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Utilization of deep neuromuscular blockade combined with reduced abdominal pressure in laparoscopic radical gastrectomy for gastric cancer:An academic perspective

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1405-1415页

作者： Yi-Wei Zhang Yong Li Wan-Bo Huang Jue Wang Xing-Er Qian Yu Yang Chang-Shun Huang Department of Anesthesiology Ningbo First HospitalNingbo 315016Zhejiang ProvinceChina

BACKGROUND Few studies have examined the specific efficacy of deep neuromuscular blockade(NMB)combined with pneumoperitoneal pressure reduction in laparoscopic radical gastrectomy(LRG)in the *** To investigate the application effect of deep neuromuscular blockade(NMB)combined with reduced pneumoperitoneum pressure in LRG for gastric cancer(GC)in elderly patients and its influence on *** Totally 103 elderly patients with GC treated in our hospital between January 2020 and January 2022 were retrospectively *** them,45 patients treated with surgery based on deep NMB and conventional pneumoperitoneum pressure were assigned to the control group,while the rest of the 58 patients who underwent surgery based on deep NMB and reduced pneumoperitoneum pressure were assigned to the observation *** two groups were compared in the changes of the Leiden-surgical rating scale score,serum tumor necrosis fact-α(TNF-α)and interleukin 6(IL-6)before and after *** visual analogue scale(VAS)was adopted for evaluating the shoulder pain of patients at 8 h,24 h and 48 h after the *** driving pressure of the two groups at different time points was also ***,the operation time,pneumoperitoneum time,infusion volume,blood loss,extubation time after surgery,residence time in the resuscitation room,TOF%=90%time and post-anesthetic recovery room(PACU)stay time were all recorded,and adverse PACU-associated respiratory events were also *** postoperative hospitalization time and postoperative expenses of the two groups were counted and *** No significant difference was found between the two groups at the time of skin incision,60 minutes since the operation and abdominal closure after surgery(P>0.05).The observation group exhibited significantly lower VAS scores than the control group at 24 and 48h after surgery(P<0.05).Additionally,the observation group had significantly lower driving pressure than the c

关键词： deep neuromuscular blockade Low pneumoperitoneum pressure Elderly Laparoscopy Gastric cancer Radical gastrectomy Inflammation

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