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Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats

引用

Journal of Traditional Chinese Medicine 2013年第5期33卷 651-657页

作者： Ruiyu Li Meng Li Kaoshan Guo Bin Li Jinjie Hou Liping Wu Xianyun Liu Institute for Integrated Traditional and Western Medicine the Second Affiliated Hospital of Xingtai Medical College Health Team of Hetian Prefecture Detachment Xin-jiang Armed Police Corps Department of Biochemistry Hebei Medical University Clinical Laboratory Xingtai People's Hospital

OBJECTIVE:Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with ***:Total 296 patients with non-insulin dependent diabetes mellitus(NIDDM)were randomly divided into two groups.A treatment group of 164patients(208 ears)was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation.A control group of 132 patients(184ears)was treated with glibenclamide and conventional drug treatment for *** following were observed:hearing,fasting plasma glucose(FPG),2 h postprandial plasma glucose(2hPG),24 h urine glucose(24hUG),improvement of main symptoms,platelet function,and changes in superoxidedismutase(SOD)and lipid peroxide(LPO)*** animal studies,Kunming mice,weighing 18-22 g were *** of the mice were males and half were *** rats,weighing 80-120 g were *** of the rats were males and half were *** Wistar rats,weighing 200-220 g,were also *** acute and chronic toxicity was ***:The hearing improvement was 56.7%in the treatment group and 26.6%in the control ***,2hPG,and 24hUG were improved significantly(P<0.05,P<0.01,P<0.01,respectively)in the treatment group and 2hPG and 24hUG improved significantly in the control group(P<0.05,P<0.05).The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P<0.01).There was no significant difference in FPG between the two groups(P<0.05).Main symptoms in the treatment group were significantly more improved than those in the control group(P<0.05,P<0.01).In the treatment group,platelet adhesion and aggregation,SOD,and LPO were all significantly improved from before treatment(P<0.05,P<0.01).However,in the control group,except LOP(P<0.05),there were no significant differences from before treatment to after(P<0.05).In animal studies,no obvious acute or long-term toxicity was observed from ca

关键词： deafness hearing diabetes mellitus hypoglycemic anti-deafness capsules pharmacodynamics test toxicology

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