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Current protocols and outcomes of ABO-incompatible kidney transplantation

World Journal of Transplantation 2020年第7期10卷 191-205页

作者： Maurizio Salvadori Aris Tsalouchos Department of Transplantation Renal Unit Careggi University HospitalFlorence 50139Italy Nephrology and Dialysis Unit Saints Cosmas and Damian HospitalPescia 51017Italy

One of the principal obstacles in transplantation from living donors is that approximately 30%are immunologically incompatible because of the presence in the recipient of antibodies directed against the human leukocyte antigen system of the donor or because of the incompatibility of the ABO *** aim of this review is to describe the more recent data from the literature on the different protocols used and the clinical outcomes of ABO-incompatible kidney *** different strategies are used to overcome these barriers:desensitization of the recipient to remove the antibodies and to prevent their rebound after transplantation and the exchange of organs between two or more *** largest part of this review is dedicated to describing the techniques of *** if the first reports of successful renal transplantation between ABO-incompatible pairs have been published by 1980,the number of ABO-incompatible transplants increased substantially in this century because of our improved knowledge of the immune system and the availability of new *** has substantially replaced *** technique of apheresis has improved and more recently a tailored desensitization proved to be the more efficient strategy avoiding an excess of immunosuppression with the related side *** reports document outcomes for such transplantation similar to the outcomes of standard transplantation.

关键词： ABO-incompatible transplants desensitization strategies Immunological aspects B cell depletion Immunomodulation Apheresis techniques Kidney paired donation

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