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A secondary bile acid from microbiota metabolism attenuates ileitis and bile acid reduction in subclinical necrotic enteritis in chickens

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Journal of Animal Science and Biotechnology 2020年第3期11卷 767-776页

作者： Mohit Bansal Ying Fu Bilal Alrubaye Mussie Abraha Ayidh Almansour Anamika Gupta Rohana Liyanage Hong Wang Billy Hargis Xiaolun Sun Center of Excellence for Poultry Science University of Arkansas1260 W Maple St.O409FayettevilleAR 72701USA CEMB University of ArkansasFayettevilleAR 72701USA Department of Chemistry University of ArkansasFayettevilleAR 72701USA.

Background:Clostridium perfringens-induced chicken necrotic enteritis(NE)is responsible for substantial economic losses worldwide ***,as a result of antibiotic growth promoter prohibition,the prevalence of NE in chickens has *** study was aimed to reduce NE through titrating dietary deoxycholic acid(DCA)as an effective antimicrobial *** and methods:Day-old broiler chicks were assigned to six groups and fed diets supplemented with 0(basal diet),0.8,1.0 and 1.5 g/kg(on top of basal diet)*** birds were challenged with Eimeria maxima(20,000 oocysts/bird)at d 18 and ***(109 CFU/bird per day)at d 23,24,and 25 to induce *** birds were sacrificed at d 26 when ileal tissue and digesta were collected for analyzing histopathology,mRNA accumulation and *** colonization by real-time PCR,targeted metabolomics of bile acids,fluorescence in situ hybridization(FISH),or terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)***:At the cellular level,birds infected with *** and *** developed subclinical NE and showed shortening villi,crypt hyperplasia and immune cell infiltration in *** DCA alleviated the NE-induced ileal inflammation in a dose-dependent manner compared to NE control *** with the increased histopathological scores,subclinical NE birds suffered body weight gain reduction compared to the uninfected birds,an effect attenuated with increased doses of dietary *** the molecular level,the highest dose of DCA at 1.5 g/kg reduced *** luminal colonization compared to NE birds using PCR and ***,the dietary DCA reduced subclinical NE-induced intestinal inflammatory gene expression and cell apoptosis using PCR and TUNEL *** further examining ileal bile acid pool through targeted metabolomics,subclinical NE reduced the total bile acid level in ileal digesta compared to uninfected ***,dietary DCA increased total

关键词： Bile acid Chicken Clostridium perfringens deoxycholic acid Intestinal inflammation Necrotic enteritis

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