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A color image encryption algorithm based on hyperchaotic map and dna mutation

Chinese Physics B 2023年第3期32卷 131-142页

作者：高昕瑜孙博曹颖鸿 Santo Banerjee 牟俊 School of Information Science and Engineering Dalian Polytechnic UniversityDalian 116034China Department of Mathematical Sciences Giuseppe Luigi LagrangePolitecnico di TorinoCorso Duca degli Abruzzi 24TorinoItaly

We devise a color image encryption scheme via combining hyperchaotic map,cross-plane operation and gene ***,the hyperchaotic map used in the encryption scheme is analyzed and *** the basis of the dynamics of hyperchaotic map,a color image encryption scheme is *** the end of the encryption process,a dna mutation operation is used to increase the encoding images’randomness and to improve the encryption algorithm’s ***,simulation experiments,performance analysis,and attack tests are performed to prove the effectiveness and security of the designed *** work provides the possibility of applying chaos theory and gene theory in image encryption.

关键词： color image encryption hyperchaotic map cross-plane permutation dna mutation

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Sensitive dna mutation Detection at Physiological Temperature with Endonuclease IV by Inhibiting Its Side Activity

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Chinese Journal of Chemistry 2021年第9期39卷 2477-2482页

作者： Zhen Zhang Longjie Li Qingxu Liu Yuqiang Hu Wenqian Yuan Xianjin Xiao Tongbo Wu School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Institute of Reproductive Health/Center of Reproductive Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Endonuclease IV(Endo IV)has the side activity to cleave the apurinic/apyrimidinic site in the single-stranded dna probe(AP-ssdna),which adversely affects its performance in single-nucleotide variation(SNV)*** this work,we developed a simple strategy to inhibit Endo IV's side activity by introducing an assistant strand into the detection *** assistant strand effectively inhibited the side-activity of Endo IV by conf ini ng the freedom of AP-ssdna through rigid double-stranded dna formati on,and the inhibition efficiency could reach 98%.About 20 times enhancement of the discrimination factor(DF)was obtained compared to the detection system without the assistant *** optimization,a mean DF value was calculated to be 738 for different mutation types,and the sample with 0.005%allele frequency was discriminated from the wild-type *** advantage of using an assists nt stra nd was that the SNV detection could be executed at physiological temperature without precise temperature optimization as in other Endo IV-based SNV detection ***,EGFR T790M mutant in the synthesized and clinical samples was detected by our *** results showed satisfactory sensitivity and accuracy by comparison with Sanger ***,this strategy has the potential to be applied in the field of precision medicine.

关键词： dna mutation Enzymes Side activity Fluorescent probes Biose nsors

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Polymorphism analysis of PARK2 gene mutations in Han Chinese patients with early-onset Parkinson's disease

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Neural Regeneration Research 2010年第20期5卷 1578-1582页

作者： Yuancheng Bao Ting Guan Yuanxun Yu Huaizhou Jiang Changshui Fang Lijuan Chen Department of Neurology First Affiliated Hospital of Anhui Traditional Chinese Medical College Hefei 230031 A nhui Province China Anhui Center for Medical Genetics Hefei 230061 Anhui Province China School of International Education & Exchange Anhui Traditional Chinese Medical College Hefei 230031 Anhui Province China

The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s *** detection of mutations in the PARK2 gene remains *** investigate the role PARK2 gene mutations play in the pathogenesis of Parkinson＇s disease,30 Han Chinese patients with early-onset Parkinson＇s disease and 38 normal controls were studied to determine the sequence changes of 1,4,6 and 7 exon *** the 30 patients with Parkinson＇s disease,a heterozygous intron mutation（nt 119,G→G/A）in exon 1 was detected in one case;a homozygous intron mutation（nt 526500,T→C）between intron 3 and exon 4 in fourteen cases was found;a heterozygous intron mutation（nt 526607,G→G/A）between intron 3 and exon 4 was observed in eight cases;an exon 6missense mutation（nt 754317,C→C/T;codon 193,CGG→CGG/TGG;aa 193,Arg→Arg/Trp）in three cases was seen;and an exon 7 missense mutation（nt 941943,C→A/C;codon 272,CTC→CTC/ATC;aa 272,Leu→Leu/lle）was found in one *** changes were not found in the normal *** results indicated that the PARK2 exons 6 and 7 mutations are possibly pathogenic mutations,along with the intron 3-exert 4 and exon 1 ***2 gene mutations are possible factors leading to the onset of Parkinson＇s disease.

关键词： Parkinson's disease PARK2 gene dna mutation oxen intron

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Novel ATP7B gene mutations in Chinese Han patients with hepatolenticular degeneration

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Neural Regeneration Research 2010年第12期5卷 933-937页

作者： Yuancheng Bao Lijuan Chen Yuanxun Yu Huaizhou Jiang Ting Guan Changshui Fang Department of Neurology FirstAffiliated Hospital of Anhui Traditional Chinese Medical College Hefei 230031 Anhui Province China Anhui Center for Medical Genetics Hefei 230061 Anhui Province China

BACKGROUND： ATP7B gene exon 8 Arg778Leu and exon 12 Arg952Lys are gene mutation hot spots in Chinese Han patients with hepatolenticular degeneration, or Wilson＇s disease （WD）. However, the gene fragments are too short for detection and the mutation detection rate remains low. OBJECTIVE： To analyze dna sequences of ATP7B gene exon 8-exon 9 and exon 10-exon 12 sections. DESIGN, TIME AND SE＇I-rlNG： A concurrent, non-randomized, controlled, genetic polymorphism study was performed at the Anhui Medical Genetics Center, Anhui, China from March to July in 2009. PARTICIPANTS： Fifty patients, who were admitted to the Department of Neurology at the First Affiliated Hospital of Anhui Traditional Chinese Medical College between March and July in 2009, were diagnosed with WD. The WD group comprised 32 males and 18 females, with an average age of （18.8 ± 8.3） years. WD was confirmed by clinical observation, as well as physical, imaging, and biochemical examinations, including testing for serum copper, ceruloplasmin, and copper oxidase. The control group comprised 20 normal subjects, who underwent physical examination at the First Affiliated Hospital of Anhui Traditional Chinese Medical College, and included 13 males and 7 females, with an average age of （27.9 ± 2.4） years. All subjects were Chinese Han population. METHODS： Genomic dna was extracted from 50 WD patients and 20 normal controls. Polymerase chain reaction amplification of ATP7B gene exon 8-exon 9 （about 1 100 bp） and exon 10-exon 12 （about 850 bp） segments was performed. dna exon-intron amplification products from all subjects were processed through direct bidirectional sequencing, and sequencing results were analyzed. MAIN OUTCOME MEASURES： Sequence changes of ATPTB gene exon 8-exon 9 and exon 10-exon 12 segments. RESULTS： In the 50 included WD patients, ATP7B gene intron 8 nt53592A → G with nt53671G→ A homozygous mutation was detected between exon 8-exon 9 in seven cases; exon 8 Arg778Leu mutations with Leu770Leu sy

关键词： hepatolenticular degeneration Wilson's disease gene dna mutation copper metabolism genetics neural regeneration

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