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Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma

World Journal of Gastroenterology 2008年第11期14卷 1670-1681页

作者： Patrick Arbuthnot Liam Jed Thompson Antiviral GeneTherapy Research Unit Department of Molecular Medicine andHaematologyUniversity of the Witwatersrand Medical SchoolPrivate Bag 3WITS 2050South Africa

Primary liver cancer is the fifth most common malignan- cy in the world and is a leading cause of cancer-related *** treatment for hepatocellular carcino- ma(HCC),the commonest primary liver cancer,is rarely curative and there is a need to develop therapy that is more *** and powerful gene silencing that can be achieved by activating RNA interference(RNAi) has generated enthusiasm for exploiting this pathway for HCC *** studies have been carried out with the aim of silencing HCC-related cellular oncogenes or the hepatocarcinogenic hepatitis B virus(HBV)and hepatitis C virus(HCV).Proof of principle studies have demonstrated promising results,and an early clinical trial assessing RNAi-based HBV therapy is currently in *** the data augur well,there are several significant hurdles that need to be overcome before the goal of RNAi-based therapy for HCC is ***- larly important are the efficient and safe delivery of RNAi effecters to target malignant tissue and the limitation of unintended harmful non-specific effects.

关键词： RNA interference Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Molecular pathogenesis delivery vectors

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Recent advances in polymeric biomaterials-based gene delivery for cartilage repair

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Bioactive Materials 2020年第4期5卷 990-1003页

作者： Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022PR China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou510515PR China College of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026PR China Center for Materials Synthetic Biology CAS Key Laboratory of Quantitative Engineering BiologyShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China Department of Histology and Embryology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515PR China

Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of ***,both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably,and new strategies for integrative cartilage repair are *** therapy provides local production of therapeutic factors,especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes,achieve accurate spatiotemporally release of gene products,thus provideing long-term treatment for cartilage *** widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated *** them,polymeric biomaterials are particularly attractive due to their tunable physiochemical properties,as well as excellent adaptive *** paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair,with an emphasis on the important role of polymeric biomaterials in delivery systems.

关键词： Cartilage repair Gene therapy Polymeric biomaterials delivery vectors Gene-activated matrices

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