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darwinian selection within an individual or somatic selection: facts and models

Journal of Molecular Cell Biology 2019年第8期11卷 719-722页

作者： Reiner A.Veitia Institut Jacques Monod Universite Paris Diderot 75013 Paris France Universite Paris-Diderot 75013 Paris France

There are known cases where a cell sub-population bearing a selective advantage tends to or eventually replaces another cell subpopulation within an organism. This process is supposed to underlie the purging of the most frequent mitochon-drial DNA pathogenic variant from leuko-cytes and other tissues. It is also likely to explain the normal increase of sex chromo-some aneuploidy in human leukocytes with age or under pathological conditions and the expansion of a cell subpopulation after the spontaneous in vivo reversion to normal of an inherited pathogenic variant.

关键词： darwinian selection facts models

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The Principle of Concerted Evolution Between Interacting Proteins—darwinian Selection at Molecular Level

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Chinese Science Bulletin 1993年第16期38卷 1396-1401页

作者：贺福初吴祖泽 Department of Experimental Hematology Beijing Institute of Radiation Medicine

The neutral theory raised by Motoo Kimura in 1968 asserts that 'the great majority of evolutionary changes at the molecular level, as revealed by comparative studies of protein and DNA sequences. are caused not by Dar... 详细信息

关键词： Interacting proteins concerted evolution neutral theory darwinian selection

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darwinian Selection in Prostate Cancer and Medical Treatment

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International Journal of Clinical Medicine 2017年第6期8卷 353-367页

作者： Chunjiao Song Medical Research Center Shaoxing People’s Hospital/Shaoxing Hospital of Zhejiang University Shaoxing China

Organisms evolved into different species to adapt to the environment according to the laws of darwinian evolution. In a single life, prostate cancer cells can also evolve into tumor stem cells to adapt to the microenvironment, such as different chemotherapeutic drugs. These cancer cells become an unrestricted growth group relatively independent of the individual. The present review attempts to establish evidence that prostate cancer cells may survive by hormonotherapy and chemotherapy by gene amplification, mutation, and alternative splicing. Simultaneously, novel treatment strategies have been cited and evaluated, avoiding the resistance mechanisms.

关键词： Prostate Cancer Androgen Receptor Tumor Microenvironment darwinian Selection

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