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deltonin enhances gastric carcinoma cell apoptosis and chemosensitivity to cisplatin via inhibiting PI3K/AKT/mTOR and MAPK signaling

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World Journal of Gastrointestinal Oncology 2023年第10期15卷 1739-1755页

作者： Lin Yang Ya-Nan Liu Yi Gu Qi Guo Intensive Care Unit Second Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Obstetrics and Gynecology Second Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Nursing Department of Obstetrics and Gynecology Second Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Radiotherapy Second Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND As an active ingredient derived from Dioscorea zingiberensis ***,deltonin has been reported to show anti-cancer effects in a variety of *** To investigate the role and mechanism of action of deltonin in promoting gastric carcinoma(GC)cell apoptosis and chemosensitivity to *** The GC cell lines AGS,HGC-27,and MKN-45 were treated with deltonin and then subjected to flow cytometry and 3-(4,5-dimethylthiazol-2-yl)-3,5-diphenyltet-razolium bromide assays for cell apoptosis and viability *** blot analysis was conducted to examine alterations in the expression of apoptosis-related proteins(Bax,Bid,Bad,and Fas),DNA repair-associated proteins(Rad51 and MDM2),and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin(PI3K/AKT/mTOR)and p38-mitogen-activated protein kinase(MAPK)axis ***,the influence of deltonin on GC cell chemosensitivity to cisplatin was evaluated both in vitro and in *** deltonin treatment weakened viability,enhanced apoptosis,and dampened DNA repair in GC cell lines in a dose-dependent ***,deltonin mitigated PI3K,AKT,mTOR,and p38-MAPK ***-173,an inhibitor of PI3K,attenuated GC cell viability and abolished deltonin inhibition of GC cell viability and PI3K/AKT/mTOR and p38-MAPK pathway *** also promoted the chemosensitivity of GC cells to cisplatin via repressing GC cell proliferation and growth and accelerating *** deltonin can boost the chemosensitivity of GC cells to cisplatin via inactivating p38-MAPK and PI3K/AKT/mTOR signaling.

关键词： deltonin Gastric carcinoma Cisplatin Apoptosis Chemotherapy Axis

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