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Metal nanoparticles for cancer therapy:Precision targeting of dna damage

Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen Chunyan Fang Fan Xia Qiyue Wang Fangyuan Li Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic ***,dna damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical ***,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical *** nanoparticles present promising avenues for enhancing each critical aspect of dna damage-based cancer *** customizable physicochemical properties enable the development of targeted and personalized treatment *** this review,we delve into the design principles and optimization strategies of metal *** shed light on the limitations of dna damage-based therapy while highlighting the diverse strategies made possible by metal *** encompass targeted drug delivery,inhibition of dna repair mechanisms,induction of cell death,and the cascading immune ***,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle ***,we present insights into the challenges and future directions of metal nanoparticles in advancing dna damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： dna damage Metal nanoparticles Nucleus-targeting dna repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

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Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1329-1340页

作者： Airong Li Chenglin Liang Lihua Xu Yiyang Wang Wei Liu Kaixiang Zhang Junjie Liu Jinjin Shi Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases School of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive ***,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential dna repair of tumor *** by the crucial function of iron ions in 5-ALA transformation and dna repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO ***@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of ***,the activity of dna repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated dna damage in tumor *** findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA.

关键词： 5-Aminolevulinic acid Biotransformation interference Iron ion regulation dna repair inhibition ALKBH2 Membrane fusion liposomes Photodynamic therapy Drug delivery

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