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Modulation of gut microbiota by berberine and decocted Coptis chinensis *** a high-fat diet-induced metabolic syndrome rat model

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Journal of Traditional Chinese Medical Sciences 2017年第2期4卷 149-157页

作者： Ti Huang Xu Yan Xiaoguang Yan Fei Huang Jie Li Juncai Xiao Yi Li Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Department of Traditional Chinese Medicine Beijing HospitalBeijing 100730China BGI College Shenzhen518083China Department of Endocrinology Traditional Chinese Medicine Hospital in Pinggu DistrictBeijing101200China

Objective:To investigate the effect of decocted Coptis chinensis Franch.(Huanglian Jianji,黄连煎剂,HLJJ) and berbenne on the gut microbiota of the rats with metabolic syndrome (MS) induced by high-fat diet (HFD).Methods:Sixty Sprague Dawley rats were randomly divided into normal diet (ND) group (n =15)and HFD group (n =45).After 8 weeks of feeding,the HFD group was further divided into three groups:a group provided with a combination of HLJJ and HFD for 4 weeks,a group provided with a combination of berberine and HFD for 4 weeks,and a group supplied only with HFD for 4 consecutive *** fat weight,serum high-density lipoproteincholesterohC (HDL-C),lowdensity lipoproteincholesterol-C (LDL-C) and irisin levels were *** addition,the V3-V4 region of the cecum microbiota 16S rRNA gene amplicon was sequenced on the Illumina MiSeq ***:MS was successfully induced in the rats with HFD for 8 *** 12 weeks,serum irisin levels in the HFD + berberine group were significantly increased compared with those in the HFD group (P <.05).The high-quality tags were delineated into 1149 operational taxonomic units at a 97% similarity ***,at the genus level,Akkermansia muciniphila (***),Bacteroides,and Ruminococcus were markedly increased,whereas Candidatus arthromitus,Prevotella,Phascolarctobacterium were in great decrease in the HLJJ group and the berberine group,compared with the HFD *** abundance of ***,Ruminococcus gnavus and Bacteroides was significantly higher in the berberine group,whereas,the abundance of Oscillospira was lower in the berberine group,compared with the HLJJ ***:HLJJ and berberine changed the gut microbiota in rats with *** mechanism underlying the treatments of berberine and HLJJ on HFD-induced MS is partly different.

关键词： Metabolic syndrome Gut microbiota decocted Coptis chinensis Franch.(HLJJ) Berberine High-fat diet

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