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developmental expression of cyclin h and cdk7 in zebrafish:the essential role of cyclin h during early embryo development

Developmental Expression of Cyclin H and Cdk7 in Zebrafish:t...

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中国遗传学会“发育、遗传和疾病”研讨会

作者： Qingyun Liu~1 Zhili Wu~1 Wenjian Lv~1 Yuanchang Yan~(1,2) Yiping Li~1 1.Lab of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Science,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,320 Yue Yang Road,Shanghai 200031,China 2.Model Organism Division,E-institutes of Shanghai University,Shanghai 200025,China

cyclin-dependent kinase 7(cdk7)is the catalytic subunit of the metazoan cdk-activating kinase (CAK).Activation of cdk7 requires its association with a regulatory subunit,cyclin *** the cdk7/cyclin h complex has been implicated in the regulation of RNA polymerase in several species,the precise function of their orthologs in zebrafish has not been fully *** this study,we isolated from zebrafish blastula embryos two cDNAs encoding the orthologs of human cyclin h and cdk7,and examined the role of cdk7/cyclin h in zebrafish *** analysis showed that the zebrafish cyclin h and cdk7 cDNAs encode proteins with 65% and 86% identity to the respective human orthologs. RT-PCR and whole-mount in situ hybridization analyses of their expression in unfertilized eggs,embryos and organs of adult fish suggested that cyclin tt and cdk7 messages are maternally *** data also showed that their transcripts were detected throughout *** of cyclin h transcripts was found to be ubiquitous during early stages of development and become restricted to the anterior neural tube,brain,eyes,procreate tissues,liver and heart by 5 days *** of a dominant-negative form of cyclin h delayed the onset of zygotic transcription in the early embryo, resulting in apoptosis at 5 hours post-fertilization and leading to sever defects in tissues normally exhibiting high levels of cyclin h *** results implicate cyclin h in the regulation of the transcriptional machinery during midblastula transition and suggest that it is an essential gene in early zebrafish larval development.

关键词： cyclin developmental expression of cyclin h and cdk7 in zebrafish:the essential role of cyclin h during early embryo development

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