Jun Hyuk Kim Hwan Jun Choi Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea

BACKGROUND Transcutaneous oxygen pressure(TcpO2)is a precise method for determining oxygen perfusion in wounded *** device uses either electrochemical or optical *** To evaluate the usefulness of TcpO2 measurements on free flaps(FFs)in diabetic foot ulcers(DFUs).METHODS TcpO2 was measured in 17 patients with DFUs who underwent anterolateral thigh(ALT)-FF surgery and compared with 30 patients with DFU without FF *** Significant differences were observed in the ankle-brachial index;duration of diabetes;and haemoglobin,creatinine,and C-reactive protein levels between the two ***2 values were similar between two groups except on postoperative days 30 and 60 when the values in the ALT-FF group remained50 *** Even if the flap is clinically stable,sympathectomy due to adventitia stripping during anastomosis and arteriovenous shunt progression due to diabetic polyneuropathy could lead to low TcpO2 values in the ALT-FF owing to its thick fat tissues,which is supported by the slow recovery of the sympathetic tone following ***,TcpO2 measurements in patients with DFU who underwent FF reconstruction may be less accurate than in those who did not.

关键词： Arteriovenous shunt Surgical diabetic neuropathies Free tissue flaps Sympathectomy Blood gas monitoring Transcutaneous diabetic angiopathies

Quantities of comorbidities affects physical, but not mental health related quality of life in type 1 diabetes with confirmed polyneuropathy

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World Journal of Diabetes 2019年第2期10卷 87-95页

作者： Anne-Marie L Wegeberg Theresa Meldgaard Sofie Hyldahl Poul Erik Jakobsen Asbjφrn M Drewes Birgitte Brock Christina Brock Mech-Sense Department of Gastroenterology and HepatologyAalborg University Hospital and Clinical InstituteAalborg UniversityAalborg 9000Denmark Steno Diabetes Center North Judland Region NordjyllandAalborg 9000Denmark Steno Diabetes Center Copenhagen Region HovedstadenGentofte 2820Denmark

BACKGROUND A large number of adults with long-term type 1 diabetes are affected by symmetrical peripheral *** complications increase socioeconomic expenses and diminish the individual quality of *** 36-Item Short Form Health Survey(SF-36)is a generic patient reported questionnaire,measuring mental and physical health related quality of *** hypothesized that diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and that clinical appearance may be associated with the *** To investigate if diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and if clinical appearance may be associated with the *** Forty-eight adults[age 50±9 years,10 females,disease duration 32(14-51)years]with verified diabetic symmetrical peripheral neuropathy and 21 healthy participants(age 51±6 years,6 females)underwent standardised nerve conduction testing and completed the SF-36 ***,disease duration,number of comorbidities,both diabetes related and nondiabetes related,vibration perception threshold,number of hypoglycaemic events,HbA1c and administration way of insulin was *** In comparison to healthy subjects,patients’mental composite score was not significantly diminished(51.9±8.9 vs 53.1±5.5,P=0.558),while the physical composite score was(46.3±11.7 vs 54.6±3.3,P=0.002).As expected,the overall physical health related symptoms in patients were associated to total number of comorbidities(P<0.0001),comorbidities relation to diabetes(P=0.0002)and HbA1c(P=0.005)as well as comorbidities not related to diabetes(P=0.0006).CONCLUSION The finding of this study emphasises the importance of focusing on quality of life in adults with diabetes and especially in those with multiple comorbidities as well as the possibility of HbA1c as a biomarker for severe complication.

关键词： Quality of life 36-Item Short Form Health Survey(SF-36) Diabetes mellitus,Type 1 diabetic neuropathies Comorbidity

Fuzzy expert system for diagnosing diabetic neuropathy

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World Journal of Diabetes 2017年第2期8卷 80-88页

作者： Meysam Rahmani Katigari Haleh Ayatollahi Mojtaba Malek Mehran Kamkar Haghighi Department of Health Information Management School of Health Management and Information Sciences IRAN University of Medical Sciences Division of Endocrinology and Metabolism Research Center of Firooz-gar Hospital IRAN University of Medical Sciences

AIM To design a fuzzy expert system to help detect and diagnose the severity of diabetic neuropathy. METHODS The research was completed in 2014 and consisted of two main phases. In the first phase, the diagnostic parameters were determined based on the literature review and by investigating specialists' perspectives(n= 8). In the second phase, 244 medical records related to the patients who were visited in an endocrinology and metabolism research centre during the first six months of 2014 and were primarily diagnosed with diabetic neuropathy, were used to test the sensitivity, specificity, and accuracy of the fuzzy expert *** The final diagnostic parameters included the duration of diabetes, the score of a symptom examination based on the Michigan questionnaire, the score of a sign examination based on the Michigan questionnaire, the glycolysis haemoglobin level, fasting blood sugar, blood creatinine, and albuminuria. The output variable was the severity of diabetic neuropathy which was shown as a number between zero and 10, had been divided into four categories: absence of the disease,(the degree of severity) mild, moderate, and severe. The interface of the system was designed by ***(Active Server Pages Network Enabled Technology) and the system function was tested in terms of sensitivity(true positive rate)(89%), specificity(true negative rate)(98%), and accuracy(a proportion of true results, both positive and negative)(93%).CONCLUSION The system designed in this study can help specialistsand general practitioners to diagnose the disease more quickly to improve the quality of care for patients.

关键词： Expert systems Fuzzy logic Artificial intelligence Diabetes mellitus Diabetes complications diabetic neuropathies

The Present Situation of TCM Treatment for Diabetes and its Researches

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Journal of Traditional Chinese Medicine 2003年第1期23卷 67-73页

作者：王琦王新中 Beijing University of Traditional Chinese Medicine Beijing 100029

Diabetes is a frequently encountered disease. There are now approximately 40 million diabetes patients in China1, most of them with diabetes II.

关键词： Acupuncture Therapy Phytotherapy Animals Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 diabetic Nephropathies diabetic neuropathies Drugs, Chinese Herbal Humans Insulin

ADVANCES IN TREATMENT OF diabetic NEUROPATHY BY TRADITIONAL CHINESE MEDICINE

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Journal of Traditional Chinese Medicine 1998年第2期18卷 146-152页

作者：衡先培张发荣 ChengduCollegeofTraditionalChineseMedicine.

diabetic neuropathy (DN) is the most commonly seen complication in diabetes mellitus (DM), and can occur in its early stage. With the prolongation of the course of the disease, the incidence of DN can reach 90％. The ... 详细信息

关键词： diabetic neuropathies Diagnosis, Differential Drugs, Chinese Herbal Humans Medicine, Chinese Traditional

Treatment of diabetic Neuropathy——Principles and Methods

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Journal of Traditional Chinese Medicine 2001年第3期21卷 163-167页

作者：梁晓春郭赛珊毛树章 TCM Department of Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing 100730

diabetic neuropathy (DN) is one of the common complications of diabetes mellitus (DM), its incidence can be as high as over 90%. The lesion can involve the sensory, motor and vegetative nerves. As a whole, the lesion can be divided into symmetric multiple neuropathy and asymmetric single neuropathy. Because the pathogenesis of the disease is not clear, no specific therapy is available so far. Besides control of blood sugar level, vitamin B, vasodilators and analgesics are often used in Western medicine for expectant treatment. Basic studies on chronic complications of DM show that aldose reductase and non-enzymatic glycosylation of protein are factors initiating the pathological changes, inhibitors against them have been tested in experimental studies and proved effective. Unfortunately, they are not used clinically due to severe side effects. Screening for herbal drugs to treat DN is still a popular trend in the TCM circle.

关键词： diabetic neuropathies Drug Therapy, Combination Drugs, Chinese Herbal Humans

CLINICAL OBSERVATION ON TREATMENT OF diabetic PERIPHERAL NEUROPATHY WITH REINFORCED TIANMA DUZHONG CAPSULE

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Journal of Traditional Chinese Medicine 1999年第3期19卷 182-184页

作者：李明瑞王湘 Beijing Hospital Beijing 100730

Reinforced Tianma Duzhong Capsule(RTDC, Reinforced Capsule of Gastrodia andEucommia强力天麻杜仲胶囊),an effectivepreparation for treating arthralgia-syndrome(such as arthralgia and limb numbness, etc.),was adopted to treat 36 cases of diabeticperipheral neuropathy. And enteric solubleaspirin was used in another group of 26 casesas control. The report is presented below.

关键词： Adult Aged Capsules Diabetes Mellitus, Type 2 diabetic neuropathies Drugs, Chinese Herbal Female Humans Male Middle Aged

A Clinical Study on Treatment of diabetic Peripheral Neuropathy with Tang Zhi Min Capsules

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Journal of Traditional Chinese Medicine 2000年第4期20卷 258-261页

作者：任慧雅 Baoding Municipal Hospital of Traditional Chinese Medicine Baoding 071000Hebei Province

Self-comparison before and after treatment, P<0.01　　△ Comparison between the 2 groups after treatment, P<0.

关键词： Adult Aged Blood Viscosity Capsules diabetic neuropathies Drugs, Chinese Herbal Female Humans Male Middle Aged

Observation on therapeutic efficacy of heat-sensitive moxibustion plus Western medicine for diabetic peripheral neuropathy

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Journal of Acupuncture and Tuina Science 2020年第6期18卷 452-457页

作者： Fang Xiu-juan Zheng Guo-xin Huangfu Ye-hui Yu Nian-tang Tonglu Hospital of Traditional Chinese Medicine Zhejiang ProvinceHangzhou 311500China

Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus Western medicine in treating patients with diabetic peripheral neuropathy(DPN).Methods:A total of 70 patients with DPN were divided into an observation group and a control group by sealed envelope method combined with the random number table method,with 35 cases in each *** control group was treated with routine medicine,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment in the control *** 2 courses of treatment,the scores of Toronto clinical scoring system(TCSS)and vibration perception threshold(VPT)in both groups were observed,and the clinical efficacy was ***:During treatment,3 cases dropped out in the control group and 4 cases in the observation *** treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The scores of TCSS and VPT in both groups decreased after treatment,and the intra-group comparison showed statistical significance(both P<0.05).The scores of TCSS and VPT in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion:Heat-sensitive moxibustion plus Western medicine can improve the symptoms in patients with DPN,and has a better curative effect than the Western medicine alone.

关键词： Moxibustion Therapy Moxa Stick Moxibustion Heat-sensitive Moxibustion Sensory Thresholds Diabetes MellitusType 2 diabetic neuropathies

Review of systematic reviews of acupuncture for diabetic peripheral neuropathy

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Journal of Acupuncture and Tuina Science 2021年第2期19卷 95-103页

作者： Fan Wei-jing Liang Shi-bing Han Qiang Huang Ren-yan Xu Feng Liu Guo-bin Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 201203China Center for Eviden ce-based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Objective:To review the systematic reviews of acupuncture for diabetic peripheral neuropathy(DPN)and to provide evidence for clinical ***:Published systematic reviews targeting acupuncture treatment of DPN were searched using computer through both Chinese and English databases till July 1,*** researchers screened the papers based on inclusion and exclusion criteria and conducted report quality evaluation,methodological quality assessment and evidence quality grading using the preferred reporting items for systematic reviews and meta-analyses(PRISMA),assessment of multiple systematic review 2(AMSTAR 2)and grading of recommendations assessment,development and evaluation(GRADE).Results:Ten systematic reviews were included,involving 11 outcome *** to PRISMA,6 items were sufficiently reported while 1 item was not;AMSTAR 2 appraised that all the included systematic reviews were of low quality in the methodological evaluation;according to GRADE,of the 30 clinical evidences,only 5 were graded moderate while the remained were graded low or extremely *** analysis showed that acupuncture can significantly improve DPN symptoms,accelerate the conduction velocities of sensory and motor nerves,and up-regulate the content of plasma nitric oxide(NO),while the adverse reaction rate was ***:Acupuncture can produce satisfactory clinical efficacy in treating DPN,but the existing problems,such as low-quality evidence,unitary outcome measures,poor methodological quality of systematic reviews and nonstandard reporting,need to be treated cautiously;meanwhile,more high-quality clinical trials are required to elevate the level of evidence.

关键词： Acupuncture Therapy Diabetes Mellitus,Type 2 diabetic neuropathies Peripheral Nervous System Diseases Systematic Review