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Effect of danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions

引用

World Journal of Gastroenterology 2013年第19期19卷 2963-2968页

作者： Zhao-Hui Fang Yan Liu Tao-Tao Bao Ying-Qun Ni Jian Liu Guo-Bin Shi Ji-Ping Wu Jun-Ping Yang Hong Zhang Department of Endocrinology the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine Department of Gastroenterology the People's Hospital of Taihu Country Department of Gastroenterology Wuhai Mongolian and Traditional Chinese Medicine Hospital

AIM:To investigate the effect of danzhijiangtang capsule(DJC) on monocyte chemoattractant protein-1(MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus(T2DM) subclinical vascular ***:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a control group and treatment group of 31 cases *** antidiabetic therapy with routine western medicine was conducted in both groups,and the treatment group was additionally treated with *** treatment course for both groups was 12 *** and after treatment,the total efficiency and traditional Chinese medicine(TCM) syndrome score were *** fasting plasma glucose(FPG),2-h plasma glucose(2hPG),fasting insulin(FINS),insulin resistance index(IRI),hemoglobin(Hb)A1c,blood lipids,and hemorheology indices were *** addition,the levels of vascular endothelial growth factors including thrombomodulin(TM),von Willebrand factor(vWF),P-selectin and MCP-1 mRNA were ***:After 12 wk of treatment,the TCM syndrome score was significantly decreased compared to before treatment in both *** treatment,FPG,2hPG,HbA1c,FINS,IRI,total cholesterol,triglycerides,low-density lipoprotein,high-density lipoprotein,whole blood low shear specific viscosity,plasma specific viscosity,TM,vWF,P-selectin and MCP-1 mRNA were significantly improved compared to before treatment in both *** treatment,the total efficiency and TCM syndrome score in the treatment group were better than in the control ***,IRI,whole blood high shear specific viscosity,plasma specific viscosity,TM,vWF,P-selectin and MCP-1 mRNA level in the treatment group were significantly reduced after treatment compared with control ***:DJCs are efficacious in supplementing qi,nourishing yin and invigorating blood circulation,and upregulate MCP-1 mRNA expression in patients with T2DM subclinical vascular lesions.

关键词： danzhijiangtang capsule Type 2 diabetes mellitus Subclinical vascular lesions Monocyte chemoattractant protein-1

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