检索结果-南通市图书馆

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lei ZHANG~(1,*),Ning-Ning SONG~1,Jia-Yin CHEN~1,Ying HUANG~1,He LI~2,Yu-Qiang DING~(1,*) 1 Department of Anatomy and Neurobiology,Tongji University School of Medicine,Shanghai 200092,China 2 Division of Histology and Embryology,Department of Anatomy,Key Laboratory of Nervous System Diseases, Ministry of Education of China,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

＜正＞Self-avoidance is a mechanism by which dendrites from the same neuron repel one another in order to establish uniform coverage of the dendritic *** importance of self-avoidance for the development of complex arborization patterns has been highlighted by studies of Drosophila sensory and mouse retinal ***,it is unclear whether branch patterning in the mammalian central nervous system is also governed by this *** reduced Satb2 expression in a population of layerⅡ/Ⅲpyramidal neurons in vivo by RNA interference,and found that the somas of Satb2-deficient neurons clumped together and their dendrites failed to expand laterally but instead formed *** experiments showed that reducing Satb2 caused the adhesion of not only neighboring Satb2-deficient neurons but also neighboring wild-type *** results indicate a cell autonomous and non-cell autonomous role for Satb2 in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons.

关键词： adhesion dendritic arborization in utero electroporation repulsion self-avoidance

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates dendritic Morphology in Drosophila

引用

Neuroscience Bulletin 2020年第10期36卷 1147-1157页

作者： Ting Zhang Daxiao Cheng Cunjin Wu Xingyue Wang Qiang Ke Huifang Lou Liya Zhu Xiao-Dong Wang Shumin Duan Yi-Jun Liu Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of MedicineHangzhou 310058China Department of Diagnostics Hangzhou Normal University Medical SchoolHangzhou 311121China Department of Laboratory Medicine Hangzhou Normal University Affiliated HospitalHangzhou 310015China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Mental Health Center Zhejiang University School of MedicineHangzhou 310058China

The main lysosomal protease cathepsin D(cathD)is essential for maintaining tissue homeostasis via its degradative function,and its loss leads to ceroid accumulation in the mammalian nervous system,which results in progressive *** evidence implies non-proteolytic roles of cathD in regulating various biological processes such as apoptosis,cell proliferation,and *** these lines,we here showed that cathD is required for modulating dendritic architecture in the nervous system independent of its traditional degradative *** cathD depletion,class I and class III arborization(da)neurons in Drosophila larvae exhibited aberrant dendritic morphology,including overbranching,aberrant turning,and elongation *** of wild-type cathD or its proteolyticallyinactive mutant dramatically abolished these morphological ***,cathD knockdown also led to dendritic defects in the adult mushroom bodies,suggesting that cathD-mediated processes are required in both the peripheral and central nervous *** together,our results demonstrate a critical role of cathD in shaping dendritic architecture independent of its proteolytic function.

关键词： Cathepsin D dendritic arborization Sensory neuron Mushroom body Actin Drosophila

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of GSM 1800 MHz on dendritic development of cultured hippocampal neurons

引用

Acta Pharmacologica Sinica 2007年第12期28卷 1873-1880页

作者： Wei NING~2,Shu-jun XU~2,Huai CHIANG~3,Zheng-ping XU~3,Su-ya ZHOU~2,Wei YANG,Jian-hong LUO~(2,4)~2 Department of Neurobiology,Zhejiang University School of Medicine,Hangzhou 310058,China ~3 Bioelectromagnetics Laboratory,ZhejiangUniversity School of Medicine,Hangzhou 310058,China Department of Neurobiology Zhejiang University School of Medicine Hangzhou China Bioelectromagnetics Laboratory Zhejiang University School of Medicine Hangzhou China

Aim:To evaluate the effects of global system for mobile communications (GSM)1800 MHz microwaves on dendritic filopodia,dendritic arborization,and spinematuration during development in cultured hippocampal neurons in ***:The cultured hippocampal neurons were exposed to GSM 1800 MHz microwaveswith 2.4 and 0.8 W/kg,respectively,for 15 min each day from 6 days in vitro (DIV6)to *** subtle structures of dendrites were displayed by transfection withfarnesylated enhanced green fluorescent protein (F-GFP) and GFP-actin on DIV5into the hippocampal ***:There was a significant decrease in thedensity and mobility of dendritic filopodia at DIV8 and in the density of maturespines at DIV14 in the neurons exposed to GSM 1800 MHz microwaves with2.4 W/*** addition,the average length of dendrites per neuron at DIV10 andDIV14 was decreased,while the dendritic arborization was unaltered in ***,there were no significant changes found in the neurons ex-posed to the GSM 1800 MHz microwaves with 0.8 W/***:Thesedata indicate that the chronic exposure to 2.4 W/kg GSM 1800 MHz micro-waves during the early developmental stage may affect dendritic developmentand the formation of excitatory synapses of hippocampal neurons in culture.

关键词： global system for mobile communications microwaves dendritic filopodia dendritic arborization spines hippocampal neurons

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus

引用

Neuroscience Bulletin 2021年第3期37卷 298-310页

作者： Yang Ni Bin Liu Xiaojing Wu Junhua Liu Ru Ba Chunjie Zhao Key Laboratory of Developmental Genes and Human Diseases Ministry of EducationSchool of MedicineSoutheast UniversityNanjing 210009China

The Wnt signaling pathway plays key roles in various developmental ***5a,which activates the non-canonical pathway,has been shown to be particularly important for axon guidance and outgrowth as well as dendrite ***,the mechanism underlying the regulation of Wnt5a remains ***,through conditional disruption of Foxg1 in hippocampal progenitors and postmitotic neurons achieved by crossing Foxg1~(fl/fl)with Emx1-Cre and Nex-Cre,respectively,we found that Wnt5a rather than Wnt3a/Wnt2b was markedly *** of Foxg1 had the opposite effects along with decreased dendritic complexity and reduced mossy fibers in the *** further demonstrated that FOXG1 directly repressed Wnt5a by binding to its promoter and one enhancer *** results expand our knowledge of the interaction between Foxg1 and Wnt signaling and help elucidate the mechanisms underlying hippocampal development.

关键词： Wnt5a Foxg1 hippocampus granule cell pyramidal neuron dendritic arborization mossy fiber Wnt

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction between the actin cytoskeleton and the cadherin/catenin complex in regulating dendritic morphogenesis

Interaction between the actin cytoskeleton and the cadherin/...

引用

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Z.J TAN~(1,2),Y.YU~(1,2),Y.PENG~1,X YU~1 1 Institute of Neuroscience and Key Laboratory of Neurobiology,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,Shanghai,China 2 Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China

＜正＞As dendrites are the primary sites through which neurons receive inputs from contacting axons,dendritic development and arborization are critical to neural circuit formation and synaptic *** have previously shown that the cadherin/catenin complex is critical for activity-dependent dendritic *** we further demonstrate that inter-neuronal cadherin-cadherin interactions play an important role in regulating dendritic arborization,as expression of the extracellular domain of N-cadherin in soluble form reduces dendritic arborization and blocks the effects of neural activity,as well as over-expression of beta-catenin or alphaN-catenin on increasing dendritic *** addition,we show the ability of alphaN-catenin to bind to the actin cytoskeleton is required for regulation of dendritic arbor development by the cadherin/catenin complex,an effect that cannot be mimicked by the equivalent domain of ***,we show using latrunculin A treatment that actin dynamics is required for enhancement but not maintenance of dendritic arbors.

关键词： dendritic arborization neural activity alphaN-catenin beta-catenin actin

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：