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Chemical Fingerprint for Identification and Quality Control of Saccharides in Danhong Injection Based on HPLC-ELSD with Chemometrics

引用

Chemical Research in Chinese Universities 2019年第5期35卷 782-787页

作者： LI Hao YANG Zhenzhong WANG Jiaojiao AN Yun WANG Chenchen GUO Xiaoguang WANG Yi Tianjin University of Traditional Chinese Medicine Tianjin 300193P.R.China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058P.R.China Heze Medical College Heze 274000P.R.China Shandong Danhong Pharmaceutical Co. Ltd.Heze 274000P.R.China

Chemical fingerprinting has been widely used for the quality control of complex natural products including traditional Chinese medicines and botanical drugs. However, there is still lack of appropriate method to monitor the batch-to-batch consistency of hydrophilic constituents, such as saccharides and oligosaccharides. In the present study, we developed a novel approach based on high performance liquid chromatography with evaporative light scattering detector(HPLC-ELSD) for establishing saccharide fingerprinting of Danhong Injection(DHI), which is a widely used botanical drug for treating cardiovascular diseases. Major saccharides in DHI were isolated and four compounds including fructose, glucose and two oligosaccharides were identified. The structures of two novel saccharides named glycerol-1-O-galactfpyranosyl-(1→4)-O-arabmofuranoside, and glycerol-1-O-galactpyranosyl-(1→4)[O-arabmfuranosyl-(1→3)]-O-arabinofuranoside were confirmed by NMR, HR-ESI-MS and GC-MS for the first time. The establishment approach was successfully applied to distinguishing 12 batches of DHI from other botanical drugs with the aid of principle component analysis as well as to evaluating batch-to-batch consistency with the help of calculating similarity of tmgerprints. Our findings indicate that the chemical fingerprint of saccharides can be a useful tool for the quality control of complex natural products.

关键词： danghong injection Saccharide Fingerprint Carthami Flos

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