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Construction of Polymeric dna network and Application for Cell Manipulation

Chinese Journal of Chemistry 2023年第15期41卷 1875-1887页

作者： Lele Chang Rui Zhang Jing Wang Chi Yao Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300350China

Comprehensive Summary Deoxyribonucleic acid(dna)is a biomacromolecule,as well as a polymeric material,whose sequences with different manipulative structures enable them to implement a series of functions,such as reorganization,target,and catalysis.Compared to existing traditional materials incapable of multifunctional integration,the polymeric dna network is a form of material that can achieve functional integration while maintaining specific dna properties.Furthermore,precise target enabled by dna network is one of the most essential components of cellular manipulation.Hence,the dna network is indispensable and irreplaceable to cell manipulation that it is a versatile tool for the understanding of basic laws of living life and treatments of diseases,such as cell isolation,cell delivery,and cell interference.Herein,the construction of polymeric dna network is briefly introduced from the aspects of assembly modules,construction methods,and properties.

关键词： dna network dna nanotechnology Cell manipulation Cell isolation and interference

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A likeness ELISA Based on Aptamer Recognition and Enzyme-free dna Isothermal Amplification for Profiling Cancer Cell

A likeness ELISA Based on Aptamer Recognition and Enzyme-fre...

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第十一届全国化学生物学学术会议

作者： Fengming Chen Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan University

Enzyme-linked immunosorbent assay（ELISA） is a traditional and effective method for the detection of antigens in clinic samples,which utilizes an enzyme to catalyze the conversion of a substrate into a colored or highly fluorescent product for quantification.[1] However,it requires complex operations and expensive antibodies,which tremendously limits its applications.Herein,we developed a simple ELISA-based dna network involved with different aptamers instead of antibodies to capture targeted cancer cell with high specific affinity.Cancer cells profiling can be realized via the amplification of dna aptamer-based entropy-driven reaction on living cell membrane.[2] This study provides a new strategy for aptamer applications in bioanalysis and biomedical engineering.

关键词： dna network Amplification ELISA Cell profiling

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