检索结果-南通市图书馆

Usage of topical insulin for the treatment of diabetic keratopathy,including corneal epithelial defects

World Journal of Diabetes 2023年第6期14卷 930-938页

作者： Ching Yee Leong Ainal Adlin Naffi Wan Haslina Wan Abdul Halim Mae-Lynn Catherine Bastion Department of Ophthalmology Universiti Kebangsaan Malaysia Medical CentreKuala Lumpur 56000Wilayah PersekutuanMalaysia

BACKGROUND diabetic keratopathy(DK)occurs in 46%-64%of patients with diabetes and requires serious *** patients with diabetes,the healing of corneal epithelial defects or ulcers takes longer than in patients without *** is an effective factor in wound *** ability of systemic insulin to rapidly heal burn wounds has been reported for nearly a century,but only a few studies have been performed on the effects of topical insulin(TI)on the *** with TI is effective in treating *** To review clinical and experimental animal studies providing evidence for the efficacy of TI to heal corneal *** National and international databases,including PubMed and Scopus,were searched using relevant keywords,and additional manual searches were conducted to assess the effectiveness of TI application on corneal wound *** articles published from January 1,2000 to December 1,2022 were *** relevancy of the identified citations was checked against predetermined eligibility standards,and relevant articles were extracted and *** A total of eight articles were found relevant to be discussed in this review,including four animal studies and four clinical *** to the studies conducted,TI is effective for corneal re-epithelialization in patients with diabetes based on corneal wound size and healing *** Available animal and clinical studies have shown that TI promotes corneal wound healing by several *** use of TI was not associated with adverse effects in any of the published *** studies are needed to enhance our knowledge and understanding of TI in the healing of DK.

关键词： Diabetes mellitus diabetic keratopathy Topical insulin Healing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corneal alteration and pathogenesis in diabetes mellitus

引用

International Journal of Ophthalmology(English edition) 2019年第12期12卷 1939-1950页

作者： Han Zhao Yan He Yue-Rong Ren Bai-Hua Chen Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center o f Ophthalmic Disease Changsha 410011Hunan ProvinceChina

The incidence of diabetes mellitus(DM) and its complications have increased considerably worldwide. diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumulating evidence that diabetic keratopathy is correlated with the hyperglycemic state. Different corneal components may produce different alterations under hyperglycemia. In addition, diabetic nerve alteration may become a novel biomarker of earlystage DM. Abnormalities of the corneal nerve plexus have been associated with diabetic inflammatory states. There is rapidly growing evidence based on investigations of diabetic corneal nerves through in vivo confocal microscopy. Understanding the molecular pathogenesis caused by hyperglycemia may assist in the identification of novel biomarkers, as well as therapeutic targets for early treatment. This review mainly summarizes recent findings on corneal alteration and pathogenesis in DM.

关键词： diabetes mellitus diabetic keratopathy diabetic neuropathy in vivo confocal microscopy advanced glycation end products

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：