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Quality of reporting and adherence to the ARRIVE guidelines 2.0 for preclinical Degradable metal research in animal models of bone defect and fracture:a systematic review

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Regenerative Biomaterials 2022年第1期9卷 1167-1181页

作者： Fengxing Ding Kaiyan Hu Xia Liu Chen Liu Jinwei Yang Xinli Shi Bin Liu Mei Wu Zhe Wang Liyuan Feng Jiazhen Zhang Bin Ma School of Basic Medical Sciences Evidence-Based Medicine CenterLanzhou UniversityNo 199Donggang West RoadChengguan DistrictLanzhou 730000P.R.China Department of Pharmacology School of Basic Medical ScienceLanzhou UniversityLanzhou 730000P.R China Reproductive Medicine Center Gansu Provincial Maternity and Child-Care HospitalLanzhou 730000P.R.China Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081P.R China Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000P.R.China

In vivo testing is crucial for the evaluation of orthopedic implant efficacy and safety.However,the translation and reproducibility of preclinical animal experiments are not always satisfactory,and reporting quality is among the essential factors that ensure appropriate delivery of information.In this study,we assessed the reporting quality of in vivo investigations that examined the use of Degradable metal materials in fracture or bone defect repair.We employed scientific databases,such as PubMed,EMBASE,Web of Science,Cochrane Library,CNKI,WanFang,VIP and Sinomed to screen for in vivo investigations on fracture or bone defect repair using Degradable metal materials,and extracted both epidemiological and main characteristics of eligible studies,and assessed their reporting quality using the ARRIVE guidelines 2.0.Overall,263 publications were selected,including 275 animal experiments.The overall coincidence rate of Essential 10(22 sub-items)and Recommended Set(16 sub-items)were 42.0%and 41.5%,respectively.Based on our analysis,the reporting quality of the published in vivo investigations examining fracture/bone defect repair with Degradable metal materials was low,and there was a lack of transparent,accurate and comprehensive reporting on key elements of the experimental design and other elements that are meant to avoid bias.

关键词： ARRIVE 2.0 animal research Degradable metal bone defect fracture systematic review

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In vitro and in vivo degradability,biocompatibility and antimicrobial characteristics of Cu added iron-manganese alloy

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Journal of Materials Science & Technology 2021年第25期84卷 159-172页

作者： Santanu Mandal Vijay Kishore Madhuparna Bose Samit Kumar Nandi Mangal Ro Department of metallurgical and Materials Engineering Indian Institute of Technology-KharagpurKharagpur 721302India Department of Veterinary Surgery&Radiology West Bengal University of Animal&Fishery SciencesKolkata 700037India Department of Biotechnology Indian Institute of TechnologyKharagpur 721302India

In recent years,iron(Fe)based Degradable metal is explored as an alternative to permanent fracture fixation devices.In the present work,copper(Cu)is added in Fe-Mn system to enhance the degradation rate and antimicrobial properties.Fe-Mn-x Cu(x=0.9,5 and 10 wt.%)alloys are prepared by the meltingcasting-forging route.XRD analysis confirms austenite phase stabilization due to the presence of Mn and Cu.As predicted by Thermo-Calc calculations,Cu rich phase precipitations are noticed along the austenite grain boundaries.Degradation behaviours of Cu added Fe-Mn alloys are investigated through static immersion and electrochemical polarization where enhanced degradation is found for higher Cu added alloys.When challenged against E.Coli bacteria,the Fe-Mn-Cu alloy media extract shows a significant bactericidal effect compare to the base alloy.In vitro cytocompatibility studies,as determined using MG63 and MC3T3-E1 cell lines,indicate increased cell density as a function of time for all the alloys.When implanted in rabbit femur,the newly developed alloy does not show any kind of tissue necrosis around the implants.Better osteogenesis and higher new bone formation are observed with Fe-Mn-10 Cu alloy as evident from micro-computed tomography(μ-CT)and fluorochrome labelling.

关键词： Iron-manganese alloy Degradable metal In vitro Micro-CT

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