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The effect of enzymes on the in vitro degradation behavior of mg alloy wires in simulated gastric fluid and intestinal fluid

引用

Bioactive Materials 2022年第1期7卷 217-226页

作者： Yue Zhang Jian Cao Xianli Wang Huan Liu Yi Shao Chenglin Chu Feng Xue Jing Bai School of Materials Science and Engineering Southeast UniversityJiangningNanjing 211189JiangsuChina Jiangsu Key Laboratory for Advanced Metallic Materials JiangningNanjing 211189JiangsuChina Institute of Biomedical Devices(Suzhou) Southeast UniversitySuzhou 215163JiangsuChina d Peking University People’s Hospital Xi ChengBeijing 100044China College of Mechanics and Materials Hohai UniversityNanjing211100China

With an upsurge of biodegradable metal implants,the research and application of mg alloys in the gastrointestinal environment of the digestive tract have been of great *** enzymes,mainly pepsin in the stomach and pancreatin in the small intestine,are widespread in the gastrointestinal tract,but their effect on the degradation of mg alloys has not been well *** this study,we investigated the impacts of pepsin and pancreatin on the degradation of mg-2Zn alloy *** results showed that the pepsin and pancreatin had completely different even the opposite effects on the degradation of mg,although they both affected the degradation product *** degradation rate of mg wire declined with the addition of pepsin in simulated gastric fluid(SGF)but rose with the addition of pancreatin in simulated intestinal fluid(SIF).The opposite trends in degradation rate also resulted in completely different degradation morphologies in wires surface,where the pitting corrosion in SGF was inhibited because of the physical barrier effect of pepsin *** contrast,the adsorption of pancreatin affected the integrity of magnesium hydrogen phosphate film,causing a relatively uneven degraded *** results may help us to understand the role of different digestive enzymes in the degradation of magnesium and facilitate the development and clinical application of magnesium alloy implanted devices for the digestive tract.

关键词： degradable mg alloy Pepsin Pancreatin Gastrointestinal Digestive tract

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