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Improving Energy Metabolism of deproteinized Extract of Calf Blood Through Regulation of Hmgcs2y Cptla, Angptl4, Cyp8bl, and Ehhadh Genes in Mice

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Chemical Research in Chinese Universities 2019年第3期35卷 427-433页

作者： ZHOU Tong XU Guangyu SUN Luyao YU Zhenxiang WANG Guixia Department of Endocrinology and Metabolism the First Hospital of Jilin UniversityChangchun 130021P.R.China College of Pharmacy Beihua UniversityJilin 132013P.R.China Department of Infectious Diseases the First Hospital ofJilin UniversityChangchun 130021P.R.China Department cf Respiration the First Hospital of Jilin University y Changchun 130021P.R.China

Herein, we described the physicochemical properties of deproteinized extract of calf blood(DECB) and established a hypoxia model treated with or without DECB to detect the sugar, lactic acid, protein, and ATP contents of mice and then identified and analyzed the differentially expressed genes between two groups using mRNA expression chip. According to the results of the airtight hypoxia experiment, mice in the model+DECB group had a signifi? cantly prolonged time of hypoxia tolerance compared with the model group. The biochemical test indicated that DECB could significantly increase the level of sugar, ATP and proteins and reduce the amount of lactic acid in mice. It also revealed that Hmgcs2, Cptla, Angptl4, Cyp8b], and Ehhadh genes were involved in mice energy metabolism, and were closely associated witli metabolic signaling pathway. These results suggest that DECB might be a potential drug to treat metabolic diseases. Among the genes with differential expression under hypoxia, Angptl4, Cyp8bl, and Ehhadh were critical factors for sugar metabolism. Hmgcs2 provided energy directly, and Cptla regulated cellular inflammatory responses, promoting energy metabolism.

关键词： deproteinized extract of calf blood Energy metabolism mRNA chip

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Clinical effect of deproteinized calfblood extract eye gel for corneal epithelial defect

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Discussion of Clinical Cases 2018年第2期5卷 7-10页

作者： Chungang Zhang Mingxia Wei The Forth Hospital of Baotou BaotouInner MongoliaChina Baogang Hospital BaotouInner MongoliaChina

Objective: To observe the clinical effect of 20% deproteinized calfblood extract eye gel on the treatment of mechanical injury to corneal epithelium. Methods: 120 cases of patients with corneal epithelial defect caused by mechanical injury were selected and randomly divided into observation group (60 eyes, deproteinized calfblood extract eye gel in use) and control group (0.3% ofloxacin eye drops in use). Both two groups of patients were given eye gel or eye drops 4 times per day. Moreover, the two groups of eye symptoms and corneal epithelial healing were observed on the 3rd day and the 7th day after drug usage respectively. Results: The effective rates of 20% deproteinized calfblood extract eye gel on the treatment of mechanical corneal epithelial defect on the 3rd day and the 7th day were 78.33% and 93.33% respectively. Meanwhile, the effective rates of 0.3% ofloxacin eye drops were 55.00% and 71.67%. The difference in the comparison of the effective rate between two groups was of statistical significance (p deproteinized calfblood extract eye gel can significantly promote the healing of corneal epithelium in a short time, and it is worthy to be widely applied clinically.

关键词： deproteinized calfblood extract eye gel Corneal epitheliums Mechanical injury

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