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Intralesion and Curaderm<sup>BEC5</sup>Topical Combination Therapies of solasodine Rhamnosyl Glycosides Derived from the Eggplant or devil’s Apple Result in Rapid Removal of Large skin Cancers. Methods of Treatment Compared

引用

International Journal of Clinical Medicine 2012年第2期3卷 115-124页

作者： Bill E. Cham “Villa Del Aripo” Sheldon Australia.

solasodine rhamnosyl glycosides (sRGs) are chemotherapeutic agents for the treatment of cancer. sRGs in a cream formulation, CuradermBEC5, is very effective for the treatment of nonmelanoma skin cancers with excellent cosmetic end results. Intralesion injection of sRGs successfully dispose of very large tumours in animals without any clinical adverse effects. The mode of action of sRGs is by apoptosis. In this study, it is shown that small to large basal cell carcinomas are effectively treated only with topical application of CuradermBEC5. Here it is reported for the first time that combination of intralesion sRG injection and topical application with CuradermBEC5 in humans reduces the treatment time period by more than half when compared with topical application as the sole treatment regime. Two intralesion injections of very low doses of sRGs rapidly and effectively remove a large melanoma on a horse. If rapid removal of large troublesome skin cancers is required then this can be achieved by intralesion and topical treatments. Intralesion or combination therapy with sRGs may have some applications for melanomas in situ such as lentigo maligna.

关键词： Cancer devil’s Apple Eggplant Curaderm solamargine Apoptosis

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solasodine Glycosides from the Eggplant in a Topical Cream Psorend<sup>BEC</sup>Are Effective against Psoriasis

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International Journal of Clinical Medicine 2019年第3期10卷 174-182页

作者： Tania R. Chase Kai E. Cham Bill E. Cham Australasian Medical Research Port Vila Republic of Vanuatu

Background: Psoriasis is a chronic disease that can have significant effects on quality of life. Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can treat psoriasis. Case Presentation: We report a case of a 54-year-old French-Vietnamese male who presented with diagnosed erythematous scaly annular recalcitrant psoriasis scattered throughout his body. Method: After failing conventional treatment regimens for over 10 years the patient received a trial with a topical cream formulation PsorendBEC, containing solasodine glycosides, for his psoriasis. Result: Topical applications of PsorendBEC twice daily resulted in complete resolution of cutaneous lesions after 4 weeks of treatment with no recurrence post 1 year after therapy. Conclusion: Topical PsorendBEC therapy rapidly removes recalcitrant psoriasis with no apparent side effects.

关键词： Psoriasis BEC solasodine Glycosides PsorendBEC Eggplant devil’s Apple Black Nightshade

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