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Effect of type 2 diabetic mellitus in the prognosis of acute-onchronic liver failure patients in China

World Journal of Gastroenterology 2021年第23期27卷 3372-3385页

作者： Rui-Min Lai Tian-Bin Chen Yu-Hai Hu Gui Wu Qi Zheng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Laboratory Medicine The First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Orthopedics The First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina

BACKGROUND Acute-on-chronic liver failure(ACLF)patients have a high short-term mortality rate,and the severity evaluation of ACLF is necessary for ***,it was meaningful to evaluate the association between type 2 diabetic mellitus(DM)and ACLF and further explore the feasibility of using DM as a prognostic indicator in ACLF *** association between type 2 DM and the prognosis of patients with severe liver disease remains *** To examine the effect of type 2 DM on the prognosis of patients with *** Clinical data from 222 ACLF patients were collected and *** patients were categorized into two groups depending on whether they had DM or not,and the clinical data of ACLF patients were measured within 48 h after *** of ACLF were documented during treatment,such as hepatic encephalopathy,hepatorenal syndrome,acute upper gastrointestinal hemorrhage,and spontaneous peritonitis(SBP).Values of laboratory parameters,complication rates,and hospital mortality rates were compared between two *** Among 222 ACLF patients,38 cases were categorized into DM groups,the mean age was 56.32 years and 73.68%were *** prognosis of ACLF patients was significantly correlated with DM in univariate[hazard ratio(HR)=2.4,95%confidence interval(CI)=1.5-3.7,P<0.001]and multivariable analysis(HR=3.17,95%CI=1.82-5.523,P<0.001).The incident of SBP(34.21%vs 13.59%,P=0.038)and other infections like lung,urinary,blood,and cholecyst(44.74%vs 28.26%,P=0.046)were higher in DM patients than non-DM *** addition,the ACLF patients with DM tended to have a high mortality rate(P<0.001).Cumulative survival time was also significantly shorter in the ACLF patients with DM than *** A significant association between DM and the prognosis of ACLF patients was found in *** ACLF patients with DM had higher incidence of hospital mortality and infection than those without DM.

关键词： Acute-on-chronic liver failure diabetic mellitus Prognosis Infection Type 2 diabetic mellitus

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Role of angiotensin receptor-neprilysin inhibitor in diabetic complications

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World Journal of Diabetes 2024年第5期15卷 867-875页

作者： Ying Liu Cun-Yu Lu Yi Zheng Yu-Min Zhang Ling-Ling Qian Ku-Lin Li Gary Tse Ru-Xing Wang Tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjin 300211China Department of Cardiology Xuzhou No.1 Peoples HospitalXuzhou 221005Jiangsu ProvinceChina Department of Cardiology Wuxi 9^(th)People’s Hospital Affiliated to Soochow UniversityWuxi 214062Jiangsu ProvinceChina Department of Cardiology Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina School of Nursing and Health Studies Metropolitan UniversityHong Kong 999077China Kent and Medway Medical School Kent CT27NTCanterburyUnited Kingdom

Diabetes mellitus is a prevalent disorder with multi-system manifestations,causing a significant burden in terms of disability and deaths ***-tensin receptor-neprilysin inhibitor(ARNI)belongs to a class of medications for treating heart failure,with the benefits of reducing hospitalization rates and *** review mainly focuses on the clinical and basic investigations related to ARNI and diabetic complications,discussing possible physiological and molecular mechanisms,with insights for future applications.

关键词： Angiotensin receptor-neprilysin inhibitor diabetic mellitus Complication

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Prevalence of Drug Resistant Uropathogenic Escherichia coli from Immunocompromised diabetic Patients Attending Selected Health Facilities in Benue State

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Advances in Microbiology 2024年第1期14卷 77-91页

作者： Isaac Ilesanma Adeoti Grace Mwuese Gberikon Innocent Okonkwo Ogbonna Tersagh Smart Ichor Department of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

Escherichia coli is the commonest bacterial uropathogen of UTIs, the commonest infections in immunocompromised diabetic patients. Better understanding of their main resistance mechanisms to commonly used antibacterial agents will help to reduce the burden of this infection. The prevalence of drug resistant uropathogenic Escherichia coli isolates from immunocompromised diabetic patients attending selected health facilities in Benue State was investigated. Two hundred and ninety-six midstream urine samples were collected for both study and control diabetic patients. Bacterial isolation was done using semi-quantitative method. Drug resistant Escherichia coli were identified as multidrug resistant (MDR), extensive drug resistant (XDR) and pan-drug resistant organisms (PDR). Statistical significance was considered at p E. coli isolates from the study and control subjects with overall prevalence of 20.9% and 8.4% respectively. The isolates were highly resistant to penicillin (ampicillin), monobactam (aztreonam), older quinolone (nalidixic acid) whereas the majority of them showed high susceptibility to aminoglycoside (streptomycin), cephalosporin (cefotaxime) and carbapenem (imipenem). None showed complete susceptibility to all the tested antibiotics. Twenty-five E. coli were identified in this MDR, eight, XDR while 5 were PDR. High numbers of drug resistant E. coli isolates were identified in the study group of which 25 were MDR, 8 XDR while 5 were PDR isolates. High prevalence of UTI and drug resistant isolates occur in diabetic patients with hyperglycemic condition.

关键词： Urinary Tract Infection Immunocompromised diabetic mellitus Antibiotic Resistance Escherichia coli

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Effects of autophagy inhibitor 3-methyladenine on a diabetic mice model

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1456-1464页

作者： Hai-Wen Ren Wen Yu Ya-Nan Wang Xin-Yi Zhang Shun-Qiong Song Shu-Yu Gong Ling-Yao Meng Chen Gan Ben-Ju Liu Quan Gong Health Science Center Yangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Clinical Laboratory Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Human Anatomy Medical School of Yangtze UniversityJingzhou 434023Hubei ProvinceChina Clinical Molecular Immunology Center Medical School of Yangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Immunology Medical School of Yangtze UniversityJingzhou 434023Hubei ProvinceChina

AIM:To investigate the role of autophagy inhibitor 3-methyladenine(3-MA)on a diabetic mice model(DM)and the potential ***:Male C57BL/6J mice were randomly divided into a normal control group(NC group)and an DM *** were induced by multiple low-dose intraperitoneal injection of streptozotocin(STZ)60 mg/kgd for 5 consecutive *** mice were randomly subdivided into untreated group(DM group),3-MA(10 mg/kgd by gavage)treated group(DM+3-MA group)and chloroquine(CQ;50 mg/kg by intraperitoneal injection)treated group(DM+CQ group).The fasting blood glucose(FBG)levels were recorded every *** the end of experiment,retinal samples were *** expression levels of pro-apoptotic proteins cleaved caspase-3,cleaved poly ADP-ribose polymerase 1(PARP1)and Bax,anti-apoptotic protein Bcl-2,fibrosisassociated proteins Fibronectin and type 1 collagenα1 chain(COL1A1),vascular endothelial growth factor(VEGF),inflammatory factors interleukin(IL)-1βand tumor necrosis factor(TNF)-α,as well as autophagy related proteins LC3,Beclin-1 and P62 were determined by Western *** oxidative stress indicators 8-hydroxydeoxyguanosine(8-OHdG)and malondialdehyde(MDA)were detected by commercial ***:Both 3-MA and CQ had shor t-term hypoglycemic effect on FBG and reduced the expression of VEGF and inflammatory factors IL-1βand TNF-αin DM mice.3-MA also significantly alleviated oxidative stress indicators 8-OHdG and MDA,decreased the expression of fibrosisrelated proteins Fibronectin and COL1A1,pro-apoptotic proteins cleaved caspase-3,cleaved PARP1,as well as the ratio of Bax/*** had no significant impact on the oxidative stress indicators,fibrosis,and apoptosis related *** results of Western blotting for autophagy related proteins showed that the ratio of LC3 II/LC3 I and the expression of Beclin-1 in the retina of DM mice were decreased by 3-MA treatment,and the expression of P62 was further increased by CQ ***:3-MA has anti-apop

关键词： diabetic mellitus 3-methyladenine autophagy fibrosis apoptosis mice

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Hyperglycemia induces protein nonenzymeatic glycosylation in brain neurons of diabetic rats at early stage

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Neural Regeneration Research 2007年第1期2卷 42-45页

作者： Jingsheng Hu Xueyi Ma Shuli Sheng Department of Endocrinology First Hospital Affiliated to General Hospital of Chinese PLA Bering 100037 China Beijing Laboratory for Brain Aging Xuanwu Hospital Affiliated to Capital Medical University Beijing 100053 China

BACKGROUND： Protein nonenzymatic glycosylation is supposed to be one of mechanisms for chronic complications development in diabetes mellitus, and therefore, might play an important role in the neuronal degeneration. OBJECTIVE： To study the protein nonenzymatic glycosylation in brain neurons of diabetic rats, and to analyze the pathway of neuronal degeneration at the early stage of hyperglymecia. DESIGN： Randomized controlled animal experiment. SETTING： Department of Endocrinology, First hospital Affiliated to General Hospital of Chinese PLA and Beijing Laboratory for Brain Aging, Xuanwu Hospital Affiliated to Capital Medical University. MATERIALS： Thirty-five male Wistar rats （grade Ⅱ ）, aged 3 months old, and 11 male purebred Kunming mice （grade Ⅲ） without special pathogen, aged 3 months old, were provided by the Animal Room of Capital Medical University. METHODS： This experiment was carried out in the Beijing Laboratory for Brain Aging, Xuanwu Hospital Affiliated to Capital Medical University in 1998. The rats in the diabetic model group were intraperitoneally injected into 10 g/L STZ according to 60 mg/kg to establish rat models of diabetes mellitus. The blood glucose and body mass of rats in each group were determined respectively at 1, 2 and 3 months after modeling. The antibodies of advanced glycosylation end products （AGEs） of bovine serum albumin （anti-BSA） were self-prepared： ①The antigen of AGEs-BSA was prepared.②Eleven male Kuming mice （grade Ⅱ） of 3 months old without special pathogen were selected to inoculate AGEs-BSA. ③The animals were immunized. ④Primary purification and detection of poly-antibodies of AGEs： the AGEs were performed immtmohistochemical examination at 1 month after diabetic modeling by ELISA method. MAIN OUTCOME MEASURES： ① Detection results of blood glucose and body mass of rats in two groups at different time points. ②Determination of polyclonal antibody titer of AGEs-BSA. ③Changes in immtmohistochemical image of AGEs in brain tissu

关键词： hyperglycemia diabetic mellitus immunohistochemistry

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Effects of coffee and caffeine on bladder dysfunction in streptozotocininduced diabetic rats

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Acta Pharmacologica Sinica 2006年第8期27卷 1037-1043页

作者： Chao-ran YI~(2,5) Zhong-qing WEI~2 Xiang-lei DENG~4 Ze-yu SUN~2 Xing-rong LI~4 Cheng-gong TIAN~3 ~2Department of Urology,~3Department of Endocrinology,the Affiliated Drum Tower Hospital,Nanjing University Medical School,Nanjing 210008,China ~4Department of Biochemisto,and Molecular Biology,Medieal College of Southeast University,Nanjing 210009,China Department of Urology the Affiliated Drum Tower Hospital Nanjing University Medical School Nanjing 210008 Chin

Aim:To explore the effects and mechanisms of caffeine and coffee on bladderdysfunction in streptozotocin-induced diabetic ***:Sprague-Dawleymale rats were divided randomly into 4 groups:control,diabetes mellitus(DM),DM with coffee treatment,and DM with caffeine *** diabetic rat wasinduced by intraperitoneal injection of streptozotocin(60 mg/kg).After 7 weeks oftreatment with coffee and caffeine,cystometrogram,contractile responses to elec-trical field stimulation(EFS)and acetylcholine(ACh),and cyclic AMP(cAMP)concentration of the bladder body and base were ***:The bladderweight,volume threshold for micturition and post-void residual volume(PVR)inthe diabetic rats were significantly higher compared to those in the control *** or caffeine treatment significantly reduced the bladder weight,bladdercapacity and PVR in the diabetic *** caused significant decreases in cAMPconcentration of the bladder and coffee and caffeine caused upregulation of cAMPcontent in the diabetic *** addition,coffee and caffeine tended to normal-ize the altered detrusor contractile responses to EFS and ACh in the diabetic ***:These results indicate that caffeine and coffee may have beneficialeffects on bladder dysfunction in the early stage of diabetes by increasing cAMPcontent in the lower urinary tract,recovering the micturition reflex and improvingthe detrusor contractility.

关键词： caffeine diabetic mellitus bladder urodynamics muscle contraction cyclic AMP

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Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis

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Asian Journal of Andrology 2018年第2期20卷 166-172页

作者： Kai Cui Zhe Tang Chuan-Chang Li Tao Wang Ke Rao Shao-Gang Wang Ji-Hong Liu Zhong Chen Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Previous studies have shown that oxidative stress and corporal fibrosis in penile tissues of rats were key pathological factors of erectile dysfunction induced by diabetic mellitus （DMED）. Lipoxin A4 （LXA4） was reported to inhibit oxidative stress and fibrosis diseases, while whether it could exert a protective role on erectile function was not clear. Type I diabetic mellitus （DM） was induced in thirty male lO-week-old Sprague-Dawley rats using streptozotocin. Ten weeks later, twenty-two rats with DMED confirmed by an apomorphine test were divided into two groups： the DMED group （n = 11） and the DMED ＋ LXA4 group （n = 11; LXA4 injection daily for 4 weeks）. In addition, another ten age-matched rats formed the Control group. We found that erectile function was significantly impaired in the DMED group compared with the Control group, but was improved in the DMED ＋ LXA4 group. Similarly, the over-activated oxidative stress and impaired endothelial function in the DMED group were both improved in the DMED ＋ LXA4 group. Moreover, the DMED group showed serious corporal fibrosis, which was also inhibited by the treatment of LXA4 in the DMED ＋ LXA4 group. Taken together, LXA4 could exert an inhibition role on oxidative stress and fibrosis to improve DMED effectively.

关键词： diabetic mellitus erectile dysfunction fibrosis oxidative stress

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Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats

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Neural Regeneration Research 2013年第12期8卷 1071-1080页

作者： Guiru Ren Jingjing Kong Ning Jia Xiuli Shang Department of Neurology the First Affiliated Hospital of China Medical University

Luteolin （3＇,4＇,5,7-tetrahydroxyflavone） has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment （given twice daily for 15 days） significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin- induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abiJities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway.

关键词： neural regeneration brain injury diabetic mellitus luteolin apoptosis learning and memory spatialrecognition memory nerve cells hippocampus anti-oxidation neuroregeneration

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Bile acids and microbes in metabolic disease

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World Journal of Gastroenterology 2022年第48期28卷 6846-6866页

作者： Dhiraj Kumar Sah Archana Arjunan Sun Young Park Young Do Jung Department of Biochemistry Chonnam National UniversityGwangju 501190South Korea Department of Internal Medicine Chonnam National UniversityGwangju 501190South Korea

Bile acids(BAs)serve as physiological detergents that enable the intestinal absorption and transportation of nutrients,lipids and *** are primarily produced by humans to catabolize cholesterol and play crucial roles in gut metabolism,microbiota habitat regulation and cell ***-activated nuclear receptors regulate the enterohepatic circulation of BAs which play a role in energy,lipid,glucose,and drug *** gut microbiota plays an essential role in the biotransformation of BAs and regulates BAs composition and ***,altered gut microbial and BAs activity can affect human metabolism and thus result in the alteration of metabolic pathways and the occurrence of metabolic diseases/syndromes,such as diabetes mellitus,obesity/hypercholesterolemia,and cardiovascular *** and their metabolites are used to treat altered gut microbiota and metabolic *** review explores the increasing body of evidence that links alterations of gut microbial activity and BAs with the pathogenesis of metabolic ***,we summarize existing research on gut microbes and BAs in relation to intracellular pathways pertinent to metabolic ***,we discuss how therapeutic interventions using BAs can facilitate microbiome functioning and ease metabolic diseases.

关键词： Bile acids Metabolic diseases Gut microbe diabetic mellitus Obesity Hypercholesterolemia

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Hypoglycemic and Hypolipidemic Effect of Bitter Kola (<i>Garcinia kola</i>) Seed Extract on Alloxan-Induced diabetic Albino Rats

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Journal of Biosciences and Medicines 2020年第6期8卷 127-134页

作者： Ibanga I. Etim Nkereuwem S. Etukudoh Olaniru B. Olumide Obeta M. Uchejeso Nwapi L. Lucy Fiyaktu Y. Bwotle Department of Chemical Pathology Federal School of Medical Laboratory Science Jos Nigeria Department of Haematology Federal School of Medical Laboratory Science Jos Nigeria Department of Chemical Pathology Jos University Teaching Hospital Jos Nigeria

The treatment and management of diabetes mellitus has been a challenge to achieve a total cure using conventional drugs. Hypoglycemic and hypolipidemic effects of bitter kola (Garcinia kola) seed extract on alloxan-induced diabetic rats were studied as a local product. Albino rats weighing about 200 g were investigated in groups using 200 - 800 mg/kg weight of bitter kola seed extract and the sample examined for glucose and lipid profiles using enzymatic methods and statistically analyzed using statistical package for social science (SPSS) windows, version 20.0. The results were expressed as the Mean ± SD. The results for the serum glucose and low density lipoprotein cholesterols (LDL-C) concentrations of untreated diabetic rats, and treated rats showed a significant (P diabetic rats, and treated rats showed increase in concentration which was not significant (P > 0.05) from 200 - 800 mg/kg weight when compared with the controls. High density lipoproteins (HDL-C) concentrations for untreated diabetic rats, and treated rats showed increase in concentration which was significant (P Garcinia kola) seed extract.

关键词： Hypoglycemia Hypolipidemia Bitter Kola diabetic mellitus

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