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Fluorescence Spectroscopy Studies of the Effects of Pyrethroids on the dppc Vesicles

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Biomedical and Environmental Sciences 1992年第2期5卷 109-114页

作者： CONGRONGJUAN ZHOUZHE 等 DepartmentofChemistry XiamenUniversityFujian361005 DepartmentofChemistry XiamenUniversityFujian3610

The interactions of pyrethroids with membrane lipids have been studied by means of fluorescent membrane probe DPH. Pyrethroids located in the interior hydrophobic regions of the lipid bilayer, differed in their effectiveness of lowering the phase transition temperature and in their ability to broaden the temperature range of this transition. With the increase in the concentrations of pyrethroids, the effects of disordering hydrocarbon packing were increased by pyrethroids. Fluorescence polarizations (P) were decreased in gel state, but not changed in fluid state by permethrin. The pyrethroids containing a cyano substituent could not only disturb the hydrocarbon packing in the bilayer core, but also cause collisional quenching of DPH fluorescence in gel state, P were decreased, then were increased and at last were decreased slightly again as the concentrations were increased, in fluid state P were not changed substantially at low concentrations and were increased obviously when the concentrations were higher.

关键词： Fluorescence Spectroscopy Studies of the Effects of Pyrethroids on the dppc Vesicles dppc

STUDY ON THE EFFECTS OF THE ANTITUMOR DRUG cis-DDP ON THE PHASE BEHAVIOR OF dppc LIPOSOMES AND MOLECULAR MECHANISM OF THE INTERACTION

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Chinese Science Bulletin 1991年第2期36卷 149-153页

作者：沈子威孙中平赵南明 Department of Biological Science and Biotechnology Tsinghua University Beijing 100084 PRC

Cis-diamminedichloroplatinum (Ⅱ) (cis-DDP, also cisplatin) is the first heavy metal coordination compound to be the leading and most widely used antitumor *** molecular structures of cis-DDP and trans-DDP (inactive) ... 详细信息

关键词： cis-DDP dppc liposomes ammine ligands phosphofipids.

Eu^(3+)和Al^(3+)离子对dppc人工膜脂双层主相变温度的影响

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高等学校化学学报 1998年第10期19卷 1553-1555页

作者：徐洪文傅素冉张束空许振华烟台大学应用化学系北京大学化学系

天然生物膜组成复杂，直接用于研究困难较大．由于天然生物膜中脂分子的行为与人工脂双层膜的行为十分类似，故我们用单一磷脂制备人工脂双层膜来研究金属离子对其主相变温度的影响．膜的动力学性质依靠膜平面内的液体环境，决定膜流动... 详细信息

天然生物膜组成复杂，直接用于研究困难较大．由于天然生物膜中脂分子的行为与人工脂双层膜的行为十分类似，故我们用单一磷脂制备人工脂双层膜来研究金属离子对其主相变温度的影响．膜的动力学性质依靠膜平面内的液体环境，决定膜流动性的膜成分是磷脂分子．磷脂的重要性...

关键词：磷脂主相变温度 dppc 脂双层膜铕铝生物膜

dppc与MMA混合单层LB膜缺陷结构的AFM研究

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人工晶体学报 2008年第1期37卷 43-48页

作者：许小晶邓穗平郑辉蔡继业欧阳健明暨南大学生物矿化与结石病防治研究所广州510632

采用原子力显微镜（AFM）研究了转移到疏水石英基片上的二棕榈酰磷酯酰胆碱（dppc）与不同浓度聚合物单体分子甲基丙烯酸甲酯（MMA）的混合物所形成的单层LB膜及其缺陷的微结构,研究了沉积压对缺陷的影响。当MMA的摩尔比为33%（即MMA∶D... 详细信息

采用原子力显微镜（AFM）研究了转移到疏水石英基片上的二棕榈酰磷酯酰胆碱（dppc）与不同浓度聚合物单体分子甲基丙烯酸甲酯（MMA）的混合物所形成的单层LB膜及其缺陷的微结构,研究了沉积压对缺陷的影响。当MMA的摩尔比为33%（即MMA∶dppc=1∶2）,沉积压为5.0mN/m时,生成直径约3～4μm的圆形液态凝聚相（LC）畴区,LC畴区主要为dppc与MMA的混合物,同时还分布着一些由聚合的MMA分子（即聚合物PMMA）形成的“小岛”;当沉积压增加至15.0mN/m时,LC畴区中主要为聚合物PMMA的聚集体。当MMA的摩尔比增加至50%后,LC畴区中聚合物PMMA含量增加。畴区产生的主要原因是由于不同MMA含量和沉积压使dppc和MMA及其聚合物PMMA产生不同程度的相分离所致。MMA/dppc混合LB膜中这种圆形的畴区缺陷可以诱导形成圆形的一水草酸钙晶体沉积图形。

关键词： LB膜缺陷 AFM dppc MMA

不同固醇与dppc二元体系的液态有序相(英文)

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物理化学学报 2008年第7期24卷 1149-1154页

作者：高文颖陈琳吴富根尉志武清华大学化学系生命有机磷化学与化学生物学教育部重点实验室北京100084

应用同步辐射X射线衍射和差示扫描量热法研究了由不同结构的固醇(胆固醇、脱氢胆固醇、豆固醇、谷固醇、麦角固醇以及固醇核)和二棕榈酰磷脂酰胆碱(dppc)二元体系形成的液态有序相.研究表明,胆固醇比植物固醇(豆固醇和谷固醇)和真菌固醇... 详细信息

应用同步辐射X射线衍射和差示扫描量热法研究了由不同结构的固醇(胆固醇、脱氢胆固醇、豆固醇、谷固醇、麦角固醇以及固醇核)和二棕榈酰磷脂酰胆碱(dppc)二元体系形成的液态有序相.研究表明,胆固醇比植物固醇(豆固醇和谷固醇)和真菌固醇(麦角固醇)能更有效地与dppc形成液态有序相(Lo);有胆固醇或者脱氢胆固醇参与的液态有序相能够在较宽的温度范围内保持稳定,而由植物固醇和真菌固醇参与的液态有序相对温度有较强的依赖性,在dppc主相变温度附近有明显的热致相变过程,因此这一液态有序相应该进一步区分为Loβ和Loα相.研究结果有助于阐明固醇尾链在液态有序相以及脂筏中的作用,也有助于理解在进化过程中动物细胞膜为何选择胆固醇作为主要固醇.

关键词：固醇 dppc 脂筏 X射线衍射量热技术

Morphology observation of dipalmitoyl phosphatidyl choline (dppc) monolayer on water surface by dropping method

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Journal of Biophysical Chemistry 2013年第4期4卷 115-121页

作者： Daisuke Yoshida Takashi Yokoyama Takatsugu Shimoaki Takashi Tomita Tadayoshi Yoshida Yasushi Yamamoto Keijiro Taga Ayumi Sumino Takehisa Dewa Mamoru Nango Masato Yamamoto Zameer Sheravani Department of Chemistry School of Arts and Sciences Showa University Fujiyoshida Japan Department of Frontier Materials Nagoya Institute of Technology Nagoya Japan Department of Life Science and Material Engineering Nagoya Institute of Technology Nagoya Japan Tohoku Foods Corporation Limited Sendai Japan

Preparation of dppc lipid monolayer in water trough has been done by dropping method and compared with compression method. Monolayer was studied by surface pressure isotherm, fluorescence microscopy, Brewster angle microscopy, and infrared external reflection spectroscopy. Results of these measurements showed that dropping method gave better results compared to compression method. In dropping method, transition from liquid expanded state to liquid condensed is gradual compared to sharp one in compressed method. During monolayer formation, adjustment and interaction between hydrophilic part of lipid and water and among hydrophobic part of lipid molecule are slow, stable, and more natural as worked out from surface area versus pressure isotherm. At a given molecular area, surface pressure is less compared to compression method thus monolayer is in more fluidic state in dropping method than compression method. The observation was supported by all techniques described above.

关键词： dppc Monolayer Dropping Method Surface Tension Fluorescence Microscopy Brewster Angle Microscopy

用NMR方法研究稀土离子对dppc脂质体构象的影响

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科学通报 1993年第12期38卷 1094-1097页

作者：赵大庆高新风裴奉奎倪嘉缵黄芬中国科学院长春应用化学研究所长春130022 中国科学院生物物理研究所北京100080

随着稀土元素在工农业中的广泛应用,稀土进入机体内的作用机理是人们日益关心的问题.而稀土对生物体的作用,首先是通过生物膜.因此研究稀土与生物膜的作用是阐明其生理过程的重要环节.生物膜的结构比较复杂。

关键词： NMR 稀土离子 dppc 脂质体构象

Interactions between Phospholipid Monolayers (dppc and DMPC) and Anesthetic Isoflurane Observed by Quartz Crystal Oscillator

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Journal of Biophysical Chemistry 2015年第2期6卷 42-53页

作者： Yasushi Yamamoto Takashi Yokoyama Daisuke Yoshida Hiroya Mori Karina Sekiguchi Takatsugu Shimoaki Akihiro Yoshino Keijiro Taga Zameer Shervani Masato Yamamoto Department of Materials Science and Engineering Nagoya Institute of Technology Nagoya Japan Tohoku Foods Corporation Limited Sendai Japan Department of Chemistry Graduate School of Science Tohoku University Sendai Japan College of Arts and Sciences Showa University Fujiyoshida Japan

The interactions of phospholipid monolayers (dipalmitoyl phosphatidyl choline;dppc and dimyristoyl phosphatidyl choline;DMPC) with volatile anesthetic isoflurane were investigated using quartz crystal microbalance (QCM) and quartz crystal impedance (QCI) methods. The quartz crystal oscillator was attached horizontally on the surface of dppc and DMPC monolayer formed on the water surface. Physisorption of isoflurane hydrate at the dppc monolayer surface was monitored in terms of frequency and resistance change of quartz crystal on addition of anesthetics isoflurane. Both frequency and resistance change showed the elastic nature of dppc monolayer. Measurement of DMPC monolayer-isoflurane hydrate revealed the expandable nature of DMPC monolayer. Variation of frequency and impedance of dppc and DMPC monolayer on addition of isoflurane which proved a two-step change has occurred at monolayer surface at isoflurane concentration of ≤8 mM that has been attributed to isoflurane aggregation at monolayer/water interface. Isoflurane hydrates formed in the process have capability to affect the interfacial properties of monolayer such as existence of structured water.

关键词： Physisorption dppc Monolayer DMPC Monolayer Quartz Crystal Oscillator Anesthetic Isoflurane-Monolayer Interaction

亚相pH对气水界面上VE/dppc单分子膜的影响

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物理化学学报 1997年第5期13卷 389-394页

作者：莫凤奎朱治方沈阳药科大学基础部沈阳110015

通过表面压-分子面积等温线（π－A线）的测定，考察了亚相pH对气水界面上的维生素E（VE）／二棕榈酰基磷脂酰胆碱（dppc）单分子膜的影响。亚相pH降低不改变dppc单分子膜的崩裂压，但使VE审分子膜的崩裂任明显增大；不改变VE单分子膜... 详细信息

通过表面压-分子面积等温线（π－A线）的测定，考察了亚相pH对气水界面上的维生素E（VE）／二棕榈酰基磷脂酰胆碱（dppc）单分子膜的影响。亚相pH降低不改变dppc单分子膜的崩裂压，但使VE审分子膜的崩裂任明显增大；不改变VE单分子膜的平均分子面积，但使dppc单分子膜凝缩．低表面压下，VE对dppc单分子膜的膨胀作用在纯水上很小，在pH为1的亚相上则很明显．这提示在低pH的亚相上，VE／dppc单分子股中的极性头基间的相互作用对膜性质有着重要的影响．

关键词：维生素E dppc 单分子膜亚相pH 磷脂