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Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks

World Journal of Stem Cells 2020年第2期12卷 110-122页

作者： Gabriela S Kronemberger Renata Akemi Morais Matsui Guilherme de Almeida Santos de Castro e Miranda JoséMauro Granjeiro Leandra Santos Baptista Bioengineering Directory of Metrology Applied to Life SciencesNational Institute of MetrologyQuality and Technology(INMETRO)Duque de CaxiasRJ 25250-020Brazil Post-graduate Program in Translational Biomedicine(Biotrans) UnigranrioCampus IDuque de CaxiasRJ 25250-020Brazil Post-graduate Program in Biotechnology National Institute of MetrologyQuality and Technology(INMETRO)Duque de CaxiasRJ 25250-020Brazil Federal University of Rio de Janeiro(UFRJ) Campus Duque de CaxiasDuque de CaxiasRJ 25250-020Brazil Laboratory of Clinical Research in Odontology Fluminense Federal University(UFF)Niterói 25255-030 Brazil Multidisciplinary Center for Biological Research(Numpex-Bio) Federal University of Rio de Janeiro(UFRJ)Campus Duque de CaxiasDuque de CaxiasRJ 25245-390Brazil

Scaffold-free techniques in the developmental tissue engineering area are designed to mimic in vivo embryonic processes with the aim of biofabricating,in vitro,tissues with more authentic *** clusters called spheroids are the basis for scaffold-free tissue *** this review,we explore the use of spheroids from adult mesenchymal stem/stromal cells as a model in the developmental engineering area in order to mimic the developmental stages of cartilage and bone *** from adult mesenchymal stromal/stem cells lineages recapitulate crucial events in bone and cartilage formation during embryogenesis,and are capable of spontaneously fusing to other spheroids,making them ideal building blocks for bone and cartilage tissue ***,we discuss data from ours and other labs on the use of adipose stromal/stem cell spheroids in chondrogenesis and osteogenesis in ***,recent studies support the notion that spheroids are ideal"building blocks"for tissue engineering by“bottom-up”approaches,which are based on tissue assembly by advanced techniques such as three-dimensional *** studies on the cellular and molecular mechanisms that orchestrate spheroid fusion are now crucial to support continued development of bottom-up tissue engineering approaches such as three-dimensional bioprinting.

关键词： Adipose stromal/stem cells Spheroids Building-blocks Bottom-up developmental tissue engineering Cartilage and bone

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