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Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of dxms-induced insulin resistant hepg2 cells

引用

Natural Products and Bioprospecting 2014年第4期4卷 197-206页

作者： Jun-Zeng Ma Li-Xin Yang Xiao-Ling Shen Ji-Huan Qin Li-Lan Deng Selena Ahmed Hong-Xi Xu Da-Yuan Xue Jiang-Xia Ye Gang Xu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China College of Life and Environmental Science Minzu University of China27 ZhongGuanCun South AvenueBeijing 100086China Laboratory of Chinese Herbal Drug Discovery Tropical Medicine InstituteGuangzhou University of Chinese MedicineGuangzhou 510405People’s Republic of China Southwest Forestry University Kunming 650224People’s Republic of China Sustainable Food and Bioenergy Systems Program Department of Health and Human DevelopmentMontana State UniversityBozemanMT 59717USA Shanghai University of Traditional Chinese Medicine Shanghai 201203People’s Republic of China

Medicinal plants have a long history of use in China to treat diabetic *** Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic *** on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey,16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance *** biological activity of 16 medicinal plants was tested on dexamethasone(dxms)-induced insulin resistant hepg2 *** result shows that 11 of the 16 medicinal plants enhanced glucose uptake of dxms-induced insulin resistant hepg2 cells,thereby demonstrating their ability to increase insulin sensitivity,other five medicinal plants including Astragalus membranaceus were found *** study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.

关键词： Traditional medicinal plants Diabetes Anti-insulin resistance bioactivity dxms-induced insulin resistant hepg2 cells

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