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Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury

Neural Regeneration Research 2012年第24期7卷 1866-1872页

作者： Haomei Tian Hong Zhang Junbao Zhu Juan Zhang Hening Cai Yuchen Zhang Chutao Chen Key Laboratory of Meridians and Viscera Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Liuzhou Hospital of Traditional Chinese Medicine Liuzhou 545001Guangxi Zhuang Autonomous RegionChina Ningxiang Hospital of Traditional Chinese Medicine Ningxiang 410600Hunan ProvinceChina Postgraduate College Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Laboratory of Acupuncture Bioinformatics Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina

A middle cerebral artery occlusion-model was established in rats using the improved thread embolism *** were treated with acupuncture at either dazhui（DU14）,Renzhong（DU26）, Baihui（DU20）,or a non-meridian *** with protein-chip technology showed that the level of protein phosphorylation in both groups was upregulated or downregulated depending on the signaling pathway compared with the model group that did not receive *** of proteins showing downregulated phosphorylation revealed that five signaling pathways were activated in the acupuncture-treatment group,while only two were activated in the acupuncture-control *** contrast,analysis of proteins showing upregulated phosphorylation revealed only one pathway was activated in the acupuncture-treatment group,whereas four pathways were activated in the acupuncture-control ***,the number of activated proteins in the acupuncture-treatment group was not only higher than the acupuncture-control group,but unlike the acupuncture-control group,the majority of activated proteins were key proteins in the signaling *** findings indicate that acupuncture at specific points can activate multiple signaling pathways to promote the restoration of brain tissue following ischemic injury,and that this is based on a combination of effects resulting from multiple pathways,targets,and means.

关键词： acupuncture cerebral ischemia dazhui Baihui Renzhong protein-chip technology signal-transduction pathways nerve injury brain injury ischemic injury neural regeneration

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