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Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant

Regenerative Biomaterials 2024年第1期3卷 82-93页

作者： Jing Zhang Jie Wang Jiayi You Xuan Qin Huimin Chen Xiantong Hu Yantao Zhao Yang Xia Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210029PR China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjingJiangsu 210029PR China Department of Restorative dental Sciences Faculty of DentistryThe University of Hong KongHong Kong SARPR China Senior Department of Orthopedics The Fourth Medical Center of PLA General HospitalBeijing100048PR China Beijing Engineering Research Center of Orthopedics implants Beijing 100048PR China State Key Laboratory of Military Stomatology Xi'an 710032PR China

The removal of a failed implant with high torque causes significant damage to the surrounding tissue,compromising bone regeneration and subsequent osseointegration in the defect area.Here,we report a case of carrier screw fracture followed by immediate implant removal,bone grafting and delayed reimplantation.A dental implant with a fractured central carrier screw was removed using the bur-forceps technique.The resulting three-wall bone defect was filled with granular surface demineralized freeze-dried bone allograft(SD-FDBA).Cone-beam computerized tomography was performed at 1week,6months and 15months postoperatively and standardized for quantitative evaluation.The alveolar bone width and height at 15months post-surgery were about 91%of the original values,with a slightly lower bone density,calculated using the gray value ratio.The graft site was reopened and was found to be completely healed with dense and vascularized bone along with some residual bone graft.Reimplantation followed by restoration was performed 8months later.The quality of regenerated bone following SD-FDBA grafting was adequate for osseointegration and longterm implant success.The excellent osteogenic properties of SD-FDBA are attributed to its human origin,cortical bone-like structure,partly demineralized surfaces and bone morphogenetic protein-2-containing nature.Further investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： dental implant implant failure allogeneic bone bone regeneration reimplantation

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Oblique Cutting Based Mechanical Model for Insertion Torque of dental implant

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 92-105页

作者： Luli Li Song Zhang Quhao Li Cuirong Bian Airong Zhang School of Mechanical Engineering Shandong UniversityJinan 250061China Key Laboratory of High-efficiency and Clean Mechanical Manufacture of Ministry of Education JinanChina Department of Prosthodontics Qilu Hospital of Shandong UniversityJinan 250012China.

The insertion torque of a dental implant is an important indicator for the primary stability of dental implants.Thus,the preoperative prediction for the insertion torque is crucial to improve the success rate of implantation surgery.In this present research,an alternative method for prediction of implant torque was proposed.First,the mechanical model for the insertion torque was established based on an oblique cutting process.In the proposed mechanical model,three factors,including bone quality,implant geometry and surgical methods were considered in terms of bone-quality coefficients,chip load and insertion speeds,respectively.Then,the defined bone-quality coefficients for cancellous bone with the computed tomography(CT)value of 235–245,345–355 and 415–425 Hu were obtained by a series of insertion experiments of IS and ITI implants.Finally,the insertion experiments of DIO implants were carried out to verify the accuracy of developed model.The predicted insertion torques calculated by the mechanical model were compared with those acquired by insertion experiments,with good agreement,the relative error being less than 15%.This method allows the insertion torque for different implant types to be quickly established and enhances prediction accuracy by considering the effects of implants’geometries and surgical methods.

关键词： Insertion torque Mechanical model Oblique cutting dental implant

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dental implant treatment for renal failure patients on dialysis:a clinical guideline

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International Journal of Oral Science 2017年第3期9卷 125-132页

作者： Yuan,Quan Xiong,Qiu-Chan Gupta,Megha Maria Lopez-Pintor,Rosa Chen,Xiao-Lei Seriwatanachai,Dutmanee Densmore,Michael Man,Yi Gong,Ping state key laboratory of oral diseases national clinical research center for oral diseaseswest china hospital of stomatologysichuan universityChengduChina department of oral implantology west china hospital of stomatologysichuan universityChengduChina department of preventive dental sciences division of pedodonticscollege of dentistryal-showajra academic campusjazan universityGizanKingdom of Saudi Arabia department of oral medicine and surgery school of dentistrycomplutense universityMadridSpain department of nephrology west china hospitalsichuan universityChengduChina department of oral biology faculty of dentistrymahidol universityBangkokThailand department of oral medicine infectionand immunityharvard school of dental medicineBostonUSA

Chronic kidney disease （CKD） is a worldwide public health problem that is growing in prevalence and is associated with severe complications. During the progression of the disease, a majority of CKD patients suffer oral complications. dental implants are currently the most reliable and successful treatment for missing teeth. However, due to complications of CKD such as infections, bone lesions, bleeding risks, and altered drug metabolism, dental implant treatment for renal failure patients on dialysis is more challenging. In this review, we have summarized the characteristics of CKD and previous publications regarding dental treatments for renal failure patients. In addition, we discuss our recent research results and clinical experience in order to provide dental implant practitioners with a clinical guideline for dental implant treatment for renal failure patients undergoing hemodialysis.

关键词： chronic kidney disease dental implant hemodialysis osseointegration renal failure

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A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation

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Chinese Chemical Letters 2024年第2期35卷 386-395页

作者： Liang Cheng Bingshuai Zhou Manlin Qi Xiaolin Sun Shujun Dong Yue Sun Biao Dong Lin Wang Yingwei Yang Department of Oral implantology Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering School and Hospital of StomatologyJilin UniversityChangchun 130021China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130021China College of Chemistry Jilin UniversityChangchun 130012China

Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri‑implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the large penetration depth in tissue.However,the complexity of hypoxia microenvironments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical application.Due to the long lifespan and transmission distance of therapeutic gas molecules,we design a multi-functional gas generator that combines aPDT as well as O_(2) and CO gas release function,which can solve the problem of hypoxia(O_(2))in PDT and the problem of inflammation regulation(CO)in the distal part of peri‑implant inflammation under near-infrared(NIR)irradiation.In the composite nanoplatform that spin-coated on the surface of titanium implants,up-conversion nanoparticles(UCNPs)were involved in converting the NIR to visible,which further excites the partially oxidized stannic sulfide(SnS_(2)),realizing the therapeutic gas release.Indocyanine green(ICG)was further integrated to enhance the aPDT performance(Ti-U@SnS_(2)/I).Therefore,reactive oxygen species(ROS),CO,and O_(2) can be controllably administered via a composite nano-platform mediated by a single NIR light(808 nm).This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions,such as relieving the anoxic microenvironment and reaching deep infection sites,providing a viable antibiotic-free technique to combat peri‑implantitis.

关键词： Photodynamic therapy Biomaterials dental implant Reactive oxygen species Carbon monoxide Hybrid nanoplatform

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Bone block from lateral window-correcting vertical and horizontal bone deficiency in maxilla posterior site:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2109-2115页

作者： Yu-Lan Wang Wen-Jun Shao Min Wang State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079Hubei ProvinceChina Department of Oral implantology School and Hospital of StomatologyWuhan UniversityWuhan 430079Hubei ProvinceChina

BACKGROUND Lateral window approach for sinus floor lift is commonly used for vertical bone augmentation in cases when the residual bone height is less than 5 mm.However,managing cases becomes more challenging when a maxillary sinus pseudocyst is present or when there is insufficient bone width.In this case,we utilized the bone window prepared during the lateral window sinus lift as a shell for horizontal bone augmentation.This allowed for simultaneous horizontal and vertical bone augmentation immediately after the removal of the maxillary sinus pseudocyst.CASE SUMMARY A 28-year-old female presented to our clinic with the chief complaint of missing upper left posterior teeth.Intraoral examination showed a horizontal deficiency of the alveolar ridge contour.The height of the alveolar bone was approximately 3.6 mm on cone beam computed tomography(CBCT).And a typical well-defined'dome-shaped'lesion in maxillary sinus was observed on CBCT imaging.The lateral bony window was prepared using a piezo-ultrasonic device,then the bony window was fixed to the buccal side of the 26 alveolar ridge using a titanium screw with a length of 10 mm and a diameter of 1.5 mm.The space between the bony window and the alveolar ridge was filled with Bio-Oss,covered with a Bio-Gide collagen membrane,and subsequently sutured.Nine months later,the patient’s bone width increased from 4.8 to 10.5 mm,and the bone height increased from 3.6 to 15.6 mm.Subsequently,a Straumann^(■)4.1 mm×10 mm implant was placed.The final all-ceramic crown restoration was completed four months later,and both clinical and radiographic examinations showed that the implant was successful,and the patient was satisfied with the results.CONCLUSION The bone block harvested from the lateral window sinus lift can be used for simultaneous horizontal bone augmentation acting as a shell for good two-dimensional bone augmentation.

关键词： Sinus lift Lateral window dental implant Horizontal bone augmentation Case report

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Micromotions and combined damages at the dental implant/bone interface

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International Journal of Oral Science 2012年第4期4卷 182-188页

作者： Shan-Shan Gao Ya-Rong Zhang Zhuo-Li Zhu Hai-Yang Yu State Key Laboratory of Oral Diseases Sichuan University

Micromotion and fretting damages at the dental implant/bone interface are neglected for the limitation of check methods, but it is particularly important for the initial success of osseointegration and the life time of dental implant. This review article describes the scientific documentation of micromotion and fretting damages on the dental implant/bone interface. The fretting amplitude is less than 30 l^m in vitroand the damage in the interface is acceptable. While in vivo, the micromotion＇s effect is the combination of damage in tissue level and the real biological reaction.

关键词： dental implant fretting damage micromotion

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Binary titanium alloys as dental implant materials—a review

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Regenerative Biomaterials 2017年第5期4卷 315-323页

作者： Xiaotian Liu Shuyang Chen James K.H.Tsoi Jukka Pekka Matinlinna Department of Orthodontics Tianjin Stomatological Hospital of Nankai UniversityTianjinP.R.China dental Materials Science Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARP.R.China Department of Prosthodontics Tianjin Stomatological Hospital of Nankai UniversityTianjinP.R.China

Titanium(Ti)has been used for long in dentistry and medicine for implant purpose.During the years,not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were used.The aim of this review is to describe and compare the current literature on binary Ti alloys,including Ti-Zr,Ti-In,Ti-Ag,Ti-Cu,Ti-Au,Ti-Pd,Ti-Nb,Ti-Mn,Ti-Mo,Ti-Cr,Ti-Co,Ti-Sn,Ti-Ge and Ti-Ga,in particular to mechanical,chemical and biological parameters related to implant application.Literature was searched using the PubMed and Web of Science databases,as well as google without limiting the year,but with principle key terms such as‘Ti alloy’,‘binary Ti’,‘Ti-X’(with X is the alloy element),‘dental implant’and‘medical implant’.Only laboratory studies that intentionally for implant or biomedical applications were included.According to available literatures,we might conclude that most of the binary Ti alloys with alloyingimplant materials,due to good mechanical performance without compromising the biocompatibility and biological behaviour compare to cp-Ti.

关键词： binary Ti Ti alloy dental implant biocompatibility

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Osteoblast integration of dental implant materials after challenge by sub-gingival pathogens: a co-culture study in vitro

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International Journal of Oral Science 2015年第4期7卷 250-258页

作者： Bingran Zhao Henny C van der Mei Minie Rustema-Abbing Henk J Busscher Yijin Ren Department of Orthodontics University of Groningen and University Medical Center Groningen Department of Biomedical Engineering University of Groningen and University Medical Center Groningen

Sub-gingival anaerobic pathogens can colonize an implant surface to compromise osseointegration of dental implants once the soft tissue seal around the neck of an implant is broken. In vitro evaluations of implant materials are usually done in monoculture studies involving either tissue integration or bacterial colonization. Co-culture models, in which tissue cells and bacteria battle simultaneously for estate on an implant surface, have been demonstrated to provide a better in vitro mimic of the clinical situation. Here we aim to compare the surface coverage by U2OS osteoblasts cells prior to and after challenge by two anaerobic sub-gingival pathogens in a co-culture model on differently modified titanium （Ti）, titanium-zirconium （TiZr） alloys and zirconia surfaces. Monoculture studies with either U2OS osteoblasts or bacteria were also carried out and indicated significant differences in biofilm formation between the implant materials, but interactions with U2OS osteoblasts were favourable on all materials. Adhering U2OS osteoblasts cells, however, were significantly more displaced from differently modified Ti surfaces by challenging sub-gingival pathogens than from TiZr alloys and zirconia variants. Combined with previous work employing a co-culture model consisting of human gingival fibroblasts and supra-gingival oral bacteria, results point to a different material selection to stimulate the formation of a soft tissue seal as compared to preservation of osseointegration under the unsterile conditions of the oral cavity.

关键词： biofilm co-culture dental implant osteoblasts sub-gingival pathogens titanium-zirconium alloy

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Influence of Fluoride Content of Artificial Saliva on Metal Release from 17-4 PH Stainless Steel Foam for dental implant Applications

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Journal of Materials Science & Technology 2013年第6期29卷 582-588页

作者： Ilven Mutlu Enver Oktay Department of Metallurgical and Materials Engineering Istanbul UniversityIstanbulTurkey

Highly porous 17-4 PH stainless steel foam for implant applications was produced by space holder technique. Metal release and weight loss from 17-4 PH stainless steel foams were investigated in fluoride added artificial saliva environment by static immersion test. An inductively coupled plasma-mass spectrometer was employed to measure the concentrations of various metal ions. Effects of fluoride content of artificial saliva on metal release and weight loss from the steel foams were investigated. Effects of immersion time, pH value and process parameters on the weight loss and metal release were determined. Pore morphology, pore size and mechanical properties of the 17-4 PH stainless steel foams were also characterized.

关键词： Metal release dental implant Metal foam Fluoride Artificial saliva

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Surface treatment of titanium dental implant with H2O2 solution

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1281-1286页

作者： Mohammad Khodaei Kamran Amini Alireza Valanezhad Ikuya Watanabe Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayegan ***Iran Center for Advanced Engineering Research Majlesi BranchIslamic Azad UniversityIsfahan 196151194Iran Department of dental and Biomedical Materials Science Graduate School of Biomedical SciencesNagasaki University1-7-1 SakamotoNagasaki 852-8588Japan

The surface treatment is important for titanium and its alloys as promising candidates for dental implantation due to their bioinert surface.Titanium surface samples were modified using H2O2 solution at different times up to 72 h to boost their bioactivity.According to the results of the field emission scanning electron microscopy test,some nanostructures are formed on the surface of treated titanium samples and increased in size by increasing the time of treatment up to 24 h.After 24 h of application,the sharpness of nanostructures decreased and the micro-cracks and discontinuity in the coating surface increased.The results of the X-ray diffraction study and Raman spectroscopy revealed that anatase(TiO2)was formed on the surface of treated titanium samples.The peak intensity of Raman spectroscopy increased with an improvement in treatment time of up to 24 h and then decreased due to the discontinuity of the coating.Full wettability and ability to form apatite were reached at 6 h of treatment.It is clear that the treatment time has a significant effect on the surface treatment of titanium using the H2O2 solution.

关键词： titanium implant surface treatment hydrogen peroxide anatase dental implant

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