检索结果-南通市图书馆

Applications of dna nanotechnology in Synthesis and Assembly of Inorganic Nanomaterials

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2016年第3期34卷 291-298页

作者： Yurou Ma Xiangdong Yang Yurong Wei Quan Yuan Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering Hubei University Wuhan Hubei 430062 China

In addition to its inherited genetic function, dna is one of the smartest and most flexible self-assembling na- nomaterials with programmable and predictable features, for which, more and more scientists combine dna with nanomaterials and put them into designing, synthesizing and assembling. In this review, four modes of action of dna molecules are introduced in a figurative and intuitive way, based on the four different roles it plays in synthe- sis and assembly of nanomaterials：（a） smart linkers to guide nanoparticle assembly, （b） 2D or 3D scaffold with well-designed binding sites, （c） nucleation sites to directly facilitate Au/Pd/Ag/Cu nanowires, nanoparticles, nano- arrays and （d） serving as capping agents to prevent crystal growth, and control size and morphology. To be sure, this state-of-the-art combination of functional dna molecules and inorganic nanomaterials greatly encouraged step towards the development of analytical science, life science, environmental science, and other promising field they can address. dna-guided nanofabrication will eventually exceed expectations far beyond our scope in the near fu- ture.

关键词： inorganic nanomaterial dna nanotechnology dna origami assembly

Recent advancements in dna nanotechnology-enabled extracellular vesicles detection and diagnosis:A mini review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第6期34卷 101-110页

作者： Rongrong Huang Lei He Lian Jin Zhiyang Li Nongyue He Wenjun Miao School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 211816China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 211189China

Extracellular vesicles(EVs)are cell-derived nanosized vesicles widely recognized for their critical roles in various pathophysiological *** analysis of EVs is currently being considered an emerging tool for diseases ***,the small size and heterogeneity of EVs has staggered the EVs research for diseases *** nanotechnology enables self-assembly of versatile dna nanostructures and has shown enormous potential in assisting EVs *** this review,we briefly introduce the recent advances in dna nanotechnology approaches for EVs *** approaches were categorized based on the dimension of dna *** provide critical evaluation of these approaches,and summarize the pros and cons of specific ***,we discuss the challenges and future perspectives in this field.

关键词： dna nanotechnology Extracellular vesicles Lipid biopsy dna-enabled biosensors Rolling circle amplification

Special Issue of ＂dna nanotechnology＂

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2016年第3期34卷 251-251页

作者： Chunai Fan Hao Pei CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai China Department of Chemistry School of Chemistry and Molecular Engineering East China Normal University Shanghai China

The term ＂dna nanotechnology＂ describes the de- sign and fabrication of self-assembled nucleic acid nanostructures for various applications. Since Nadrian Seeman pioneered this area in the early 1980s, there has been tremendous interest in creating dna nanostruc- tures with controlled geometry and topology by utilizing the unique precision in base-pairing of nucleic acids. Along with the rapid emergence and merging of bio- technology and nanotechnology in recent years, various ＂art-like＂ dna nanostructures in one, two, or three di- mensions have been designed, constructed and exploited for a wide range of applications, including nanorobots, optical and electronic devices, diagnosis and therapy.

关键词： dna nanotechnology ELECTRONIC apparatus & appliances BASE pairs

Nucleic acids analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第2期64卷 171-203页

作者： Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Cancer Metastasis Alert and Prevention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China CAS Key Laboratory of Standardization and Measurement for nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and BiodetectionSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Faculty of Materials Science and Chemistry Engineering Research Center of Nano-Geomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China College of Chemistry and Molecular Engineering Biomedical Pioneering Innovation Center(BIOPIC)Beijing Advanced Innovation Center for Genomics(ICG)Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced

Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic *** the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological *** this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided.

关键词： nucleic acids analysis signal amplification dna nanotechnology aptamer biosensing

Framework nucleic acid-based confined enzyme cascade for efficient synergistic cancer therapy in vivo

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第4期64卷 660-665页

作者： Gezhi Kong Meng Zhang Mengyi Xiong Mei Chen Chan Yang Yan Zhao Yue Yang Zilong Zhao Zhi-Ling Song Liang Gong Guoliang Ke Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollaborative Innovation Center for Chemistry and Molecular MedicineHunan UniversityChangsha 410082China College of Materials Science and Engineering Hunan UniversityChangsha 410082China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science Ministry of Education/Shandong Key Laboratory of Biochemical Analysis/College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Sciences and ChemistryHunan University of TechnologyZhuzhou 412007China

Artificial enzyme cascade systems with confinement effect are highly important in synthetic biology and ***,a framework nucleic acid-based confined enzyme cascade(FNA-CEC)for synergistic cancer therapy in vivo was *** FNA-CEC consisted of glucose oxidase and horseradish peroxidase precisely assembled on an addressable dna tetrahedron scaffold within few *** oxidase(GOx)can trigger efficient glucose depletion for tumor starvation therapy,and increase the local concentration of H_(2)O_(2) in situ for enhanced downstream horseradish peroxidase(HRP)-activated prodrug *** to the spatial-confinement on dna tetrahedron scaffold,the efficiency of intermediate metabolites transportation between the enzyme cascades was ***,FNA-CEC was applied for efficient synergistic cancer therapy in vitro and in *** a simple and efficient approach,the FNA-CEC is expected to expand the toolbox of technologies in synthetic biology and biomedicine.

关键词： dna nanotechnology dna nanostructures drug delivery enzyme cascade cancer therapy

Supramolecular Polymerization of dna Double-Crossover-Like Motifs in Various Dimensions

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2023年第10期41卷 1501-1507页

作者： Cui-Zheng Zhang Da-Ke Mao Victoria E.Paluzzi Cheng-De Mao Department of Chemistry Purdue UniversityWest LafayetteIN47906USA

Double-crossover-like(DXL)molecules are a series of dna motifs containing two strands with identical or different *** homo-or hetero-dimers can further polymerize into bulk structures through specific hydrogen bonding between sticky *** molecules have high designability,predictivity and sequence robustness;and their supramolecular polymerization products would easily achieve controllable *** addition,among all available dna nanomotifs,DXL molecules are small in size so that the cost of DXL-based nanostructures is *** properties together make DXL-based nanostructures good candidates for patterning,templating,information and matter storage,***,we will discuss DXL motifs in terms of the detailed molecular design,and their supramolecular polymerization in various dimensions,and related applications.

关键词： dna nanotechnology Palindromic sequence Helical twisting Supramolecular polymerization Controllable morphology

Versatile multiplexed super-resolution imaging of nanostructures by Quencher-Exchange-PAINT

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第12期11卷 6141-6154页

作者： Tobias Lutz Alexander H.Clowsley Ruisheng Lin Stefano Pagliara Lorenzo Di Michele Christian Soeller Living Systems Institute & Biomedical Physics University of ExeterExeter EX44QDUK Cavendish Laboratory University of CambridgeCambridge CB30HEUK

The optical super-resolution technique dna-PAINT (Point Accumulation Imaging in Nanoscale Topography) provides a flexible way to achieve imaging of nanoscale structures at ∼10-nanometer resolution. In dna-PAINT, fluorescently labeled dna “imager” strands bind transiently and with high specificity to complementary target “docking” strands anchored to the structure of interest. The localization of single binding events enables the assembly of a super-resolution image, and this approach effectively circumvents photobleaching. The solution exchange of imager strands is the basis of Exchange-PAINT, which enables multiplexed imaging that avoids chromatic aberrations. Fluid exchange during imaging typically requires specialized chambers or washes, which can disturb the sample. Additionally, diffusional washout of imager strands is slow in thick samples such as biological tissue slices. Here, we introduce Quencher-Exchange-PAINT—a new approach to Exchange-PAINT in regular open-top imaging chambers—which overcomes the comparatively slow imager strand switching via diffusional imager washout. Quencher-Exchange-PAINT uses “quencher” strands, i.e., oligonucleotides that prevent the imager from binding to the targets, to rapidly reduce unwanted single-stranded imager concentrations to negligible levels, decoupled from the absolute imager concentration. The quencher strands contain an effective dye quencher that reduces the fluorescence of quenched imager strands to negligible levels. We characterized Quencher-Exchange-PAINT when applied to synthetic, cellular, and thick tissue samples. Quencher-Exchange-PAINT opens the way for efficient multiplexed imaging of complex nanostructures, e.g., in thick tissues, without the need for washing steps.

关键词： super-resolution microscopy fluorescence imaging dna nanotechnology dna-PAINT fluorescence quencher

A smart dna nanodevice for ATP-activatable bioimaging and photodynamic therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2020年第10期63卷 1490-1497页

作者： Bei Liu Rui Ma Jian Zhao Yuliang Zhao Lele Li School of Science Minzu University of ChinaBeijing 100081China CAS Key Laboratoty for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China GBA Research Innovation Institute for nanotechnology Guangdong 510700China

Rational design of activatable photosensitizers for controlled generation of singlet oxygen remains a challenge for precise photodynamic therapy(PDT).Herein,we present an aptamer-based nanodevice for adenosine 5′-triphosphate(ATP)-activatable bioimaging and *** nanodevice is constructed by modifying ATP-responsive duplex dna units and polyethylene glycol on the surface of a gold nanoparticle(AuNP)through the thiolate-Au *** dna units were designed by the hybridization of the ATP aptamer strand with a methylene blue(MB)-modified complementary dna(cdna).The close proximity of MB to the surface of AuNP results in the low photodynamic activity of MB(OFF state).Once internalized into cancer cells,the ATP-binding induced conformation switch of aptamer strand leads to the release of the MB-bearing dna strand from AuNPs,resulting in the activatable generation of singlet oxygen under light irradiation(ON state).We demonstrate that the dna nanodevice represents a promising platform for ATP-responsive bioimaging and specific PDT in vitro and in *** work highlights a potential way for specific tumor diagnosis and therapy.

关键词： dna nanotechnology ATP-activatable photodynamic therapy bioimaging

Engineering dna quadruplexes in dna nanostructures for biosensor construction

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第4期15卷 3504-3513页

作者： Jingxin Liu Li Yan Shiliang He Junqing Hu College of Health Science and Environmental Engineering Shenzhen Technology UniversityShenzhen 518118China Shenzhen Bey Laboratory Shenzhen 518132China

dna quadruplexes are nucleic acid conformations comprised of four *** are prevalent in human genomes and increasing efforts are being directed toward their *** advantage of the programmability of Watson-Crick base-pairing and conjugation methodology of dna with other molecules,dna nanostructures of increasing complexity and diversified geometries have been artificially constructed since *** this review,we investigate the interweaving of natural dna quadruplexes and artificial dna nanostructures in the development of the ever-prosperous field of biosensing,highlighting their specific roles in the construction of biosensor,including recognition probe,signal probe,signal amplifier and support *** implementation in various sensing scenes was *** finally,general conclusion and future perspective are discussed for further developments.

关键词： G-quadruplex i-motif dna nanotechnology biosensor